SchaferLabUMassChan
@SchaferLabUMass
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Laboratory of Dori Schafer
Worcester, MA
Joined December 2019
My apologies for the delay in posting. A terrific effort from @jacobmstillman and @KiniwaT1023 in the lab. A review on nucleic acid sensing in the brain.
onlinelibrary.wiley.com
Nucleic acids are a critical trigger for the innate immune response to infection, wherein pathogen-derived RNA and DNA are sensed by nucleic acid sensing receptors. This subsequently drives the...
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An exciting neural immune keystone this June! Run jointly with neurodegeneration keystone. Sign up soon.
keystonesymposia.org
Join us at the Keystone Symposia on Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology, June 2025, in Whistler, with field leaders!
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Amazing mentors are key to success. @MattRasband is one of the very best!.
I am mostly silent on Twitter. But today I must post something: I met with three amazing and incredible women scientists I had the privilege of mentoring as PhD students in my lab. Dori Schafer, Shelly Buffington, and Tammy Ho. They helped make me who I am.
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RT @UMassChan: UMass Chan Medical School will host a news conference with Victor R. Ambros, PhD, who shares the 2024 @NobelPrize in Physiol….
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RT @jkagan1: Everything you wanted to know about the Big Three DNA Sensors: AIM2, cGAS, TLR9. Several suppritive characters also discussed….
nature.com
Nature Immunology - In this Review, Fitzgerald and Dong summarize the fundamentals of DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.
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RT @stevens1lab: Hope to see many of you in Chicago -stop by the Glia & Neuroimmune Social Monday pm!.
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Such an amazing meeting. Thank you to this phenomenal staff as well as @jonykipnis and @IdoAmitLab. Amazing.
The real heroines behind #ReThinkNeuroimmunology 👏👏👏.No words can sufficiently express my gratitude 🙏
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Thanks to all the support from @UMassChan @NeurobioUMass. It is a honor to be part of this community.
#ICYMI: @UMassChan has 12 new endowed chairs, including five @umassmemorial Health chairs: @ambarrett @UMassChanNeuro @UMassRadiology @UMassMedicine @PRCUMassChan @ollie_rando @UMassChan_BMB @SchaferLabUMass @NeurobioUMass @Pthompsn1018 #fbf.
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To senior grad students and junior postdocs. Umass Chan early independence fellows program. An opportunity @UMassChan to develop your independent research program. An outstanding and supportive environment to grow and excel.
umassmed.edu
UMass Chan Early Independence Fellows Program
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Thanks to @LiddelowSA!! An excellent #cshlglia partner in crime. @cshlmeetings are truly the best to work with and make it all possible. Thank you to the glia community for the excellent talks , scientific exchange, and engagement.
That's a wrap for #CSHLGlia @cshlmeetings. Thanks to everyone for making it the most amazing meeting, and to @SchaferLabUMass for being an excellent chair. See you all again in 2026!
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Yay @SamaraVilca !!!.
Posdoctoral fellow Samara Vilca, PhD, has received an NIH D-SPAN award to study how brain cells respond to substance abuse: The @NIH award supports outstanding graduate students who are from diverse backgrounds. @SamaraVilca @wickedneuro @SchaferLabUMass.
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RT @cshlmeetings: Welcome to all of our Glia in Health & Disease participants! Make sure to use #cshlglia for all your posts 🦠. A special t….
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One week away and counting #glia community @cshlmeetings. @LiddelowSA and I are excited to see everyone!.
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PhD candidate Jacob Stillman has won a @NIH_NINDS-funded Ruth L. Kirschstein Award to further his research on remyelination. Discover how he’s working to target diseases such as multiple sclerosis: 🧬 🧠 . @jacobmstillman @SchaferLabUMass @NeurobioUMass.
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As much as I love microglia and they play clear roles in the removal of synapses in multiple contexts, they are not the sole driver of synapse remodeling. Lots of neuron intrinsic mechanisms and other glia are involved too. Very important to recognize.
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I wanted to further echo @eyolab enthusiasm for this work that is nicely complementary to @stevens1lab work that C1q does not regulate OD plasticity in the same brain region. Both studies here: .
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Thanks for doing south am amazing job leading this course @lab_schaefer and @AlixBattison. I feel very lucky to be a small part of this special group of people @CSHL.
@AlixBattison @tollkuhn @brunogegenhuber Thank you to an amazing group of students TA’s instructors and faculty willing to spend the holidays together doing science at @ATMN24 at @CSHL ! @AlixBattison .@tollkuhn @lab_schaefer @PaulKennyPhD @brunogegenhuber @SchaferLabUMass
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Announcing the next joint neural-immune and neurodegeneration keystone symposia @KeystoneSymp. Join me and other neural immune organizers Anne Schaefer @lab_schaefer and Asya Rolls @rolls_asya in beautiful Whistler, BC June 4-7 2025.
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Happy to share our lab’s recent review in Current Opinion Neurobiology on “Microglial phagocytic mechanisms: Development informing disease”. Special Thanks to @becca_beiter and @patwsheehan in the lab @NeurobioUMass for their hard work on this piece:.
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Very important work from @patwsheehan @ErikMusiek Time of day matters for glia. It has made some confusing data in our lab much less confusing now. This is super important for the field.
Finally, we made a website so that anyone can query their gene of interest to see if it is rhythmically expressed in bulk tissue, astros or microglia. We also include aggregated plots so you can tell if your gene is upregulated in APP or normal aging.
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