Manish Mishra
@mmishrabio
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Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans https://t.co/T1uaMoHW4k
journals.physiology.org
Adult males and females have markedly different body composition, and energy expenditure and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the...
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Our paper showing activation of Parkin saves the heart from remodeling after a heart attack is published! Proteomics was extensively used to show the mechanism of action!!!
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Delighted to share our recent review out in Nature Reviews Endocrinology today. Sex matters if you are interested in muscle metabolism in exercise! Great collaborations with @kirstin_mac4 @Ellefs1s @NicoPillon and Daniel Hammarström https://t.co/A2e4HgT31M
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Our work is now online @NatureComms! Led by @biancamarcella_ we show that GSK3 inhibition, alone or combined with exercise, can provide benefits to muscle and metabolic health in mdx mice!
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Newest insight in exercise effects on muscle insulin action in men with normal and decreased insulin sensitivity.
New! Online now: Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action https://t.co/eKJN94ht3N
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Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice https://t.co/TFHw8Tffcx
advanced.onlinelibrary.wiley.com
In aging UCP1-/- mice, brown fat function declines, while beige fat-specific creatine biosynthesis is increased to sustain its mitochondrial function. Besides, the enhanced secreted creatine from...
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Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage https://t.co/S4eBdnCT8Y
nature.com
Scientific Reports - Acute resistance exercise and training reduce desmin phosphorylation at serine 31 in human skeletal muscle, making the protein less prone to cleavage
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The immune landscape of murine skeletal muscle regeneration and aging https://t.co/OzUWGqgYuK
cell.com
Sousa et al. characterized, with time and single-cell resolution, the immune environment of the regenerating skeletal muscle, revealing a profound remodeling of myeloid and lymphoid compartments in...
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The use and misuse of ‘biological aging’ in health research "Biological aging clocks are flawed concepts in understanding disease..." @NatureMedicine
https://t.co/YlhsuHwHyZ Discussion of open acces manuscript: 🔗 https://t.co/WFrwT6WKdk]
nature.com
Nature Medicine - Biological aging clocks are flawed concepts in understanding disease.
Accurate aging clocks based on accumulating stochastic variation @schumacherbj @Meyer_DH
https://t.co/UIkHB50DMK
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New publication on AF in aging and frailty: ACE inhibitors are protective. @LibinInstitute @UCalgaryMed Chronic angiotensin converting enzyme inhibition attenuates frailty and protects against atrial fibrillation in aging mice - Heart Rhythm
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Transient caspase-mediated activation of caspase-activated DNase causes DNA damage required for phagocytic macrophage differentiation
cell.com
Mechanisms of versatile and self-renewing phagocytic macrophage differentiation remain unclear. Maurya et al. show that the PI3K/Akt signaling through the ROS/Ask1/JNK axis regulates the sublethal...
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Our new review in @Cell_Metabolism on the relationship between Metabolism and Frailty is now live! Discusses how maintaining a youthful metabolism in later life can help prevent frailty. Congrats to co-authors including @Alice_E_Kane @mmishrabio
https://t.co/dRU9LkKfFG
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Congratulations to Dr. Kenneth Rockwood on receiving the Health Research Foundation of Innovative Medicines Canada 2023 Medal of Honour at an awards ceremony in Montreal on November 16. Read more here: https://t.co/zMLMxvRbF6
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Dr. Hesham Sadek et al. commented on an article by Dr. Lerchenmüller et al. highlights a subtle, yet important, role of exercise in myocardial renewal in the aging mammalian heart. https://t.co/ieHOocaEVu
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Congratulations to Dr. Laurie J. Morrison (@Rescudoc) – the first Canadian and second woman honoured with the @American_Heart Lifetime Achievement Award in Cardiac Resuscitation Science. Her contributions to resuscitation science transformed emergency medicine worldwide. 👏❤️
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👏Congratulations to the authors of "Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets"(Rouhana, Jacyniak et al.) on winning this month's #APSselect award 🏆in @ajpheartcirc! https://t.co/0S5hk2pOnK
@magiefrancis @akelvinlab @glenpyle
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Online Now: Lactate activates the mitochondrial electron transport chain independently of its metabolism https://t.co/njqiCZzvhg
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The total mass, number, and distribution of immune cells in the human body: ~2 trillion cells collectively weighting ~1.2 kg (40% are lymphocytes, 10% macrophages)
pnas.org
The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells compris...
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HUGE BREAKING - NEW INDIA slams Canada response on diplomats’ departure. MEA said the reduction was necessitated due to Canada’s continued interference in India’s internal affairs 🔥🔥 India accused Justin Trudeau Govt of maintaining a much higher number of diplomats in India.
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