Mel Symeonides
@msymeonides
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Assistant Prof at the University of Vermont, interested in HIV latency, syncytia, placenta etc. Opinions = my own. @msymeonides.bsky.social
Burlington, VT
Joined November 2008
VERMONT GREEN ARE DIVISION CHAMPS! ๐ THE UNBEATEN BOYS IN GREEN CLAIM THE FIRST TITLE IN CLUB HISTORY. VERMONT, THIS ONEโS FOR YOU!ย MERCI LES VERTS! ๐
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This feels desperate but does anyone happen to have a full-length sequence for the HIV-R7/E-/GFP vector, the one that's in J-Lat cells?
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WOW this looks amazing
Intestinal Immuno-Organoids (IIOs): Striking differences between immune cells in the blood or resident in the intestine which are maintained in vitro! Implications for T-Cell Bispecific and other therapy? @Nature @EricTopol @Roche @IHB_Research
https://t.co/x6YWSjl8yp
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And major props to @embojournal for publishing it!
Our work on ERM proteins in macrophage migration and cortex mechanics is out in the EMBO Journal ๐ https://t.co/W9QeqX2pN2 Great review process by @ReviewCommons ๐ And here is a thread on this story: https://t.co/bckCHvUd52
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Great work! Now imagine a scenario where this was the first time anyone had looked at the role of ERMs in migration in any cell type... Negative data, probably not worth publishing, right? Wrong! Publish "negative data"!
We are excited to announce that our latest paper on macrophage migration and the cortex of these amazing cells is now available on @bioRxiv. https://t.co/v62x8yVrxs Thread 1/ ๐
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Found deceased mole in our crawlspace. The smell was unbelievable. It tried to dig a tunnel through the insulation to get out. A MOLE.
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Happy to share our lab's first preprint! We found that ER tubules hitchhike on Rab6-marked vesicles. Proud of grad student @a_m_langley, lab tech @AbelingSarah and undergrad Erinn Wagner @uvmcmb @UVMLarnerMed
Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases https://t.co/6i4C93vZem
#biorxiv_cellbio
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I'm going to start a new hashtag to show cases where universities or journals have been notified of severe (image) concerns years ago, but have not taken any action. I will name and shame, because it's frustrating and maddening. #IntegrityInertia
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@SolidEvidence Key comment in the paper: "To date, we have not encountered any cases with persistent SARS-CoV-2 infection that has not responded to tailored antiviral treatment after recognition of the condition." Chronic infections can be cured & should be a public health priority.
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Not sure about the biological relevance of this finding given that CD4 T cells basically seem to not do this... But very interesting and a very well thought-out series of controls! One more reason to be wary of Jurkat and THP-1 cells...
Retroviral genomes are translated after entry, challenging the notion that retroviruses require reverse transcription to produce viral proteins, which has significant implications for basic retrovirology, immune responses and gene therapy applications https://t.co/E6Y4aHVGks
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Retroviral genomes are translated after entry, challenging the notion that retroviruses require reverse transcription to produce viral proteins, which has significant implications for basic retrovirology, immune responses and gene therapy applications https://t.co/E6Y4aHVGks
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Are you a cell biologist interested in nanoscale fluorescence imaging? Check out our new review @TrendsCellBio
https://t.co/XTXSj4IVBf Thanks and kudos to all authors: @ElisaDEste @AndImaging @RLincolnChemist @FelipeOpaz_o
#dye #imaging #nanoscopy #superresolution
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This is nothing like the BA.1 or Delta waves. Both of those lineages were the dominant lineage in the state within 2-3 weeks of arriving with immediate spikes in wastewater numbers. 3/
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If you're still on here trying to have reasoned discussions and exchange meaningful information, yikes.
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Do you think you've had long-term GI problems since having Covid? We are performing a study examining the characteristics of viruses, specifically persistent SARS-CoV-2 infections, in stool samples. 1/3
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There's a garbage paper going around claiming detection of vaccine spike in the circulation 6 months after vaccination... it's nonsense and is by the same guy who claimed (and is selling a book saying) that SARS2 is a bacteriophage. Enough said.
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