Jorg Morf
@jorgmorf
Followers
190
Following
1K
Media
1
Statuses
454
Joined April 2018
Selective RNA sequestration in biomolecular condensates directs cell fate transitions | Nature Biotechnology
nature.com
Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.
0
0
0
Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity https://t.co/LeXnsRNbEc
#biorxiv_genomic
biorxiv.org
Growing evidence indicates that transcriptional regulatory elements can exert both promoter and enhancer activity; however, the relationship and determinants of this dual functionality remain poorly...
0
5
32
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation. https://t.co/iuBeiP6b5H
2
2
27
Read the @scTrends_update take on the AI arms race to generate single-cell data https://t.co/2GfiRhwzEW Thanks @AdamCribbs !
sctrends.org
AI-scale data generation, new tech, latest News and M&A.
0
6
10
Our latest @scTrends_update article is now in @CellGenomics: https://t.co/HRaUAjqXbP Paired with this is our end of year round up: https://t.co/faq6ASYyCY Get in touch if you want to be involved!
1
10
15
Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] https://t.co/4AhPJf9jR9 ▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP) ▶️Connectivity of nucleosomes in S. cerevisiae ▶️Chromatin is predominantly organized in regular nucleosome arrays
0
17
79
Thrilled to share our latest manuscript on smOOPs, a highly interconnected class of condensation-prone mRNAs with signs of coordinated regulation, encoding functionally related proteins. Shoutout to the incredible team @IraIosub, Jona & @KlobucarTajda.
biorxiv.org
In the crowded cellular environment, the transcriptome is highly organised with a network of interactions between proteins and RNA molecules that are crucial for the formation of biomolecular...
4
13
45
Happy to share that our new preprint is now live! Read below to learn about our technology for imaging-free spatial genomics!
We developed an imaging-free spatial genomics technology where DNA barcodes diffuse to connect locally. Using UMAP, we reconstructed the physical locations of these barcodes, transforming spatial transcriptomics into purely molecular biology. https://t.co/BIPlyibPXa
2
15
83
A bit of advertising for our review. Please take a look - we definitely spent a lot of time on this and dipped our toes well outside our comfort zone! Orchestrated centers for the production of proteins or “translation factories” - WIREs RNA
wires.onlinelibrary.wiley.com
Translation factories: the hows and whys.
3
22
83
A community effort to track commercial single-cell and spatial ’omic technologies and business trends https://t.co/suvfo1IJ8m
2
21
76
Today is the go live day for @scTrends_update! A consortium to both review *commercial* technologies, but also study market trends to assess angles for how technologies may differentiate themselves.
Have you ever wondered which single cell/spatial omic technology to use? There's lots of methods developed in academia, but no review of marketed products. Check the @scTrends_update ( https://t.co/aEMejm8Upm) commentary in @NatureBiotech by @wildtypehuman & @AdamCribbs
2
8
29
Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long? Our latest research in @NatureCellBio reveals that oocyte maintenance involves exceptional protein longevity. https://t.co/ZiByc9F4hS (1/9)
18
285
1K
What if we used sedimentation to look at RNAs instead of proteins? Behold: @ewjwallace created Sed-seq! And Sed-seq immediately revealed a bunch of surprises. First, whereas a small set of proteins (~15%) condense during stress, nearly all RNAs condense. 6/n
2
11
49
How do cells efficiently respond to stress? Transcriptional stress responses are well-known—and in our latest study, we discover that cells use biomolecular condensation to redirect translation from old to new mRNAs 1/n
biorxiv.org
Stress-induced condensation of mRNA and proteins into stress granules is conserved across eukaryotes, yet the function, formation mechanisms, and relation to well-studied conserved transcriptional...
10
78
295
Finally out! We found that mRNAs are not uniformly distributed across the cytoplasm. mRNA architecture is the strongest determinant for localization. Subcytoplasmic location of translation controls protein output. https://t.co/CJW80etwG7
cell.com
Horste et al. find that mRNA transcripts that encode non-membrane proteins are not evenly distributed across the cytoplasm. Instead, functionally related groups of transcripts are enriched in...
22
296
1K
Very sad news that Takao Kondo, a great scientist and pioneer of the Cyanobacterial clock system has passed away. RIP. @SRBR_Outreach 訃報 近藤孝男先生（本会名誉会員）がご逝去されました | 日本時間生物学会
chronobiology.jp
2023年11月16日名古屋大学の近藤孝男特別教授がご逝去されました。謹んでお知らせ申し上げます。近藤先生は、シアノバクテリアの概日リズムに関する研究で顕著な業績を残されました。先生は自ら開発した機器を用いて、その基本的な分子機構を明らかにし、単純な分子（時計タンパク質、KaiA, KaiB, KaiC）を混合することで、生物時計の試験管内再構成を世界で初めて成し遂げました。また、教育者とし...
0
4
18
The first (?) report on the contributions of repeat expansions to Alzheimer's risk. Individuals with a genome-wide burden of STRs with >30 repeat lengths have an OR of 3.63, with a severe degree of brain pathology. Fascinating! Guo, Cremins et al. medRxiv https://t.co/QcrKkQXBf7
3
39
154
Finally after many years of work it's out... my magnum opus! We found that the #CircadianClock in articular cartilage and intervertebral discs is synchronised by exercise through combination of mechano and osmo sensitivity of chondrocytes. https://t.co/gwl9fhDKKC
15
49
193
Can random genes do good? How are genes born? A ground breaking work by Idan Frumkin and @michael_laub8 provide an amazing insight and detailed experimental dissection - random gene birth, whose encoded protein work with cell machineries, is very feasible https://t.co/GBdWPF2ZAR
0
81
213
New preprint! We (@xiuzhenchen) found a new mRNP network that covers the whole cytoplasm. We call it the FXR1 network, as it is formed through packaging of exceptionally long mRNAs by FXR1.
2
34
144