Jon Watts
@jwattsgroup
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Oligonucleotide Therapeutics and Chemical Biology. Find us also at @jwattsgroup.bsky.social
Worcester, MA
Joined March 2013
RT @RTI_UMassChan: The RTI & @UMassChan Medical School seeks the next generation of scientific leaders! Join our research community as a Ma….
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Hey, senior PhD students working on RNA and moving toward leading independent labs: Apply for the Maraganore Early Independence Fellow program at @UMassChan @RTI_UMassChan and come work with us!
linkedin.com
I am unbelievably excited and proud to launch the RNA Therapeutic Institute's new Maraganore Early Independence Fellows Program at UMass Chan Medical School. We are looking for exceptional scientists...
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RT @KorostelevLab: Ribosomes unexpectedly moonlight as activators of angiogenin enzyme
nature.com
Nature - The ribosome activates an enzyme that cleaves transfer RNA.
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RT @RTI_UMassChan: So proud of the RTI’s fearless leader Phil Zamore @zamore_lab for receiving the @RNASociety & @CSHL Distinguished Resear….
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RT @UMassChan_BMB: CONGRATULATIONS to our newest PhD, Dr. Adam Hedger, co-mentored by @jwattsgroup and Dr. Celia Schiffer!!!.
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Seems like they missed an opportunity here -- they could have called the combined company the Ornery Renegades. @orna_tx @ReNAgadeTx #RNA.
ReNAgade Therapeutics is acquired by RNA rival Orna Therapeutics a year after launching with $300M. The combined startup will focus on in vivo CAR-T cells and an in vivo gene editing therapy for sickle cell disease. More details in my story for @endpts.
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RT @theNASciences: Congratulations Phillip Zamore of @UMassChan, newly inducted #NASmember! #NAS161 #genetics #medicine .
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Congratulations to the newly minted Dr. @Samantha_Sarli for passing her thesis defense @RTI_UMassChan @UMassChan with a great defense talk.
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RT @Samantha_Sarli: Are oligonucleotides that are chemically optimized for normal brain also active in glioblastoma brain tumors? 👇 @FakihH….
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RT @ArtKrieg: Loving Sudhir Agrawal's cover art for Nucleic Acid Therapeutics, cleverly reflecting the decades of work that have brought ou….
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In the latest paper from senior PhD student @Samantha_Sarli, we compare the activity profile of conjugated and unconjugated ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Amphiphilic lipids help drive safe uptake! Online now at NAR:
academic.oup.com
Abstract. Glioblastoma multiforme is a universally lethal brain tumor that largely resists current surgical and drug interventions. Despite important advan
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RT @UMassChan_BMB: #newscience alert in @naturecomms ! How can you make Nme2Cas9 editing Harder-Better-Faster-Stronger? Check it out! https….
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Watts lab research was selected to compete in STAT Madness again this year! This time the featured research is our collaboration with Joel Richter's lab, building on their key insight that splice-switching ASOs may be therapeutic for Fragile X. Vote here:
statnews.com
Who will be the 2025 MVP of health and medicine? STAT Madness is a bracket-style tournament to find the best innovations in science and medicine from
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RT @UMassChan: Erik Sontheimer, PhD; Jonathan Watts, PhD; and Scot Wolfe, PhD, have received $2.3 million from the Rett Syndrome Research T….
umassmed.edu
Rett syndrome is a rare genetic neurological disorder that occurs primarily in girls, eventually robbing them of the ability to speak, walk or use their hands, among other devastating effects.
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RT @RTI_UMassChan: Read more about it:.UMass Chan studies selected for STAT Madness
umassmed.edu
STAT News has selected three research teams from UMass Chan to compete in its 2024 STAT Madness competition. Members of the public are invited to vote for the best biomedical research from 2023. The...
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Just out: our new genome editing fluorescent reporter mouse is compatible with multiple Cas nucleases and PAM sequences, and reports on both nuclease and prime editing. With @ESontheimerLab and @xue_lab.
"A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors".Chen et al.
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RT @GENBiotechJrnl: Original Research: In Vivo Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Edit….
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So many emotions. On one hand, I'm glad that the publishers of my fifth-grader's math textbook decided that chemistry was the best example of "modeling real life" to put on their cover. But could they not have talked to an actual chemist about the nature of bonding in NaCl first?
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RT @RTI_UMassChan: So many poster awards for our @UMassChanGSBS students at #OTS2023! Congrats, @Samantha_Sarli (@jwattsgroup; 3 yrs in a r….
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