ZamoreLabUMass
@zamore_lab
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Congratulations to Dr. Arif for a successful thesis defense today!
biorxiv.org
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins can be found in all kingdoms of life, and play diverse biological functions...
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RT @IGainetdinov: Congratulations, Dr. Yongjin Lee! Great job!.Your artistically unique view of your favorite model organism is amazing. ht….
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RT @KorostelevLab: How do Dicer-1 and Loqs-PB make miRNA?. We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loq….
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RT @AlexeiAravin: @peiwei_chen and I were happy to contribute to this remarkable work from @yamashitaflylab and @zamore_lab. I am fond of….
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RT @sRNAPapers: Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons.ht….
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RT @IGainetdinov: Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons. Our data overturn the c….
biorxiv.org
In animals, piRNAs direct PIWI-clade Argonaute proteins to slice complementary transposon transcripts. Transposons can evade silencing through target site mutations. We report that PIWIs efficiently...
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New manuscript from Zamore lab explains the biological advantage of PIWI proteins and piRNAs over AGOs as defense against transposons.
Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons. Our data overturn the common presumption that AGO and PIWI Argonautes follow similar rules for identifying their RNA targets.
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RT @peihsuanwu1: The Wu lab is looking for motivated PhD students to study the paternal effects of #smallRNA in embryo development at the F….
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RT @EMakeyev: Very happy to start this account with a great news - our new proximity biotinylation technology for genetically unmodified ce….
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RT @IGainetdinov: In the animal germline, piRNAs silence transposons and regulate host genes. Without piRNAs, animals are sterile. If you w….
cell.com
piRNAs are an animal-specific class of small RNAs that repress transposons and regulate genes. piRNA biogenesis concludes with 3′ terminal trimming and 2′-O-methylation. Gainetdinov et al. show that...
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RT @UMassChan: Chancellor Michael F. Collins says a $175 million gift from the Morningside Foundation will permit UMass Chan Medical School….
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RT @eDougBanks: Unlocked and open to all readers: .UMass Medical School will be renamed following a $175M donation from the Chan family's….
bizjournals.com
The University of Massachusetts Medical School will be renamed following a $175 million donation from The Morningside Foundation — a gift that will more than double the endowment of the state’s only...
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RT @UMassChan: With gratitude for the transformational philanthropy of the Morningside Foundation, UMass Medical School is now UMass Chan M….
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RT @UMassChan: 📢 LIVESTREAM ALERT: Go to at 10 a.m. to watch a news conference on UMass Medical School's new name….
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Thanks to Acorn Innovation program for award funding critical experiments to de-risk our miRNA technology!.
We're pleased to announce today $195,000 in #SeedFund awards to 13 MA faculty researchers through our Acorn Innovation program! Research addresses #breastcancer #kidneydisease, #foodwaste, #pfas #lithiumionbatteries and more. Read about the awardees here:
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RT @massventures: We're pleased to announce today $195,000 in #SeedFund awards to 13 MA faculty researchers through our Acorn Innovation pr….
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Hi everyone! The Zamore lab is looking to hire a new lab manager. If you know of anyone who might be interested, please send them my way. Our posting can be found here:
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There are only 18 days left to register for the 2021 RNA Therapeutics Symposium. Information on how to register and awards we have available can be found here: #RNATx2021.
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We are hiring for multiple positions: Postdoctoral Researchers, an Executive Assistant to the Chair, and a Research Laboratory Technician. Information on how and where to apply can be found on our lab website:
zamorelab.umassmed.edu
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Study on the function of mouse pachytene piRNAs from Dean Lab: Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA
biorxiv.org
piRNAs are germline-specific, small non-coding RNAs required to maintain genome integrity and preserve RNA homeostasis during male gametogenesis. In murine adult testes, the highest levels of piRNAs...
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