Yifat Merbl lab
@YMerbl
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Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology
Weizmann Institue of Science
Joined August 2018
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology.🔗 .🧵👇.
nature.com
Nature - Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics...
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Thank you for this amazing highlight of our work 🙏🙏🙏.
Top 5 advances in medicine this week (🧵). 1. An untapped treasure trove of antibiotics . The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics. The top hit is a peptide derived from a
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RT @LabWaggoner: Protein waste turned into antibiotics in the proteasome as a innate defense strategy of human cells .@Nature @WeizmannScie….
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A big thank you to Tim Clausen (@clausen_lab) for writing such a thoughtful N&V about our recent paper!.
nature.com
Nature - Proteasome cleavage changes during infection to generate antibiotics.
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Thank you for the shout-out 🙏 and for the @ERC_Research's ongoing support! @WeizmannScience.
🆕 way to fight resistant superbugs? 🦠.ERC grantee @YMerbl and team @WeizmannScience revealed a secret defence in the immune system - reshaping our understanding of infection protection. 👉 👉 @Sys_Immunology #Immunology
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5/ This discovery was led by the incredible @KarinGoldberg5 and the amazing support of other team members - highlighting the meaning of teamwork. A huge shoutout to our fantastic collaborators Gee W. Lau, Nissan Yissachar, and Zvi Hayouka.
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4/ We hope these findings contribute to a better understanding of innate immunity, and open up exciting possibilities for developing new therapeutic strategies against infections, particularly in the face of rising antibiotic resistance.🔬✨.
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3/ Using in silico prediction, we identified hundreds of thousands of potential proteasome-derived defense peptides (PDDPs)—an untapped reservoir of natural antimicrobials.
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2/ Infection triggers shifts in proteasome composition & function, enhancing its antimicrobial activity. This suggests a built-in defense mechanism beyond adaptive immunity.
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1/ For decades, proteasome-derived peptides were mainly linked to antigen presentation. But we found they also act as innate immune effectors—produced both constitutively & in response to infection.
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RT @Elinav_Lab: 1/14 Excited to share our new @Elinav_Lab @Elinav_DKFZ @WeizmannScience paper @CellCellPress, championed (for 6 years!) by….
cell.com
A metagenome-informed metaproteomics approach unravels the interplay between the host, gut microbiome, and diet in animal models as well as in human cohorts and identifies disease biomarkers of...
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RT @Paola632898361: Fascinating talk by Andrea Murachelli who defined a structure of BRCA1-A with a novel metallo-DUB Inhibitor #EMBOubiqui….
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RT @Paola632898361: We started the last session on UPS therapeutics with a great talk by Stefan Müller @IBC2_GU on SUMO-UB network in stres….
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RT @Paola632898361: Great talk by Wilhelm Vaysse-Zinkhöfer regarding CUL5WSB2 and how it regulates degradation in neuroblastoma #EMBOubiqui….
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