Yifat Merbl lab
@YMerbl
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Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology
Weizmann Institue of Science
Joined August 2018
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology 🔗 https://t.co/YzgdM8gsON 🧵👇
nature.com
Nature - Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics...
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Let’s not just hope — let’s act — for a future of peace and dignity for all. Violence and hatred must end. Humanity must lead, and science must light the way. 🙏💫🙏
nature.com
Nature - Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
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@YMerbl You are welcome, your paper is completely fascinating
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Thank you for this amazing highlight of our work 🙏🙏🙏
Top 5 advances in medicine this week (🧵) 1. An untapped treasure trove of antibiotics The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics The top hit is a peptide derived from a
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Protein waste turned into antibiotics in the proteasome as a innate defense strategy of human cells @Nature @WeizmannScience @KarinGoldberg5 @YMerbl
https://t.co/O7C6d7qRbb
@NatureNV by @clausen_lab
https://t.co/6rKshHvh7T
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A big thank you to Tim Clausen (@clausen_lab) for writing such a thoughtful N&V about our recent paper! https://t.co/mlTwZZPjPw
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Thank you for the shout-out 🙏 and for the @ERC_Research's ongoing support! @WeizmannScience
🆕 way to fight resistant superbugs? 🦠 ERC grantee @YMerbl and team @WeizmannScience revealed a secret defence in the immune system - reshaping our understanding of infection protection. 👉 https://t.co/WU17lUq8dY 👉 https://t.co/V2oveZHBwE
@Sys_Immunology #Immunology
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Excited to see our work covered @BBCNews. Thank you @JamesTGallagher for covering it 🙏🙏🙏 https://t.co/NlJgGGh22W
bbc.com
New part of the immune system - hidden inside our bodies - could be used to make new antibiotics.
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5/ This discovery was led by the incredible @KarinGoldberg5 and the amazing support of other team members - highlighting the meaning of teamwork. A huge shoutout to our fantastic collaborators Gee W. Lau, Nissan Yissachar, and Zvi Hayouka.
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4/ We hope these findings contribute to a better understanding of innate immunity, and open up exciting possibilities for developing new therapeutic strategies against infections, particularly in the face of rising antibiotic resistance.🔬✨
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3/ Using in silico prediction, we identified hundreds of thousands of potential proteasome-derived defense peptides (PDDPs)—an untapped reservoir of natural antimicrobials.
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2/ Infection triggers shifts in proteasome composition & function, enhancing its antimicrobial activity. This suggests a built-in defense mechanism beyond adaptive immunity.
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1/ For decades, proteasome-derived peptides were mainly linked to antigen presentation. But we found they also act as innate immune effectors—produced both constitutively & in response to infection.
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1/14 Excited to share our new @Elinav_Lab @Elinav_DKFZ @WeizmannScience paper @CellCellPress, championed (for 6 years!) by the amazing @rvaldesmas, @AvnerLeshem, @DanpingZheng and twitter-less Alon Savidor. In this work, we’ve adopted into microbiome..
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Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from @werner_achim Kai Gallant from @MalteGersch and Chatrin Chatrin from @IvanAhelLab Well done! 👏💫🏆 @YKulathu @polosimona1 @LabJoazeiro
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it’s a wrap- thank you all 🙏 Such high energies following a meeting with great science, amazing people and beautiful views 🤩🥂💃🕺💫#EMBOubiquitin24
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Fascinating talk by Andrea Murachelli who defined a structure of BRCA1-A with a novel metallo-DUB Inhibitor #EMBOubiquitin24
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We started the last session on UPS therapeutics with a great talk by Stefan Müller @IBC2_GU on SUMO-UB network in stress mediated aggregation #EMBOubiquitin24
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Great talk by Wilhelm Vaysse-Zinkhöfer regarding CUL5WSB2 and how it regulates degradation in neuroblastoma #EMBOubiquitin24
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