RT @vallisubasri: ✨Check out our study✨We use germline genetic and epigenetic data to identify diagnostic biomarkers, prognostic signatures….

In the future this holistic approach could be used to develop tailored strategies for cancer surveillance in patients with this rare and devastating cancer predisposition syndrome.

@vallisubasri used this to develop a machine learning model which can predict cancer risk in patients with Li Fraumeni Syndrome.

Amazing work by @vallisubasri comprehensively investigating the ways in which germline genetic variants and epimutations effect cancer risk in patients with Li-Fraumeni syndrome, using whole genome sequencing and methylation data from 396 LFS patients.

RT @natedandy_PhD: Happy to share our preview on the spatial organization of microbiota in cancer published in @ImmunityCP. Original pap….

Our study is out today in @NatureComms ! We analyzed cancer genomes from patients with Li-Fraumeni syndrome and found early copy number gain of the mutant allele of TP53 to be a characteristic feature of these tumours.

Amazing to watch this study grow over the past 7+ years. Congrats to the entire KiCS program!.

RT @NaheedD: Who else thinks that instead of wasting millions of tax dollars on private, for-profit agencies to provide hospitals with temp….

Congrats @cd_steele and @NischalanP ! Glad to have made a small contribution to this foundational work!.

RT @uoftmdphd: Congratulations again to all of our 2022 MD/PhD Graduates: @AlainnaJJ, @nick_light, @skzahr, @TinaMarvasti, @ben_ouyang, @ay….

Congrats @andygxzeng! Amazing study characterizing and stratifying the stem cell hierarchy in >1000 AML patients into 4 major classes, with distinct biology, clinical outcomes and drug sensitivity @uoftmdphd.

RT @EricTopol: This week @TheLancet's cover

Incredibly thankful for the opportunity to train in Internal Medicine at UofT! Grateful for my 8 years @uoftmdphd and over the moon to be continuing my training here. I cannot thank enough all the amazing people who have supported me through this process. Excited to get to work!

It's now available on amazon:

My Dad and his friend just released their new book on life in Paris in the 70s, and its already got great reviews! "Both authors skillfully build on each other’s recollections to bring a vanished world to vibrant life" @KirkusReviews . All royalties go to the @RedCrossUkraine🇺🇦

RT @SerenaNikZainal: Yay! Our review is paper out!!🤓🥳🕺💃🕺💃.Hope it is useful for the community!. #MutationalSignatures : Emerging concepts,….

Congrats @nathanielDA_PhD ! A massive advance in our understanding of leiomyosarcoma, pointing to a new therapeutic option for these patients.

RT @LFSAssociation: Today is International Li-Fraumeni Syndrome Awareness Day, co-sponsored by the @theNCI‘s Division of Cancer Epidemiolog….

Incredible. Uncanny. Unnerving. Also, kind of loveable.

I have a joke about sequence variants but I always make a typo in the punchlinee.