Prof Kamlesh Khunti
@kamleshkhunti
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Professor of Primary Care Diabetes & Vascular Medicine, GP, University of Leicester
University of Leicester, UK
Joined February 2014
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#母の日
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Cardiovascular outcomes for semaglutide similar regardless of baseline metformin use
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So honoured to have recieved my CBE from His Majesty🙏🏻
Never in my wildest dreams did I imagine I would be holding this when I arrived to UK as an immigrant 51 yrs ago
Thank you to each one of you who has contributed to this, esp my family🙏🏻
Miss my parents even more today😢
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3K
Medical student
@ebereillustrate
is transforming medical illustrations using Black patients
We need diversity in our medical textbooks & patient resources
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Acute
#COVID19
associated with
81% ⬆️ diabetes diagnosis
6-fold ⬆️ in cardiovascular diagnoses
11-fold ⬆️ in pulmonary embolism
6-fold ⬆️ in atrial arrhythmias
5-fold ⬆️ in venous thromboses
@fascinatorfun
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747
1K
Geography of
#COVID19
deaths resembles map of childhood deaths in 1850 in England
Key factors include deprivation, over crowding, poor health and working conditions
But these disparities are avoidable
@martinmckee
@Azeem_Majeed
@fascinatorfun
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687
1K
Should those exercising socially distance >2 meters
This study suggests to avoid passing through “droplet clouds” from others exercising these distances should be kept:
Fast walkers at least 4m
Runners 10m
Fast cyclists 20m apart
@trishgreenhalgh
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800
1K
#COVIDVaccination
:
Incredible work by researchers globally.
Within 9 months we have five vaccines with excellent trial evidence & others to come
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Unvaccinated people not only risk their own health but are 'variant factories'
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875
Breaking news
#COVID19
cases in English hospitals jump by 900 in 24 hours!
Are we in denial?
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858
Never in my wildest dreams did I imagine when I arrived as an immigrant to Leicester 50 years ago that I would get a Lifetime Achievement Award from my wonderful City
Thank you
@uniofleicester
@LDC_tweets
& Hockley Farm Practice for giving me the opportunities🙏🏻
@leicslive
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Putting venous blood clots into perspective
Astra-Oxford vaccine risk = 4 people in a million
Women taking combined contraceptive pill risk = 5 to 12 per 10,000 per year
Women not using pill=2 cases per 10,000 per year
@SusanMichie
@chrischirp
@hssood
@NikkiKF
@PHE_uk
@rcgp
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Looking forward to watching
#83
the movie
I was previledged to be on the same flight as the winning Indian cricket team while travelling for my electives to India
And thats me holding the 83 World Cup on the flight with some of the players🙏🏻
@drpratikc
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Humbled & honoured to receive an Honorary Doctorate (Law) from
@dundeeuni
- where i originally graduated from
They were kind enough to give me a break- an inner city lad with very little in terms of academic achievements
Certainly changed my life
Thank you again 🙏🏻
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Well just me & 3 registrars at the practice this week. Others off ill with family or self isolating. Wish me luck🙏🏻
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1348 deaths today
These are really sad statistics
14 days in a row that we have had more than 1000 deaths per day
During the first wave we had more than a 1000 deaths on one day in April
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Largest global study of
#LongCovid
The most frequent symptoms reported after month 6:
Fatigue 78%
Tiredness after exercise 72%
Cognitive dysfunction 55%
They experienced an average of 13.8 symptoms!
@martinmckee
@trishgreenhalgh
@Azeem_Majeed
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Our study of 47,780 people hospitalised post
#COVID19
led by
@DanAyoubkhani
@ONS
At follow-up of only 140 days:
29.4% re-admitted
12.3% died
#longCOVID
Thanks to
@amibanerjee1
@Vnafilyan
@trishgreenhalgh
@martinmckee
@Azeem_Majeed
1/2
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Had
#CovidVaccine
over weekend. Slight ache in arm for 24 hours only & no other issues.
And my staff gave me a sweet for not crying 😂
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After 30 years my Last day as a GP partner at my practice 😢But will be staying on as a salaried doctor doing more sessions than previously to help with the current crisis🙏🏻
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Useful article by
@j_g_allen
on importance of face masks
Homemade masks are 50% efficient
Blue surgical mask 60-80% efficient
For maximal protection use cloth mask over surgical mask 90% efficient
@trishgreenhalgh
@chrischirp
@SusanMichie
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Patients discharged from hospital following
#COVID19
admission at significantly ⬆️ risk for future mortality
50% of people with severe COVID19 died at 12 months
US study
@fascinatorfun
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I am a GP & a cardiomerabolic researcher including covid research.
I & my family have been fully vaccinated including boosters.
This is to protect my patients & my vunerable family members
I also took & Oath to do no harm to my patients🙏🏻
#VaccinesWork
Plz
#GetBoostedNow
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We need to prioritise our values for humanity’s sake🙏🏻
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Message from an esteemed colleague from a top Medical school in India
Sense of sheer helplessness by healthcare workers
#CovidIndia
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One dose of Astra or Pfizer
#CovidVaccine
leads to
50-70% fewer symptoms
75-80% fewer hospitalisations
75-80% fewer deaths
50-60% less likely to transmit
#COVID19
#GetVaccinated
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Some recent good news on transmission with
#COVIDVaccination
75% reduction in asymptomatic cases with Pfizer vaccine
59% reduction with AstraZeneca-Ox vaccine
Please have the vaccine when offered
@chrischirp
@SusanMichie
@parthaskar
@PHE_uk
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Our data show that being fit (Brisk walking) is associated with lower risk of severe
#COVID
ー19
Now that Xmas is over–please try & continue with exercises as well as all other public health measures of facial covering, hand hygiene & social distancing.
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Why elderly need to be prioritised for
#COVIDVaccination
Data showing how many people you need to vaccinate to prevent ONE death:
20 residents in care home
160 over 80's
600 over 70's
2000 over 60's
8000 over 50's
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We in primary care have been asked to delay the 2nd dose of Pfizer-BioNTech
#CovidVaccine
to 12 weeks (instead of 3w) to allow more vaccinations to be delivered to more people
Protection after first dose is 52% but we presume this has been decided on some modelling?
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Good news
Study showing Pfizer/BioNTech vaccine protective against the new UK strain of
#COVID19
👍
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Good news for coffee lovers!
Coffee consumption of up to 3 cups per day associated with better cardiovascular outcomes & mortality.
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Delighted to be awarded
@NIHRresearch
Global Health Research Centre for Multiple Long Term Conditions (Multimorbidity)
Working with
@ARC_EM
#India
and
#Nepal
.
With PHFI, AIIMS Delhi, AIIMS Jodhpur & Kathmandu Medical College
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New paper on
#Longcovid
-common in young people with mild disease as well
At 6 months, 52% non hospitalised people aged 16-30 years had persistent symptoms
#GetVaccinated
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Unfortunately we had a similar situation for a wait for an ambulance at our practice. The child had low oxygen sats and was deteriorating quickly. One of the GPs managed to get the urgency across after a second call
@scelee1
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Real life data show that first dose of Pfizer/BioNTech
#COVIDVaccination
gives 50% protection against
#COVID19
Findings similar to trial evidence
Protection consistent across different ages and comorbidities
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A traditional Hindu Ceremony being conducted in a beautiful Church👏
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For all you curry lovers!
New study
Regular chilli peppers consumption associated with significantly lower risk of all-cause, cardiovascular, and cancer-related mortalities
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Just arrived Canada for a family holiday
We normally visit a place of worship to start the holiday with
What better than Notre-Dame Bailica in Montreal!
Named the 6th most beautiful building in the world
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Some good news for those who have lost the sense of smell as a result of
#COVID19
New study shows 88% of patients completely recover within 2 years.
Mine fortunately only lasted 8 weeks
#LongCovid
@fascinatorfun
@martinmckee
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Just been to supermarket - quite a few people wearing facial coverings but not covering the nose
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Humbled & honoured to recive the
@pcdsociety
Lifetime Achivement Award.
@ClareHambling
presenting the award had me in 😢
Thank you all
@pcdsociety
for your support over years.
Difficult to imagine that we (9 friends) started this in 2005. Gone from strength to strength
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“Quarantino”
Double jabbed but mild symptoms & PCR positive😩🥂
Have a lovely evening🙏🏻
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Systematic Review
Aspirin for primary prevention of cardiovascular disease
Absolute risk of major bleeding with aspirin (with or without statins) exceeds absolute MI benefits for every level of ASCVD risk
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“Call for action” to increase BAME participation in COVID-19 studies. Please share.
@parthaskar
@NIHRresearch
@NikkiKF
@mmamas1973
@trishgreenhalgh
@Azeem_Majeed
@BAPIOUK
@LDC_tweets
@NIHRCRNEastMids
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Treating myself to an Indian breakfast in Mumbai.
Makes a change from the usual porridge with fruits😜
With chai as it should be served👍
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Our Diabetes Management in CKD Consensus Report by
@AmDiabetesAssn
&
@goKDIGO
published
Holistic management strategies - so much evidence base to improve outcomes
Pleasure to have worked with
@P_Rossing
@deboerih
@gbakris
@DiabetesCareADA
et al
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Systematic Review
#LongCovid
Range of heart, lung, gastrointestinal, neurological & psychosocial symptoms.
Commonest are:
breathlessness
fatigue
smell and taste disturbance
anxiety.
Persistent symptoms in hospitalised & non-hospitalised patients
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Lot of discussions on possible risk of clots frm Astra
#CovidVaccine
:
37 events from 17 milion vaccines given
Put it into perspective on clots
1 in 1000 in general population
3 per 1000 by flying
1 per 1000 on combined pill
Vaccine save lives & will help us get to normality
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Review article on Benefits of intermittent
fasting
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After this crisis, remember the NHS is not drained by migrants, but sustained by them. Please please please do remember that👏
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Anyone who thinks covid doesn't affect the young please look at these data & think again
These are deaths registered by age group in England & Wales from around Xmas to 8 January 2021
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Our systematic review of 194 studies
#LongCovid
published
45% of
#COVID19
survivors experience a range of unresolved symptoms at ∼ 4 months.
Thanks to
@OMahoney_L
&
@AshRouten
for driving this
@NIHRresearch
@profhelenward
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Removing masks & physical distancing prior to high vaccination coverage may result ⬆️ in new
#COVID19
cases, hospitalisations & deaths
Simulation study
@fascinatorfun
@martinmckee
@trishgreenhalgh
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Really honoured and humbled to be a one of the recipients of the 2023 Lilly Leonard Award
14yr old Leonard Thompson was the first person with diabetes ever treated with insulin at the University of Toronto in 1922.
#WorldDiabetesDay
#diabetes
#DiabetesAwarenessMonth
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Systematic review of
#Longcovid
45 studies reporting 84 clinical signs or symptoms - Most frequent
Shortness of breath 36%;
Fatigue or exhaustion 40%
Sleep disorders 29%
@trishgreenhalgh
@martinmckee
@Dr2NisreenAlwan
@fascinatorfun
@Azeem_Majeed
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Thank You Thank You Thank You🙏🙏🙏
We have been asking for this since April and at last
Thank you
@adilray
@MeeraSyal
@DavidOlusoga
@Beverleyknight
& colleagues
Commercial TV channels unite to screen Covid vaccine myth-busting video
@trishgreenhalgh
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50% ICU staff report symptoms of post traumatic stress, severe depression,anxiety or problem drinking
Sadly 14% ICU staff report thoughts of self-harm or of wanting to be better off dead
Worse in nursing staff
Need support for
#NHSStaff
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Pfizer
#CovidVaccine
in 12-to-15-year-olds
Good safety profile
Produced a greater immune response than in young adults
Efficacy 100%
UK needs to consider vaccinating children
@fascinatorfun
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Different risk associations of beverages with mortality & cardiovascular disease
⬆️ with sugar sweetened beverages
⬇️ coffee, tea, water & low fat milk
@bmj_latest
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Visualising
#COVID19
transmission routes & mitigations
An informative interactive tool in
@bmj_latest
By
@harryrutter
@CathNoakes
& colleagues 👏
@fascinatorfun
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US Study
27% of survivors of
#COVID19
hospitalisation readmitted or died by 60 days after discharge,
Highest rates of events 10 days after discharge
#LongCovid
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Data from
@UKHSA
Vaccine effectiveness against hospitalisation due to
#Omicron
52% after one dose
72% two doses
88% 2 weeks after a booster dose
#GetBoosted
@fascinatorfun
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Even more important to continue exercise during the pandemic
New study
People who are physically inactive more likely to be admitted with
#COVID19
#PhysicalActivity
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Weight loss is the strongest predictor for T2 diabetes remission - DiRECT Trial
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What a way to encorage physiotherapy for stroke patients!
@parthaskar
@docwas
@AliRacaniere
@ShivaniM_KC
@docwas
@amibanerjee1
@AmarPut
@mmamas1973
@drpatrickholmes
@drpratikc
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30% of people with
#COVID19
report persistent symptoms at 9 months
#LongCovid
Common persistent symptoms
Fatigue 14%
Loss of sense of smell or taste 14%
@amibanerjee1
@martinmckee
@Dr2NisreenAlwan
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The 9
#CovidVaccine
priority groups comprise less than 50% of UK population - BUT make up 99% of the observed COVID deaths.
The top 2 priority groups alone cover two-thirds of the deaths.
Top 4 groups cover 88% of deaths
@martinmckee
@Azeem_Majeed
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Cases of
#Omicron
in UK have nearly doubled in one day after a further 249 cases were confirmed - bringing the total to 817
This is not looking good🙏
@fascinatorfun
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Our article published
@bmj_latest
We should avoid the use of the term "multimorbidity" - it is associated with a negative image
Instead use the term "Multiple Long Term Conditions"
With Harini
@HSathanapally
& Pauline
@pmountainmbe
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A quarter of coronavirus admissions to hospital are people under the age of 55
We therefore need to ramp up vaccinations quickly for all priority groups!
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Bedtime between 10pm & 11pm associated with ⬇️risk of heart attacks & strokes!
Oh dear- i'm on the red line 😢
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Great news from UK Biobank study
99% of people who had tested positive for previous infection retain antibodies to
#COVID19
for 3 months
88% for 6 months
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Just landed in India. Had to start with a dosa for breakfast👌
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Rationale for
#CovidVaccine
priority groups:
Number of people needed to be vaccinated to prevent one death:
20 for care home residents
8000 those aged > 50 years
@martinmckee
@trishgreenhalgh
@Azeem_Majeed
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This is US hospital admissions data with confirmed
#Covid_19
from
@CDCgov
upto 28th Dec
⬆️ in admissions for all ages - see the massive spike in 0-17 year olds
@fascinatorfun
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This is Leicester’s multicultural atmosphere
Bhangra while waiting for the
@LCFC
Bus parade
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Increased rates of respiratory, diabetes & cardiovascular events post
#COVID19
Readmission increased in elderly and non-whites
Urgent need for post discharge follow-up
#LongCOVID
2/2
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Modelling study
Smaller droplets from an infected individual who coughs without a mask could spread well beyond two metres, even when outdoors.
Importance of
#Masks
&
#ventilation
& social distancing
@fascinatorfun
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Humbled & honoured to be this years recipient of Diabetes Philippines Annual Convention Augusto D. Litonjua Endowed Lecture Award🙏
Virtual ceremony😩
Got a medalion!
Do any of the young ones such as
@AmarPut
@parthaskar
@drpratikc
@docwas
want to borrow it for a night out 😂
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Benefits of SGLT2i for the Treatment of Heart Failure Irrespective of Diabetes Diagnosis: A State-of-the-Art Review
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East meets West
Hot cross bun with Indian Chai
Have a great Easter🙏🏻
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And no GPs do not consult like this!
12 hour clinic day yesterday. 40 phone calls in the morning oncall, supervising med students etc, 80% of patients seen face to face in PM. Numerous meetings in between
Our nurses were there for 12 hrs as well
@trishgreenhalgh
@Azeem_Majeed
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Dapagliflozin improves erectile dysfunction in people with T2DM!
Open label non-randomised -Pilot study
SGLT2 inhibitors just keep giving!
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Systematic review of risk factors associated with
#LongCovid
Two
#CovidVaccines
associated with a 43% lower risk of LongCovid
@profhelenward
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Doing a virtual clinic this morning as im
#BAME
& > 55 yrs 😩. Just amazed at how understanding & appreciative patients are. Thank you to all of them🙏🏻
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#COVID19
-19 associated with ⬆️risk at 12 months of many cardiovascular outcomes including strokes, heart disease, pericarditis, myocarditis, heart failure & thrombotic disease.
Including in non-hospitalised patients
#LongCovid
@fascinatorfun
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Morning coffee lovers!
Decaffeinated, ground & instant coffee ( esp 2–3 cups/day associated with ⬇️incidence of cardiovascular disease & mortality.
Ground and instant but not decaffeinated coffee associated with ⬇️ risk of arrhythmia
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Thank you to everyone for your kind messages🙏🏻
And no headaches this morning😊
Cant recall if it was because i was being sensible last night or the good quality plonk🤔
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The new
#COVID19
variant could be present globally
But it was identified in the UK because of the excellent surveillance by UK scientists👏
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Largest study of
#LongCOVID
(Wuhan!)
At 6 mnths following hospital discharge :
76% reported 1 symptom,⬆️ in women
Common symps:
Fatigue or muscle weakness 63%
Sleep difficulties 26%
HAIR LOSS! 22%
Anxiety/depresion a23%
@martinmckee
@trishgreenhalgh
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