Having been inspired by the intense world of 𝘌𝘙 to trade her life as an aspiring writer for a medical career, a trainee lands in a hospital that the TV show was based on — but not in exactly the role she expected. Read the Perspective by Elizabeth Rourke, MD:

𝐂𝐞𝐫𝐞𝐛𝐥𝐨𝐧 (𝐂𝐑𝐁𝐍) is the substrate-recognition subunit of an E3 ligase complex, a complex that ubiquitinates specific protein substrates, marking them for proteasomal degradation. A hydrophobic pocket in cereblon can interact with drugs such as thalidomide,

Nancy Tomes, PhD, discusses the century-long transition to a corporate business model in U.S. health care. Listen to the full interview with NEJM Executive Managing Editor Stephen Morrissey (@srm128):

Weekend Briefing for August 9, 2025: . New Images in Clinical Medicine: Ocular Gnathostomiasis . Two New Perspectives: . 1️⃣ Private Law in American Health Care . 2️⃣ The Serendipitous Dance between Life and Death.

Correspondence by Martin Burtscher, MD, PhD: Xenon — Propelling Climbers to the Summits of the World’s Highest Mountains? #Pulmonology #CriticalCare

For patients with bubonic plague in Madagascar, oral ciprofloxacin alone may be an effective alternative to an injectable aminoglycoside plus oral ciprofloxacin. Research findings from the IMASOY trial are summarized in a new Quick Take video.

Original Article: Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (CONFIDENCE trial) . Editorial: Combination Therapy for Chronic Kidney Disease and Type 2 Diabetes — A Promising Prelude . #Endocrinology

In the latest Perspective in the Corporatization of U.S. Health Care series, Nancy Tomes, PhD, writes that understanding today’s corporatization of U.S. health care requires seeing it from a historical perspective, as a process that began with a change in the business model of

A woman receiving immunosuppressive therapy for rheumatoid arthritis presented with a 2-month history of an itchy rash. Large patches of erythematous skin with overlying scales, crusting, and deep fissures were seen across the body. Read the full case details in the Images in

A 32-year-old woman presented with fatigue, myalgias, and palpitations. The cardiac rhythm was irregularly irregular, and an electrocardiogram showed findings suggestive of grouped beating. What is the most likely diagnosis in this case? . 🗳️ Cast your vote before August 21:

Science behind the Study: Degradation of the Estrogen Receptor in Breast Cancer . #Oncology #Genetics

A previously healthy 47-year-old woman presented to the neurology clinic with a 1-month history of worsening headaches associated with blurry vision, galactorrhea, and irregular menstrual cycles. Physical examination was notable for reduced visual acuity of 20/50 in both eyes,

The authors of a new Perspective argue that to prevent the spread of inaccurate information, academic and health care institutions will need to equip scientists and clinicians to engage effectively on nontraditional media platforms. Read the full Perspective:

A 76-year-old woman with a history of smoking, diabetes mellitus, and hypertension presented to the hospital with dyspnea. She also had weakness that had progressed during the previous several months. Read the full case details:

Although xenon may have neuroprotective effects, there is no strong evidence that it aids in short-term, high-altitude performance, writes Dr. Martin Burtscher in a letter. Success is more likely a result of acclimatization, oxygen support, and favorable conditions.

New in the August 7, 2025, issue of NEJM: . Finerenone with Empagliflozin in CKD and Diabetes (CONFIDENCE trial) . Ciprofloxacin Monotherapy for Bubonic Plague (IMASOY trial) . Vepdegestrant in Advanced Breast Cancer (VERITAC-2

RT @NEJMEvidence: Surgical insertion of a revakinagene taroretcel implant into the vitreous cavity of participants’ eyes with macular telan….

A 27-year-old man with e-cigarette use presented with a 5-day history of fever, vomiting, diarrhea, dyspnea, and hemoptysis. A radiograph and CT scan of the chest showed patchy consolidations in both lungs. Read the full case details in the Images in Clinical Medicine article

Shalender Bhasin, MB, BS, and Peter J. Snyder, MD, review available data on the benefits and risks of testosterone treatment in middle-aged and older men with moderate hypogonadism. Learn more in the Review Article “Testosterone Treatment in Middle-Aged and Older Men with

Donald P. McDonnell, PhD, describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer. Learn more in the editorial “Degradation of the Estrogen Receptor in Breast Cancer”