UCL Huntington’s Disease Centre
@UCLHD
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Committed to training the next generation of scientists and clinicians to contribute to the fight against Huntington's disease 🧬 @UCLIoN
London
Joined November 2014
We're absolutely delighted to share this exciting news from the @uniQure_NV AMT-130 trial
ucl.ac.uk
A global clinical trial for a new Huntington’s disease treatment has posted positive results today, announced by trial sponsor uniQure and UCL scientists.
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Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
movementdisorders.onlinelibrary.wiley.com
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides...
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Amazing news from @ucl @UCLHD hitting the headlines this week. A new form of gene therapy has successfully treated Huntington's Disease for the first time ever, slowing the disease by 75%. This university research is changing lives. Read more on @BBCNews:
bbc.co.uk
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
We're absolutely delighted to share this exciting news from the @uniQure_NV AMT-130 trial
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Scientists at @UCLHD are leading the way in tackling Huntington's disease – a devastating condition that affects entire families across generations. This breakthrough showcases why the UK remains a global leader in life-changing medical research 🇬🇧🧬
We're absolutely delighted to share this exciting news from the @uniQure_NV AMT-130 trial
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Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @MDJ_Journal on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 Open access link: https://t.co/CepJ9GtLuu
@UCLHD
movementdisorders.onlinelibrary.wiley.com
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides...
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Huge congratulations & thanks to our colleagues @CV_UHB @uniQure_NV @UCLIoN @uclh and to all our incredible HD patients and families - this collective effort over many years has brought us to a landmark step forward.#HuntingtonsDisease #GeneTherapy #UCLResearch #Neuroscience
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"Using #NfL concentrations from capillary blood, we replicated previously published disease group differences measured in venous blood. This data supports our #FingerPrick approach for remote collection and quantification of NfL." J of Neuro https://t.co/acssbe1hqY
@UCLHD @UCLIoN
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New paper from the @houseofbyrne lab just published in Journal of Neurology: 'Evaluating finger-prick blood collection for remote quantification of neurofilament light (#NfL) in neurological diseases.' A step toward more accessible biomarker testing 🩸
link.springer.com
Journal of Neurology - Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require...
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Please see below for study link:
ucl.ac.uk
Explore our clinical research studies in more depth ...
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Thank you to the 79 men in the DIGG-HD study! We need HD gene carrying men to contribute to impactful research on HD gene inheritance from parent to child.
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Brilliant @ThePewterers lecture given by Professor Sarah Tabrizi (@UCLIoN, @UCLHD) on ‘Genetic therapies for neurodegenerative brain disorders - where are we now?’.
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Check out the March 2025 edition of the #HD Clinical Trials Update, now available online in @journal_hd 🔗 https://t.co/mzeqeGqWKj
@UCLHD @UCLBrainScience @UCLIoN
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Hot off the press! Check out the second edition of the @EHDN_GRANTM Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @LeocadiMichela @NickyHobbs321
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Curious about brain imaging in Huntington’s disease? Our latest review in @MDCP_Journal summarises key findings from structural, diffusion and functional MRI, plus emerging techniques like 7T MRI, MEG and novel mHTT PET radioligands currently under investigation.
movementdisorders.onlinelibrary.wiley.com
Background Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by cognitive, neuropsychiatric and motor symptoms caused by a CAG trinucleotide repeat expansion in the...
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A new study led by Prof Sarah Tabrizi (UK DRI at @UCLIoN & @UCLHD) with @GabrielBalmus has taken major steps forward in advancing genetic therapies for Huntington's👏 The research lays an important foundation for future clinical trials👉 https://t.co/uWJBssWS3j
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