PI of the Rezvani lab. Researching NK cells' role in mediating protection against cancer and strategies to enhance their killing function. Views are my own.
We are thrilled to announce that our paper on CAR-NK cells is now online on NEJM! Off-the-shelf CD19.CAR-NK cells induce remarkable responses in B-cell malignancies. Great news for our patients with these promising results!
@NEJM
@MDAndersonNews
Please check out our paper published in
@NatureMedicine
on our Phase I / II trial with cord blood CAR19/IL15 NK cells. We report promising 1 year PF and OS rates of 32% and 68% in patients with relapsed / refractory B cell malignancies (with a median of 4 prior lines of…
Thank you, I am honored and humbled by this recognition, and deeply grateful both to my wonderful team for all of their hard work, and to MDACC for their unwavering support. Together, we will continue our mission to make cancer history
@MDAndersonNews
#ASH23
#EndCancer
Congratulations to our Dr. Katy Rezvani on receiving the 2023 E. Donnall Thomas Lecture and Prize by
@ASH_hematology
for her groundbreaking research in the development of novel cell therapies using NK cells.
@lab_rezvani
#ASH23
#EndCancer
There is nothing more amazing in one’s career than having a preclinical concept translated to the clinic. Congratulations
@lucila_kerbauy
, everyone in the lab, the MDACC cord bank and GMP, and especially Dr Nieto and the clinical team.
@ScienceMagazine
@MDAndersonNews
#AACR2022
Thank you very much Dr. Brodsky
@DocsDock200
for your very kind words! It was such an honor to receive this award from ASH. Please accept my sincere congratulations for presiding over such an amazing
#ASH23
@MDAndersonNews
Delighted to report our paper in JCI: CRISPR KO of TGF-βR2 in NK cells enhances their activity against GBM. Great collaboration with Amy Heimberger,
@FrederickLangMD
. Congrats Hila, Mayra,
@rftbsr9
. Looking forward to the clinical trial
@MDAndersonNews
I am very excited to present these data at the major symposium on NK cells at AACR 2021 with a live discussion on Tuesday April 13th
@AACR
@MDAndersonNews
Excited to be heading to New Orleans
#AACR22
! Please join us at 10am Saturday for our NK Cells session, with talks on NK engineering, NK engagers, and NK vs CAR T with
@EricVivier1
, Yvonne Chen, and
@lab_rezvani
@MDAndersonNews
Our manuscript on generation of CRISPR gene edited SARS-Cov2 specific T cells for immunotherapy of COVID19 is prepublished
@biorxivpreprint
. Congratulations
@rftbsr9
, Nadima, Emily and our collaborators. Looking forward to the clinical trial
@MDAndersonNews
MD Anderson and Replay announce that the FDA has issued a ‘safe to proceed’ for a first-in-human Phase I study of an engineered TCR NK cell therapy for
#sarcoma
.
Learn about it here:
@lab_rezvani
@replaybio
#EndCancer
Sharing our lab’s congratulations for my stellar student Ye Ethan Li who passed his PhD with flying colors! Ethan’s thesis on CAR NK engineering to overcome relapse was published in Nat Med Looking forward to your continued success
@MDAndersonNews
@yl668Li
Delighted to report the result of our clinical trial of off-the-shelf BKV CTL in 59 patients with BKV hemorrhagic cystitis after allo-HSCT with a RR of > 80%. Congrats Amanda Olson MD, SCT faculty, our research nurses, & our GMP facility
@MDAndersonNews
Incredibly proud of Ye Ethan Li for having his PhD project published in Nat Med. His paper shows that trogocytosis drives relapse post CAR NK therapy & that modulating NK signaling can improve CAR NK efficacy. Congratulations Ethan!
@KenChen
@UH_NVLab
Honored to present at the NK symposium
#AACR21
with
@CerwenkaLab
and
@LabFehniger
. I will share our work with NK cell engineering, and early clinical data on adoptive therapy using NK cells complexed with an engager in Hodgkin lymphoma. Live Q&A 4/13/21 12.30pm ET
@mdandersonnews
Congratulations to Dr. Nieto and collaborators on the outstanding clinical data with AFM13-NK cells in 19 patients with relapsed or refractory Hodgkin Lymphoma, reporting 89% ORR, including 10 complete responses.
@AACR22
press conference;
@MDAndersonNews
The first presenter in today’s press conference is Yago Nieto, MD, PhD, from The University of Texas MD Anderson Cancer Center, presenting results from a phase I/II clinical trial.
@MDAndersonNews
#AACR22
Please check out our paper on
#NK
cells precomplexed with AFM13 enhancing NK activity against CD30+ lymphoma
@ccr_aacr
. Great collaboration with
@LabFehniger
. Congrats
@lucila_kerbauy
& Nancy. This preclinical work is the rationale for our ongoing clinical trial
@MDAndersonNews
Genetic deletion of CIS, an NK immune checkpoint, enhances both the anti-tumor activity and metabolic fitness of IL15 expressing cord blood-derived CAR NK cells is now online.
Congrats May, Rafet and the rest of Rezvanilab
@may_daher
@rftbsr9
#endcancer
Please check out our paper published in
@ScienceAdvances
describing loss of metabolic fitness as an important mechanism of CAR NK cell dysfunction, which can be partially overcome by cytokine engineering. Grateful for the collaboration with
@kchenken
.
#NK
A study led by
@kchenken
and
@lab_rezvani
uncovers a key mechanism of tumor resistance and finds anti-tumor activity improved by engineering CAR NK cells with interleukin-15.
Learn about these findings published in
@ScienceAdvances
.
#EndCancer
Outstanding presentations by
@may_daher
&
@Byersdoc_BMT
at the Immunometabolism as a tool to advance cell therapy session
#ASH23
describing novel strategies to modulate and enhance the potency of immune effector cells for adoptive therapy
@MDAndersonNews
GMP compliant CRISPR edited glucocorticoid resistant viral-specific T cells developed by our group (led by Drs. Basar and Daher) and supported by the MD Anderson Moonshot program.
Looking forward to the clinical trial
@MDAndersonNews
#CancerMoonshot
Excited to be traveling to ASCO, where I will be sharing long term follow up data on our CAR19 NK cell trial during the ED session on pediatric immunotherapy: CARs of the future in room S504 4.30pm Sunday June 4th with
@eddie_cliff
Yvonne Chen
@MDAndersonNews
#ASCO23
#nk
Please join me at
#SITC2022
at the Cellular Therapies + Bispecifics session on Thur 10th Nov at 4.40pm where I will be updating on our
#NK
Cell program. Honored to present with Drs. Yvonne Chen, D. Atanackovic, D. Miklos,
@dimitrisskokos
@ S Pal. See you then!
@mdandersonews
We are thrilled to announce that our paper on CAR-NK cells is now online on NEJM! Off-the-shelf CD19.CAR-NK cells induce remarkable responses in B-cell malignancies. Great news for our patients with these promising results!
@NEJM
@MDAndersonNews
Outstanding presentation by Dr. Sunil Acharya
@sunilacharya13
on his work with CD70 targeting CAR constructs at the
#NK2023
meeting in Oslo. Incredibly proud of his achievements, which have now been translated to the clinic
@MDAndersonNews
#nk
#endcancer
Excited to report that our special issue on NK cells with contributions from leaders in the field is now in press in Seminars in Hematology.
@Fer_NK_nando
@LabFehniger
@may_daher
We are deeply humbled by the Goradia family’s extraordinary donation for our CD70 CAR NK program. Their incredible generosity will allow patients with cancer to receive transformative CAR NK therapy, and support research into other innovative cancer treatments.
@MDAndersonNews
#NK
“We’re all hoping for the same end result: Making Cancer History®," says kidney cancer survivor and philanthropist Vijay Goradia of his $10 million gift to support cancer research at MD Anderson. Learn his story:
@lab_rezvani
#EndCancer
Delighted to be on my way to EBMT in Paris! Looking forward to sharing exciting initial data from our CD70 CAR NK clinical trial at the plenary session on “Non-CAR T cell Therapies’ on Tuesday April 25th.
@MDAndersonNews
@TheEBMT
#EndCancer
#NK
Awe-inspiring keynote by Prof Angela Santoni hailing both 50 years of NK cell research and the field’s icons who made the seminal discoveries.
#NK2022
@SNI_NKMeeting
#nk
Very proud of Ye Ethan Li for having his PhD project published in NatMed. His paper shows that trogocytosis drives relapse post CAR NK therapy & that a dual CAR system to modulate NK signaling can improve CAR NK efficacy. Congratulations!
@MDAndersonnews
Researchers from our Dr. Katy Rezvani’s lab identified a novel mechanism of relapse following chimeric antigen receptor natural killer cell therapy and developed a strategy to mitigate this process:
@Lab_Rezvani
#CARNK
#EndCancer
Please also check out this Nature Briefing article that provides further insights into the background of our CAR NK trogocytosis paper & the dual targeting approach applied to modulate NK signaling
@MDAndersonNews
@NatureMedicine
Congratulations to
@may_daher
, a star in the field of cell therapy at MDACC for being selected as a Sabin Fellow for her innovative approach to NK cell engineering. May, I am so proud of you!
@MDAndersonNews
#endcancer
The Andrew Sabin Family Foundation’s generosity continues to touch many lives as our Sabin fellows work to improve outcomes for those who are affected by cancer. We are deeply appreciative of this important partnership and its tremendous impact.
#EndCancer
Important study showing the promise of locoregional delivery of CAR T cells in glioblastoma. Congratulations to Christine Brown and co-authors
@cityofhope
@NatureMedicine
#ASH22
Looking forward to
#ASH2022
. Please join me Fri Dec 9th
@2pm
for the Workshop on Gene Editing chaired by Drs. Rio and Porteus. I will be sharing the progress made in our clinical trials of CAR NK and CRISPR-edited
#NK
cells
@MDAndersonNews
Looking forward to chairing the clinical trials mini symposium
#AACR2021
today 3.30 pm ET. Please join us for a fantastic lineup of speakers.
@MDAndersonNews
Outstanding data on a multicenter study KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma published in NEJM led by Michael Wang and colleagues. Of 74 patients enrolled, 85% responded with 59% achieving complete response.
Congratulations
@HindRafei
!! An outstanding presentation by a superstar member of our team! So excited about your project to enhance the potency of NK cells against solid tumors, and looking forward to translating your work to the clinic.
@MDAndersonNews
@BMDACCstemcell
So excited to be in Florida for
#nk2022
Please join us for the NK cells in the clinic workshop tomorrow at 8.30 am with presentations by leaders in the field. Looking forward to the first face to face NK meeting since Luxembourg 2019!
@MDAndersonNews
@SNI_NKMeeting
Congratulations
@HindRafei
for your outstanding presentation today at
@ASHIHQ
! I’m so proud of everything that you’ve achieved in the lab; everyone is looking forward to what is undoubtedly a very bright future ahead of you!
@MDAndersonNews
#ASHI2023
Deeply grateful to the SU2C MEG VOSBURG T-CELL LYMPHOMA DREAM TEAM for supporting our CAR NK program to target CD5. And thrilled to share FDA clearance for a clinical trial targeting CD5 CAR NK cells in patients with T cell lymphoma.
@SU2C
@MDAndersonNews
@CAGTHouston
Delighted to report the publication of our paper on the generation of glucocorticoid knockout SARS COV2 CTLs for severe covid19. Congratulations
@rftbsr9
Nadima, Emily and Rezvani Lab. Trial data with SARS COV2 CTLs to follow
#COVID19
@MDAndersonNews
Cord blood CAR NK cells targeting CD5 with optimized intracellular signaling are highly effective against T cell malignancies in preclinical models. We are grateful to
@SU2C
for the support. Looking forward to the clinical trial
@rftbsr9
;
@may_daher
;
@MDAndersonNews
Really looking forward to 4 days of in-person meetings focusing on NK cells. Much to learn from, and share with, friends and colleagues on NK cell biology and application for cancer immunotherapy. Join us May 14th!
@SNI_NKMeeting
@MDAndersonNews
#nk
A morning of the latest on NK cell therapeutics! You can still register to access the live stream and participate in Q and A if you missed out attending the SNI NK2022 meeting in person!
@lab_rezvani
@EricVivier1
#NKcell
#CARNK
Elegant paper on mechanisms of resistance and responsiveness to CAR T cells in glioblastoma
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
Please join me and my fellow panelists on Wed Nov 10 from 2-6 pm ET for
#SITC21
Pre-conference on The Evolution of Immunotherapy: Immunity Beyond T cells, CAR T in Solid Tumors and Novel Combinations; with a fantastic line up of speakers
#immunotherapy
.
Fantastic
@SNI_NKMeeting
Gala Dinner with the Dream Team
@lab_rezvani
. Amazing meeting
@MalmbergLab
et al 👏👏👏👏 The NK cell field charging on! Real clinical progress being made. Big fundamental breakthroughs being shared. NK cell community are such an inspirational bunch 🥰🤗
Delighted to report that our article: Adoptive cell therapy- Living drugs against cancer is now in press
@JExpMed
- Found in Translation. In this article Tamara Laskowski’s and I discuss the latest advances in cell therapy.
@MDAndersonNews
@Gaia_JExpMed
Please check out our recent review in Cancer Discovery on NK cell Engineering
@may_daher
. In the same issue checkout an outstanding review on NK cells and the immunosuppressive tumor micro environment by
@EricVivier1
and colleagues
Happy to share our review on alternative CAR vehicles with a focus on
#CARNK
cells in Cancer Discovery
@CD_AACR
. In the same issue checkout a review on tumor infiltrating NK cells by
@EricVivier1
!
@lab_rezvani
Many congratulations
@may_daher
! I am incredibly proud of all that you have achieved, and I am very much looking forward to seeing you continue to make a difference to our patients as a result of your dedication to your research.
@MDAndersonNews
I am deeply humbled and honored to have received a Faculty Scholar Award. Huge thanks to my amazing mentor
@lab_rezvani
for nominating me and for her unwavering support throughout the years. Thanks to
@ppisters
@CarinHagberg
for this special celebration event!
@MDAndersonNews
So looking forward to the Immune Metabolism as a Tool to Advance Cell Therapy session co-chaired by
@may_daher
Sunday 12/10 at 4.30pm in SDCC - Room 11. Hope to see you there.
#ASH23
@MDAndersonNews
An awe-inspiring keynote presentation by Dr. Lewis Lanier at
#NK2023
meeting in Oslo. Immensely grateful for the amazing contributions of this giant of the field of NK Cell Biology
@SNI_NKMeeting
@MDAndersonNews
#NK
#CARNK
Congratulations to Dr. Uday Popat from the Department of Stem Cell Transplant
@CancerMedMDA
for being awarded the best abstract in clinical research at
#TCTM20
for his innovative approach to SCT- less TRM, less relapse and survival for our patients with high risk leukemia
Very much looking forward to this exciting Women in Cancer Event! Please do join us on Fri June 2nd in Chicago at what will be a very interesting and rewarding event.
@ca_chung
#womenincancer
Excited 🤩 to share our latest review on current trends and evolving concepts to genetically engineer the next generation of CAR-NK immunotherapies together with my amazing mentor Dr. Katy Rezvani.
@lab_rezvani
@MDAndersonNews
Many congratulations to
@may_daher
, a star in the field of cell therapy and a key leader in our translational CAR NK cell program at MDACC. May, I am so incredibly proud of you!
@MDAndersonNews
#endcancer
Many congratulations to Dr. Rafet Basar
@rftbsr9
from our group for being selected as a STAT Wunderkind 2020, awarded every year to the brightest young minds in North America for their work in academia, industry, and in the clinic.
#statsummit
#EndCancer
Congratulations to our Rafet Baser on being selected as a STAT Wunderkind for his work in trying to limit side effects in cell-based therapies.
#STATSummit
#EndCancer
Delighted to share our latest review of the next generation CAR T and NK cells for cancer immunotherapy in Immunological Reviews with
@lab_rezvani
and
@Yl668Li
! Kudos to Ethan for his outstanding work on this!
@MDAndersonNews
#NK
#CAR
Looking forward to the
#NK2022
meeting, starting on May 14 with a special
#NKcells
in the clinic session and round table discussion. Abstract submission is now open!
Excited to announce that the
#NK2022
meeting will kick off Saturday morning May 14 with special
#NKcells
in the clinic sessions and round table discussion, excited about the progress in
#nkcell
therapy! See you in sunny Florida
What an amazing video by
@goharmanzar
, using her love of music to connect with her patients:
It has been such a pleasure to co-mentor Gohar together with
@may_daher
, and also to follow her incredible talent and career trajectory. Very excited to continue…
Congratulations
@skopetz
! I can’t think of anyone more qualified for this important role, and I look forward to continuing our collaborations together in the future.
@MDAndersonNews
Congratulations
@skopetz
👉🏽 our new Associate Vice President for Translational Integration at
@MDAndersonNews
!
Scott is the perfect physician scientist to spearhead the role of bringing together discovery & applied research efforts across our institution. 🙌🏽
Congratulations
@rftbsr9
for an outstanding presentation! So proud of all that you’re achieving, and looking forward to what the future holds for NK Cell Therapy
#ESHCLL2024
@MDAndersonNews
🌐
@rftbsr9
introduces the versatile world of CAR-NK cells at
#ESHCLL2024
, spotlighting their benefits in treatment strategies, not just for
#CLL
but potentially beyond. With the capacity for various modifications and combinations, CAR-NK cells open new avenues in immunotherapy.
It's been a fantastic journey from a bench discovery to a Phase 1 trial led
@CAGTHouston
by
@HillLaQuisa
and Rayne Rouce. Excited for new options for in T-cell malignancies and look forward to the upcoming Phase 2.
Thank you
@NathanSinghLab
for traveling to see us and your inspiring presentation. The team and I loved having you visit and were so impressed by your outstanding work and impressive data. Really looking forward to our collaboration!
So thankful to
@lab_rezvani
for such a great trip! Amazing science, gracious hosts and such a fun group of researchers. Katy has cooked up something really special down in Houston. The last two days felt like a vacation!
Exciting data from Christine Brown's group at City of Hope.
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma
Congratulations!!!
Dr May Daher, Assistant Professor in the Section of Cell Therapy, Dept SCT at
@CancerMedMDA
chairing an exciting abstract session on Immune and Gene Therapy at
#TCTM20
Congratulations Marco and Nathan on an outstanding paper showing the potential positive impact of tonic signaling on CAR T activity
@MarcoRuella
@NathanSinghLab1
Please join today's SITC Virtual Workshop on 'Engineering Immune Cells for Cancer Therapy' with presentations by Dr. Rosenberg 'Cellular therapy for Metastatic Cancers',
Dr. Hanaan 'Adoptive Therapy using TILs' and
Dr. Yee 'Endogenous T cell Therapy for Solid Tumors
#sitc2020
Our paper on IL-12 and IL-23 is out today in
@CellCellPress
! Using structures of the IL-12 and IL-23 receptor complexes, we engineered versions of IL-12 that support T cell anti-tumor immunity without NK cell toxicity
Grateful to
@TSAPhysicians
for this shout out! Deeply honored to be recognized by the Texas Women’s Hall of Fame
@GHWCC
. Advancing and empowering women in leadership, education, advocacy and mentorship is crucial. Together, we can continue to pave the way for women.
#gratitude
Congratulations
@kchen_lab
and Rui_chen Lab for this exciting work on de novo integration of two
#SingleCell
technologies and thank you for the fantastic collaboration
@MDAndersonNews
So proud of David
@DontheFirst
who was an outstanding CPRIT summer intern in the
@lab_rezvani
@MDAndersonNews
for winning the prestigious Goldwater Scholarship! Great things are waiting for you! 🤩🎉🎊
What a great day this has been! Congrats
@AlvaroHaroun
on the brilliant defense of your PhD thesis at the Karolinska Institute. A million thanks to
@lab_rezvani
for your outstanding work as opponent via zoom.
Looking forward to the AACR virtual meeting. Sessions will be streaming continuously from 9:00 am-6:00 pm EDT, April 27-28, with exciting updates on adoptive cell therapy trials. In addition, a session dedicated to COVID19 and cancer will stream tomorrow 9-11 am EDT.
We are happy to announce that
@lab_rezvani
is recruiting synthetic biologists and vectorologists. If you have the credentials and want to join a great team and have fun doing science let us know!
#syntheticbiology
#vectordesign
#NK
Congratulations to my talented postdocs Gabi and Colleen on this tour de force study in
@NatImmunol
on the coordinated epigenetic and transcriptional regulation of mouse and human NK cells by cytokines and STATs.
@may_daher
@rftbsr9
Very proud of you Rafet
@rftbsr9
You are a superstar and I have no doubt will continue to contribute to the field for many years to come. Congratulations Assistant Professor Rafet Basar
Outstanding presentation by Dr. Frangoul at
#ASH20
plenary session this am on
#CRISPR
-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia | published in NEJM
Elegant work by
@EricVivier1
and colleagues on the role of the complement C5a-C5aR1 axis in
#COVID
ー19 associated ARDS - now published in
@Nature
. Targeting C5aR1 with an antibody prevented myeloid recruitment/activation and lung injury in a relevant mouse model. Congratulations!
It is an honor to receive this award named after a giant in leukemia research and a great mentor to me by another giant and mentor
@DrHKantarjian
at
@SocietyofHemOnc
.
We are excited to share our recent paper with the title “Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory”, led by
@TimoRckert
, in which we study the origin and maintenance of human adaptive NK cells!
The honor is ours to have our paper published side by side with such a pioneer and leader in innate immunology as
@EricVivier1
. Building on your major contributions to the basic understanding of NK cell biology has been pivotal for the field of NK immunotherapy for cancer.
@lab_rezvani
@may_daher
Thrilled and honored to have our piece on tumor infiltrating NK cells published back-to-back to your great review on CAR-NK. Harnessing NK cells is a way for the 2nd wave of cancer immunotherapy