Madhav Mantri
@mantri_madhav
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In this @NatureGenetics commentary, I reflect on an older paper from the Campbell group @sangerinstitute showing how normal skin is full cancer mutations yet stays healthy to highlight the opportunity to revisit this question using new spatial omics tech: https://t.co/eZ6T4WLtKm
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RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance https://t.co/eJL1IaM3VD
#biorxiv_cancer
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CRISPR screens revolutionized genetics; but what if the method itself introduces noise? 🤔 📣We developed RESTRICT-seq, a next-gen screening method to address this📣. #PrecisionGenomics
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Brilliant idea with big impact! Must read🧬 Amazing work!! Congratulations @AlexandrePCheng!!! 👏👏
Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀 See ⬇️ for a primer on the next frontier of genomics https://t.co/kl2KOaKziW
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Our work using cell-free RNA as a minimally invasive bioanalyte to investigate circulating biomarkers and the pathobiology of ME/CFS is out today in @PNASNews! Led by @IwijnDeVlaminck, @DrMaureenHanson, and @CornellMECFS
#cfRNA #MECFS #PNAS
https://t.co/J9R6kEZAIF
pnas.org
People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience heterogeneous and debilitating symptoms that lack suffici...
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Excited to share our urine cell-free RNA (cfRNA) study, now out in @Clin_Chem_ADLM Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications https://t.co/fvKbOUB5LZ
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Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures https://t.co/B02Yzb29Mi
#biorxiv_immuno
biorxiv.org
The human immune system undergoes continuous remodeling from infancy through old age, yet the timing and trajectory of these changes across the lifespan remain poorly defined. To address this, we...
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A study in @Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. https://t.co/1CZ7ZeU2m1
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"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response"
biorxiv.org
Histone H3 Lysine 4 trimethylation (H3K4me3) is widely recognized as a hallmark of actively transcribed gene promoters, yet its precise role in transcriptional regulation remains unresolved[1][1]–[...
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Nonuniversality of inflammaging across human populations https://t.co/qAZcUYtVGq
nature.com
Nature Aging - Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in...
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Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a surprise: an 85% drop in NAD⁺ in mouse muscle leaves epigenetic age unchanged. Muscle structure, function, and mitochondria stay strong: NAD⁺ loss ≠ muscle
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🚨New paper on theories of ageing I discuss the major mechanistic theories of ageing in light of recent findings as well as the fundamental nature of the ageing process. Theoretical work is more important than ever in biology, including in ageing. https://t.co/JG7XLI6QFS
nature.com
Nature Cell Biology - This Review provides an overview of modern mechanistic theories and critically examines two main groups of ageing theories—error and program based—in the context...
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🧠 Zoning out could be beneficial—and may actually help us learn faster. 🥼 New research led by @Lin_Zhong_ion @marius10p & @computingnature
https://t.co/PKMVqnk1Un
janelia.org
Actions that may seem unproductive – like aimlessly wandering around a city or exploring a new mall – could play an important role in how our brains learn, according research from HHMI’s Janelia...
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Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities https://t.co/DpwpyejZLO
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Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3 @SciImmunology
https://t.co/OASonAWL0b
science.org
Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.
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Online now: Myocardium and endocardium of the early mammalian heart tube arise from independent multipotent lineages specified at the primitive streak
cell.com
Sendra et al. use clonal analysis and live imaging in mouse embryos to show that the primitive heart arises from two multipotent mesodermal populations, not a cardiac-specific precursor. Myocardial...
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Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄Read in @Nature - https://t.co/teA2IhCpXi 1/12
nature.com
Nature - A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
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Thrilled to share our latest preprint led by the fantastic student Ziyu @ziyu__lu! We constructed a scATAC-seq atlas profiling > 500 mouse tissues to explore cell population dynamics during mammalian aging and the associated chromatin landscape changes: https://t.co/AiIMf5r1hV
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Delighted to share our new study, led by @annacgeraghty and @LehiAcosta , uncovering the cellular dysregulation underpinning cognitive impairment after CAR T cell therapy and a strategy to rescue this cellular and cognitive dysfunction in mice. 1/ https://t.co/07KHI5egRg
cell.com
CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting oligodendroglial...
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