Matt Madden
@madden_mz
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Resident @Yale_LabMed @VanderbiltMSTP alum
New Haven, CT
Joined November 2018
Very happy that @melissa_m_wolf's paper on how loss of VHL in kidney cancer cells reshapes the tumor immune microenvironment to recruit suppressive macrophages & point to a new immunotherapy target in RCC is out in @jclinicalinvest
@VUMC_Cancer
@VUMC_VCI
https://t.co/Qeut9uyn0Y
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Excited to share our latest publication in @PNAS with @KimrynRathmell where we demonstrate that mutation or inhibition of the tumor suppressor SETD2 promotes the formation of a whole host of chromsosomal aberrations including isochromosomes https://t.co/7a09NI3hE6 🧵
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Congrats to @SugiuraAyaka for this new effort w/ Dawn Newcomb & @LyssiotisLab--don't just think about in vivo vs in vitro, which tissue in vivo is key Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation
biorxiv.org
Amino acid (AA) uptake is essential for T cell metabolism and function, but how tissue sites and inflammation affect CD4+ T cell subset requirements for specific AA remains uncertain. Here we tested...
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1/10 Thrilled to congratulate our incredible team including trainees @XG372669, @lobergMatthew, @mtigue13 on our recent publication in @CellGenomics ( https://t.co/oTrscKZ1QV). We use multi-omics methods to advance our understanding of thyroid cancer.
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So excited to see our paper out in @CellGenomics today!! Thanks to all of our collaborators and co-authors for their help and hard work! And special thanks to @XG372669 for the many hours and late night zoom meetings spent working on this project together!
1/10 Thrilled to congratulate our incredible team including trainees @XG372669, @lobergMatthew, @mtigue13 on our recent publication in @CellGenomics ( https://t.co/oTrscKZ1QV). We use multi-omics methods to advance our understanding of thyroid cancer.
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ELATED to highlight our study now out in @CellReports! This project started with a simple but important question: can we use MHC tetramers to study direct pathway CD8 T cells in transplantation? 1/9 https://t.co/YRupMmgLFL
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New preprint from Nowrin Chowdhury & Dawn Newcomb. Sex specific glutaminolysis and Th17 cells--female T cells use more glutamine! Immunometabolism in sex-based differences in immunity, inflammation, & autoimmunity? @VUMC_VCI
https://t.co/6EVLiLPsp7
biorxiv.org
Females have increased prevalence of many Th17-mediated diseases. While androgen signaling decreases Th17-mediated inflammation, the mechanisms are not fully understood. Th17 cells rely on glutamin...
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Just had a wonderful week on cytology with these three fantastic 4th year Vandy med students: George de Castro, @MargaretAxelrod, and @madden_mz. Thrilled that all three of you are applying for residency in Pathology!!!! photo credit to Joel: @_joel_morales @VUMCPathology
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I am excited to share this preprint of a project working with the incredible @Lab_LaBella @RokasLab and @capra_lab. See the the link below for a short twitter thread! https://t.co/hCVIvjs8lO
Preprint Alert! We @abin_abe @Lab_LaBella @RokasLab @capra_lab asked which evolutionary forces have influenced genomic regions associated w/ human traits? We analyzed >900 GWASs to quantify enrichment for 14 evolutionary measures Paper: https://t.co/9bSHbn6r56 Img: our approach
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Are you a soon-to-be college grad excited by tumor immunology? @philiplabvandy has an open Research Assistant position @VUMC_Cancer @VUMC_VCI @VUMCResearch in #Nashville! #researchjobs #PleaseRT
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Congratulations to @SugiuraAyaka for a great closed PhD defense today! Loads of data and an outstanding presentation. Thanks to @AmyMajor6, @HSerezani, Dawn Newcomb, and Mark Boothby--who ever so often popped up so we could see his eyes on the zoom screen
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I joined @JeffRathmell's lab about 2 years ago for my postdoc. Started investigating metabolism of #Tcells in #lupus and took a small tangent into iron metabolism. We are excited to share the preprint of my first paper here! 🥳 https://t.co/qKXpaLvqF5
biorxiv.org
T cells in systemic lupus erythematosus (SLE) exhibit mitochondrial abnormalities including elevated oxidative stress. Because excess iron can promote these phenotypes, we tested iron regulation of...
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I am so happy to be able to say that our manuscript is now published in @ImmunityCP! With the help of in vivo CRISPR screening in an inflammatory model, we identify MTHFD2 as a potential drug target for anti-inflammatory therapy. 1/7
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A study in Nature of the tumour microenvironment reveals cell-intrinsic partitioning in which glucose uptake is higher in myeloid cells, whereas glutamine is preferentially acquired by cancer cells. https://t.co/HU0EIKtFZI
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More BNST findings coming your way! Huge thanks to my fabulous coauthors @JenniBlackford @FeolaBrandee @MegBenningfield Marisa Silveri and Danny Winder https://t.co/UAhmpEjQat
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Proud to share our latest paper showing the prevalence and impact of a neuroanatomic variant in schizophrenia for the first time. Thanks to the guidance and mentorship from @maureenmchugo1 @VandyAtVandy @JenniBlackford @WoodwardLab @StephanHeckers
https://t.co/Pvz5fNjzRI
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First tweet! Excited to announce my lab opened at Johns Hopkins in Sept — looking forward to studying antigen-specific T and B cells in mouse models of transplantation and in humans! @JHUPath @HopkinsMedicine
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GREAT TALK! @BReinfeld MD PHD @VanderbiltU eval glucose in #RCC / found glucose +/- VHL/asked which cells consume glucose? CD45+ non T cells (Macs) eat more glucose than MC38, CT26 & RENCA tu (DNP)/my opinion: All are immunogenic Tu? What about 4T1? #Bridge2019 @FondMelanoma
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