Mena Farag
@DrMFarag
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Neurology south London trainee 🧠 (OOP-R; ST6) ⋅ PhD candidate @UCLIoN — #HD-YAS 𝕏 @UCLHD
London
Joined February 2022
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @MDJ_Journal on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 Open access link: https://t.co/CepJ9GtLuu
@UCLHD
movementdisorders.onlinelibrary.wiley.com
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides...
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I am incredibly honoured to share that I have been awarded the @UKDRI PhD Prize at #Connectome 2025! My heartfelt thanks go to my superb PhD supervisors (Professors Sarah Tabrizi, Rachael Scahill and Ed Wild) and to my thesis committee (Professors Geraint Rees and Henrik
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Huntington's disease clinical trials update: October 2025 https://t.co/7RvSwbzbnv
#HuntingtonsDisease $QURE etc.
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Check out the October 2025 edition of the #HD Clinical Trials Update, now published in @journal_hd and available online! 🔗 https://t.co/YhqMXeI6Dn
@UCLHD @UCLIoN @UCLBrainScience
journals.sagepub.com
In this edition of the Huntington's Disease Clinical Trials Update, we expand on the launch of the phase II/III clinical trial of SKY-0515 from Skyhawk The...
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A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. https://t.co/Se4XnZyuNE
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Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
movementdisorders.onlinelibrary.wiley.com
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides...
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@MDJ_Journal @UCLHD For the first time, we show that baseline CSF PENK predicts longitudinal striatal atrophy and also outperforms NfL in distinguishing HD-ISS 0 vs 1, supporting CSF PENK as a striatum-specific biomarker to enrich early HD trials and inform future preventive trial design.
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This is why we fund science.
Huntington's disease has been successfully treated for the first time, doctors tell BBC
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Such brilliant news for families affected by Huntington’s disease and for researchers. This is a moment of real hope.
bbc.com
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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Huntington's disease has been successfully treated for the first time, doctors tell BBC
bbc.co.uk
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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Huntington's disease successfully treated for first time
bbc.com
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @UCLIoN @UCLHD
https://t.co/KJtNtp12NJ
bbc.co.uk
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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Vesicular monoamine transport inhibitors: current uses and future directions - The Lancet
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VMAT2 inhibitors like tetrabenazine transform management of movement and neuropsychiatric disorders, signaling a shift toward personalized therapies. by Rosenthal LS, Farag M, Aziz NA and Bang J in Lancet https://t.co/FL5tH1pOwy
#MedX #MedResearch
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The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer. This and more in our latest issue 👉 https://t.co/gucoQ2o03c
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In 2015, just out of medical school, I’d never have imagined seeing my name in @TheLancet. Our review on vesicular monoamine transport (#VMAT) inhibitors is published today. @UCLHD @UCLIoN @UCLBrainScience 🔗 Read the full article here: https://t.co/hMahU1hwe0
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New paper from the @houseofbyrne lab just published in Journal of Neurology: 'Evaluating finger-prick blood collection for remote quantification of neurofilament light (#NfL) in neurological diseases.' A step toward more accessible biomarker testing 🩸
link.springer.com
Journal of Neurology - Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require...
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