Greg Fonzo
@GregFonzo
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Assistant Professor at Dell Medical School, UT Austin. Researcher of trauma, anxiety, depression, stress, neuromodulation, and psychedelics.
Austin, TX
Joined July 2019
RT @DellMedSchool: New research from #DellMed's @GregFonzo "opens a new frontier" in the use of non-invasive deep brain stimulation for psy….
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RT @TanParkerTX: Compelling testimony in committee from @w_bryan_hubbard of the American Ibogaine Initiative, Navy Cross recipient and reti….
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This was a huge team effort! Big thanks to the X-less Lauren Enten, Annie DeMarco, Rachel Kline, Charles Nemeroff, Bryan Barksdale, & X-friendly @ManojDoss. Excited to see the next set of papers on amygdala FUS from @NoahSPhilipMD!.
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These findings open up new possibilities for non-invasive #brain-based treatment of a whole family of psychiatric disorders characterized by abnormal amygdala function. Though the FUS/fMRI findings were double-blind, we need to replicate clinical effects in an RCT.
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There was also an anger-specific attenuation in the left amygdala, nearly overlapping with the region we demonstrated attenuation with concurrent FUS/fMRI. This suggests some of the observed effects may be related to FUS vs. repeated measures/habituation only.
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We also probed amygdala function using emotional faces with task-based fMRI in patients before and after daily FUS. We see the expected attenuation in amygdala activation across all task conditions. No comparator, so take it with a grain of salt--but still looks promising!
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Several secondary outcomes survived Bonferroni correction, including measures of depression, anxiety, and PTSD symptoms.
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We saw a notable attenuation in symptoms, including our primary outcome as well as several secondary outcomes.
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Quieting the amygdala has been considered by some as the "holy grail" of psychiatric neuromodulation. We tested this in patients by delivering the same FUS protocol once daily for 3 weeks in an open-lablel design using MRI-guided neuronavigation.
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We first began with establishing target engagement using concurrent FUS delivered during fMRI. We targeted the left amygdala and demonstrated an acute inhibition of BOLD signal across patients and healthy controls that was similar in magnitude.
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Our focused ultrasound (FUS) #neuromodulation paper now out in @molpsychiatry! Low-intensity FUS attenuates #amygdala fMRI BOLD signal. Broad therapeutic effects in patients with once-daily FUS. Next up, the RCT!. Thanks to @OneMindOrg, who funded this!.
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The manager of the hotel could not even tell me what the detector is measuring, nor when it was last calibrated. Absolute predatory practice. I didn't even know about the charge until I got an automated credit card alert. I had to go inquire about it. Terrible, terrible hotel.
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Honored and grateful to Gordon and Charmaine McGill and the Cain Foundation for their $12.5+ million commitment to the McGill Center for Psychedelic Research and Therapy at @DellMedSchool @UTAustin. Big thanks to @gpoler for making this possible!🤘.
dellmed.utexas.edu
Charmaine and Gordon McGill, through their family’s Cain Foundation, have committed more than $12.5 million to the Center for Psychedelic Research and Therapy.
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RT @DellMedSchool: "What is the special sauce here that results in clinical efficacy? Is it the drug, the therapy, or the combination?" . R….
psychiatryonline.org
PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.
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RT @ManojDoss: If you’re at #ACNP2024, check out our posters on focused ultrasound on Tuesday night. I’ll specifically be trying to explain….
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Applications close Nov 7th 5pm ET for the @ADAA_Anxiety Career Development and Leadership Prog! Get mentorship/training from those leading the charge to combat anxiety, depression, and related conditions. @jamie_micco @DrKrystalLewis @DrSeligowski.
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Join me in Vegas this spring at the @ADAA_Anxiety annual conference! For early career investigators, apply for the Career Development and Leadership Program. Stellar mentors to help you navigate early career issues. Deadline is Nov 7th!
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From a CDLP Alum: Be sure to apply for the educational award opportunities available at this year’s @ADAA_Anxiety conference. Applications open until November 7th! Apply at:
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RT @DellMedSchool: Want to see #DellMedDoctors at next year's @sxsw? Experts & proposed topics include @GregFonzo & Charles Nemeroff on psy….
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