Keisuke Kataoka Laboratory（片岡 圭亮 研究室）
@kataoka_lab
Followers
897
Following
2K
Media
9
Statuses
2K
Division of Molecular Oncology, National Cancer Center Research Institute. 国立がん研究センター研究所 分子腫瘍学分野
Joined March 2020
【Paper Published】Our new paper from @kataoka_lab by Kentaro Yamaguchi, @JunjiKoya, and Kota Mizuno et al. has been published in @BloodAdvances. We performed in vivo CRISPR loss-of-function screening targeting 86 genes recurrently altered in DLBCL. ( https://t.co/wiffwgobFG)
ashpublications.org
Key PointsIn vivo CRISPR screening allows efficient evaluation of DLBCL drivers, showing cooperation of Kmt2d/Trp53 losses in B-cell lymphomagenesis.Combin
1
2
23
専門医単位登録 本日の受付17:00まで ※12:10-14:45はclose #血液学会 #JSH87
0
3
11
【重要】第87回学術集会ご参加にあたって ご一読ください。 https://t.co/a8s2e6HAEx
0
5
14
第87回学術集会 参加者の皆様へ オンライン参加登録、コーポレートセミナー参加方法、専門医単位登録など、詳細について、以下、ご案内しております。ご一読ください。 https://t.co/rWuKidL1EJ
0
3
3
腫瘍生物学的に面白い研究。腫瘍細胞の中ではDNAの脱メチル化とメチル化を行ったり来たりする箇所があり、そのfluctuationを利用して腫瘍のたどったクローン進化をバルクで解析した臨床検体でも跡付けることができるという論文。Nature。 https://t.co/VcEc8FOPAS
nature.com
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
1
7
26
Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint @NIDCR_NIH @theNCI @_JackiMays 🇺🇸 https://t.co/yAdLdzh9Yv
0
13
61
【第84回日本癌学会学術総会📚大会紹介📷No.17】 第84回日本癌学会学術総会、シンポジウム「がん医療における大規模臨床ゲノムデータ解析」 座長の片岡圭亮先生（慶應義塾大学医学部血液内科）に、シンポジウムについてコメントを頂きました！是非ご参加ください。 #JCA84 #癌学会 #金沢
1
11
39
がん抑制遺伝子ATMはかなり大きいが、27000個以上の可能な一アミノ酸置換の全てをprime editingで作成、その大半を実験で機能スクリーニング（オラパリブ耐性で判断）、その結果を利用した機械学習で残りの機能も高精度に推定。UKBBとの結果の対応も見ている。CELL誌。 https://t.co/AmMRNo9msv
cell.com
Prime editing combined with machine learning-based evaluation of all 27,513 possible coding single-nucleotide variants and 1,442 intronic variants in ATM provides fresh insights into its elusive...
0
11
76
Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process? In our new @Nature paper now in print, we show WGD continuously shapes tumor evolution and immune evasion. https://t.co/CLrFR2DpNB
nature.com
Nature - A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour...
2
29
81
41症例71検体の卵巣癌の単細胞ゲノム解読（のべ3万細胞）によって、全ゲノム倍加の様々な程度が観察され、対応する単細胞RNA解析から、ニ倍体のみでcGAS~STING活性が観察されるなど、同癌ではゲノム倍加が悪性化と免疫回避につながっているという論文。Nature。 https://t.co/1FZFbjy23n
nature.com
Nature - A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour...
1
4
51
Correspondence: Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy https://t.co/ZrHWa5mPzF
#Hematology #Genetics
1
6
30
The Chan Zuckerberg Initiative has released precomputed TranscriptFormer embeddings for the entire CZ CELL×GENE Census covering 106M human cells and 42M mouse cells, spanning 1000+ cell types in healthy tissue and across hundreds of disease contexts:
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
0
10
37
Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb
nature.com
Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.
7
64
255
Now online! Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
cell.com
SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-C...
0
25
65
B細胞リンパ腫が若いT細胞に顕著で急速な変化を誘導し、老化T細胞に現れる転写、エピジェネティック、老化の特徴を再現すること、つまりB細胞リンパ腫がT細胞と組織の老化を加速させることを示した論文がCancer Cell誌に発表されました。 https://t.co/BdEgeqgDhZ
cell.com
Hesterberg et al. show that lymphoma provokes marked and rapid changes in young T cells that recapitulate the transcriptional, epigenetic, and senescent features manifest in aged T cells, including...
1
11
46