We are hiring! Multiple funded postdoctoral positions are available on projects at the intersection of bioinformatics, evolution, genetics, and electronic health records. Please share!.

I am excited to share our recent work published in @GenomeBiolEvol. We report that human enhancers have both ancient cores and recently evolved DNA. This combo is important for enhancer activity and functional variation across human populations. Check it out!.

RT @CrunchyNeuroSci: Thrilled to share that our beat synchronization GWAS is featured on the September 2022 cover of @NatureHumBehav! This….

RT @CreanzaLab: The genomics of musical beat synchronization out in @NatureHumBehav -- beautiful artwork and a really fun collaboration! @C….

Thanks! Congrats to @Arcane_Asunder!.

Check it out and let us know if you have questions. Scores and code available here: . And a web app here: 

We find pervasive 3D constraint and demonstrate that incorporating the structural perspective improves performance at several variant interpretation tasks. We hope that COSMIS will complement existing methods for interpreting protein-coding variation in evolution and disease.

Led by @computbiolgeek and in collaboration with the @rodendm lab, we used 3D structures from the @rcsbPDB, #AlphaFold, and SwissModel to quantify constraint on 6.1 million amino acid sites in 16,533 human proteins via a COntact Set MISsense tolerance (COSMIS) score.

I am very pleased to (belatedly) share the publication in @NatureComms of our recent work integrating population genetic and protein structural perspectives to quantify mutational constraint in 3D.

Heroic effort led by @CrunchyNeuroSci to study the genetic architecture of musical rhythm!.

RT @CrunchyNeuroSci: We are very excited to share our newest #musicscience findings on the genetic architecture of musical rhythm, publishe….

Check out this thread on new work lead by @abin_abe and @Lab_LaBella from the @RokasLab to quantify evolutionary signatures on genomic regions associated with traits from hundreds of GWAS. And @abin_abe has put together a package if you want to try it out yourself!.

Check out our lab manuscript template for some tricks, tips, and preferences (in both LaTeX and MS Word). Hoping it can be helpful to others! 🗒️✍️.

RT @EvonneMcArthur: Experiencing a rollercoaster of emotions since defending my PhD. But these faces capture the best one, pure JOY!!🤗🍾I co….

Check out our preprint and @EvonneMcArthur's thread below. We apply deep learning to reconstruct Neanderthal and Denisovan 3D folding patterns and then ask some cool questions about how this might have affected recent human evolution!.

RT @benoitbruneau: What? 3D chromatin organization in Neandertal and Denisovan genomes! From my @GladstoneInst and @UCSF colleagues in Tony….

RT @colinmbrand: Brilliant new preprint from the @capra_lab and the Pollard lab on the 3D genome organization of a Denisovan and three Nean….

RT @cedricboeckx: Nice new work by @EvonneMcArthur @capra_lab and colleagues further probing changes in gene regulation between us and our….

Excited to share new preprint on work done by Sarah Fong (@slifong) exploring the evolution of human enhancers with multiple sequence ancestors and relationships to gene regulatory function and selection pressures.

Excited to share our latest work with an amazing team, @ChazinWalter @alexmblee and @ZacNagel lab, on improving tumor #VUS interpretation with an active learning strategy: