BevanLab
@lab_bevan
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Basal ganglia lab with a focus on neurons, synapses, and circuits in health and mouse models of Parkinson's disease and Huntington's disease. Tweets by Mark.
Chicago
Joined March 2020
3-year CHDI-funded postdoc available immediately to investigate somatic instability-dependence of basal ganglia dysregulation in Huntington's disease mice. Experience in electrophysiology/circuit interrogation/mouse behavior ideal. Please contact: m-bevan@northwestern.edu
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Online now: The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions https://t.co/wSaIHdJuo7
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Congrats to Kim Reinhold, soon to launch her own group in the Eaton Peabody Labs, on this labor of love. Basically, she shows that the visually recipient zone of the striatum mediates outcome-dependent trial to trial updates of behavior. https://t.co/kDSBN1yRdf
nature.com
Nature - Activity in the striatum is necessary for trial-to-trial improvements in learning sensory–motor tasks but not memory recall.
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Thank you so much to @BirnbaumJackie1 and @MunibHasnain for presenting their recent paper today at @CMU_Bio @cmuneurosci Exciting approach to understand how to explain neural data and movement https://t.co/oRzThiKjRo
nature.com
Nature Neuroscience - Using a novel method for isolating cognitive and motor neural dynamics, the authors show that dynamics often attributed to cognitive processes were corrupted by movements and...
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The latest work from the Lammel lab is out today in @Nature! Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭 https://t.co/zGeXCGaHXr
nature.com
Nature - In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding...
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Striatal cholinergic interneurons act at nAChRs to depress #dopamine release, supporting an inverse scaling of dopamine release according to cholinergic activity https://t.co/s2vdUwdS1v
nature.com
Nature Neuroscience - Cholinergic interneurons act at nicotinic receptors to depress dopamine release, interrupting its relationship to dopamine neuron firing and supporting an inverse scaling of...
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Proud to have contributed to @JiaxuanQi's masterpiece out @Nature! She shows dopamine transients track the quality of song during juvenile song learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism!
nature.com
Nature - Dopamine release in the basal ganglia of the zebra finch is driven by neurons associated with reinforcement learning and by cholinergic signalling, and tracks performance quality during...
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How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint): https://t.co/Ztrjfybfqj
biorxiv.org
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and...
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Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation
cell.com
Neurofilament light chain (NfL) is a commonly used biomarker in neurodegenerative disease. Kahn et al. describe the mechanism of release from degenerating neurons. They also demonstrate that loss of...
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Science Matters. 🧪🔬🚀 I am alive because of science. We all benefit from science — every day. Science is in our homes, our hospitals, our streets, our work. For 80 years, science and technology have been a north star for the United States. In 1945, Vannevar Bush’s report to
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NIH Brain Initiative funded multiple studies on closed loop brain stimulation for a number of neuro/pscyh conditions including Parkinson Disease. Now FDA approval granted for device that adjusts stimulation based on a person's neural activity.
medpagetoday.com
Closed-loop system adjusts stimulation to individual brain activity in real time
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I am thrilled to share my postdoc work from the Soohyun Lee Lab, https://t.co/iEF9fpTBuZ. Huge thanks to the awesome PI Soohyun Lee and collaborators Yuan Zhao, Ka Chun Lam, @fpereira, and Charles R Gerfen.
nature.com
Nature - Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with...
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Major breakthrough in pancreatic cancer . Funded of course by the @NIH
Huge cancer breakthrough! mRNA vaccine (similar to COVID vaccine tech) shows stunning results against pancreatic cancer! 75% of responsive patients STILL cancer-free at 3 yr, normally 80% recur. Could revolutionize treatment for one of deadliest cancers! Funded in part by @NIH
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🚨📃New Wassum Lab Paper📃🚨 @Jackie_Gio discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 https://t.co/cjM6W5Apja... Free full text:
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Coordination between ESCRT function and Rab conversion during endosome maturation Anne Spang and colleagues @Spang_Lab @biozentrum show that early ESCRT complexes shepherd cargoes towards sites of intraluminal vesicle formation https://t.co/ghDretQBoM
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A comprehensive longitudinal analysis of individuals with preclinical #HuntingtonsDisease identifies #biomarkers of #neurodegeneration and somatic expansion in blood DNA, detectable years before symptom onset. @DrMFarag @UCLHD @UCLIo
https://t.co/3desiwYgKc
nature.com
Nature Medicine - A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA,...
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G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
cell.com
Stykel et al. show that G6PD missense mutations increase the risk of PD diagnosis and that α-syn accumulation leads to G6PD dysfunction and deposition into Lewy bodies. This leads to loss of redox...
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Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyu_chang! https://t.co/ok9iR01pnl
https://t.co/zicNX2JEed
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Dendritic Integration Symposium next Tuesday Dec 10th. Online. Free. Great speakers !
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