John Salogiannis
@JSalogiannis
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Assistant Professor, Dept. of Mol. Physiology and Biophysics @UVMLarnerMed Microtubule-based transport
Burlington, VT
Joined August 2020
AcbdA mutants disrupt the localization and movement of peroxisomes, but Rab5-marked early endosomes move normally
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Preprint from our lab is out! We identified a new regulator of peroxisome hitchhiking on early endosomes - acyl-coA binding protein AcbdA - that localizes to peroxisomes and regulates membrane contact site formation.
biorxiv.org
Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an...
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Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes https://t.co/tjqQlsSCxw
#biorxiv_cellbio
biorxiv.org
Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an...
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Happy to share our lab's first preprint! We found that ER tubules hitchhike on Rab6-marked vesicles. Proud of grad student @a_m_langley, lab tech @AbelingSarah and undergrad Erinn Wagner @uvmcmb @UVMLarnerMed
Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases https://t.co/6i4C93vZem
#biorxiv_cellbio
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Had a great time speaking in the Cytoskeleton and Intracellular Transport session at #fungal24 in Asilomar with a great lineup of speakers. Thanks to Xin Xiang and Rosa Mourino-Perez for the invitation!
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Reminder that registrations and abstract submissions for the 2024 Plant & Microbial Cytoskeleton GRS and GRC are open! GRS co-chaired by me and @LiviaSongster, GRC by @SophieMartinLab and Alex Paredez. Fantastic speaker line-up!🌱 🦠 🍄 https://t.co/j0F7qtkKIV
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Please consider applying, I love it here! The environment within my department is extremely supportive and collaborative.
The MPBP Department in @UVMLarnerMed is collaborating with @UVMcancercenter to recruit a new colleague. Please RT. https://t.co/aBQMJ5iAaz
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Super proud of my graduate student Ally Morrissey @amorr_science for winning the @UVMLarnerMed Graduate Research Showcase! Congratulations.
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Just wrapped our regional version of the Motile and Contractile Systems here @uvmvermont featuring 17 labs across six institutions (McGill, Dartmouth, UVM, RPI, TJU, and UMich). Thank you to the Keynote speaker Puck Ohi @R_Ohi_Lab and thanks to @jstumpffVT for co-organizing!
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1/ We’re excited to share our work on HIV-1 trafficking by dynein! Led by the amazing @badieyan in the lab with wonderful collaborations with @EdcampbellLab, @GiessenLab, Aiken Lab, Böcking Lab, and @morgan_desantis. TL;DR HIV-1 hijacks the dynein motor protein for motility 🧵
HIV-1 binds dynein directly to hijack microtubule transport machinery https://t.co/RzYZw7ePXS
#bioRxiv
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My university is running a faculty search for a microbiome/cancer research. DM if you want to know more abt the position or beautiful Green Mountain State. Please RT. @Ashu_Mangalam @Lauriemcox @LupusMicrobiome @Pdorrestein1 @KnightLabNews @LabAllaband
nature.com
Assistant/Associate Professor Position in Microbiome and Cancer Research (#F2691PO) The Department of Microbiology and Molecular Genetics (MMG) a...
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Excited to share my first, first-author preprint on bioRxiv! Check out how we investigated the mechanism and function of specialized peroxisome (Woronin body) motility in Aspergillus 😁
Woronin bodies move dynamically and bidirectionally by hitchhiking on early endosomes in Aspergillus nidulans https://t.co/AoSPljefmb
#biorxiv_cellbio
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Our paper using evolution to find an antiviral role and viral antagonism of NINL is now published in eLife! https://t.co/XuBvfF4Vo7 Fantastic collaboration with @SamReckPeterson, hopefully the first of many! Congrats to everyone, especially @dalexstevens and Chris Beierschmitt!
elifesciences.org
Evolution-guided functional analyses identify an activating adaptor of the dynein intracellular transportation machinery, NINL, as a novel component of the antiviral immune response and reveal a...
New preprint from my lab and @SamReckPeterson lab describing our evolution-guided discovery of a new host-virus conflict involving the dynein activating adaptor NINL! https://t.co/gw4VYA2vmx Congrats to everyone, especially first authors @dalexstevens and Chris Beierschmitt! 1/
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Excited to share this wonderful collaborative story on how Lis1 helps relieve dynein auto-inhibition. Loved working with @aleschziner and the extraordinary women that are @JaniceReimer3, @Aga_Kendrick and @SamReckPeterson
biorxiv.org
Cytoplasmic dynein-1 transports many intracellular cargos towards microtubule minus ends. Dynein is autoinhibited and undergoes conformational changes to form an active complex, consisting of one or...
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Please consider applying! As a new faculty in the Dept of Mol Phys and Biophysics @UVMLarnerMed, I absolutely love the scientific environment here. Extremely supportive. It also doesn’t hurt that VT is such an awesome place to live!
Our department within @UVMLarnerMed is partnering with the @UVMcancercenter for a newly launched faculty search. We'd love to have you join us in beautiful Vermont! Please RT. https://t.co/9J8oLRmtTR
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Our study of pathogenic mutations in KIF22, led by @alexfthompson, is out in @eLife. This was a great collab with the @SNP_Dogg, Lian, Klee, and Babovic-Vuksanovic labs and includes data from UVM undergrads Sarah Stevens and Noah Arons @uvmcmb @UVMLarnerMed @UVMcancercenter
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Thanks @dalexstevens for inviting me to be a faculty mentor at the GRS motors. Great discussion with grad students and postdocs!
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Excited to share the preprint of the work I have spent many sleepless nights on. 1/6
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Talk opportunities available for graduate students or post docs at the upcoming Cytoskeletal Motors GRS. I’m looking for individuals that work on cytoskeletal motors in the context of disease but all are welcome! Retweet this far and wide! Sign up at
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