
Jeffrey Iliff
@Jeffreyiliff
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neuroscientist studying glial-vascular processes underlying neurodegenerative disease; view are my own.
Seattle, WA
Joined October 2014
RT @ScienceMagazine: In a new #ScienceReview, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alz….
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Our review, led by @SamanthaKeilPhD , providing a critical and up-to-date assessment of the role that glymphatic dysfunction plays in the development of clinical Alzheimer's disease, was published in @ScienceMagazine today:
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Our new paper with Applied Cognition in @natBME . Using a wearable device that captures different determinants of glymphatic activity to define sleep-related features of glymphatic function in the human brain.
nature.com
Nature Biomedical Engineering - A wearable device measures parenchymal resistance and its dynamic relationship with sleep MRI measures of glymphatic function, EEG features and cardiovascular...
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A lovely visit to @OxfordDPAG and @KavliOxford - so many thanks for the questions, conversations and hospitality!
It was an absolute delight to host @Jeffreyiliff to @OxfordDPAG and @KavliOxford . He delivered a fantastic talk about “Glymphatic dysfunction as a driver of Alzheimer’s disease: Moving past the hype”. Thoroughly enjoyed his accompany along with the amazing @RoslynBill
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Many thanks to colleagues in the @UKGlia for letting me join you this past week in Sheffield. It is an exciting community, and great fun to be a part of it for a bit. Congratulations on a fantastic inaugural meeting!.
Kick off of our first UK Glia meeting with great attendance and an even greater keynote by @Jeffreyiliff #UKGlia
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An exciting day in Birmingham. Congratulations to @AstonAIME, and especially collabotor-extraordinaire @RoslynBill , for the start of this new Center. Thanks for letting me be a part of the day!.
🙌 An incredible launch event today! Thank you to all the speakers and delegates who joined us to celebrate this milestone. We look forward to an exciting future ahead. View the highlights of the day below ⬇️
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RT @ScienceMagazine: A new Science study in mice identifies a novel non-synaptic signaling mechanism between the brain and peripheral senso….
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A second new preprint, from a collaboration with Applied Cognition. Evidence from human participants that sleep-active glymphatic function contributes to the clearance of amyloid beta and tau from the brain to the plasma:.
medrxiv.org
Poor sleep is implicated in the development of Alzheimer’s disease (AD) pathology and cognitive impairment. The glymphatic system has been proposed as a link between sleep disruption and AD, and in...
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Two new pre-prints in the glymphatics space. A combined human neuropath and rodent study defining the linkage between glymphatic dysfunction, alpha synuclein pathology, and Lewy body dementia:.
biorxiv.org
The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Sleep disruption is...
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This is a really nice summary of a wild 12 years in the CNS barriers field. Very accessible to a lay audience - a good piece to recommend to the interested non-nerds in your life. The anatomy of brainwashing | Science
science.org
Glymphatic-lymphatic brain cleansing may reveal new therapeutic strategies
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Something new, just out in @_JCBFM : Evaluating two different contrast-free MRI measures of cranial fluid dynamics in sleep deprived and aged human participants. Subarachnoid fluid transport, and glial-vascular water exchange.
journals.sagepub.com
We discuss two potential non-invasive MRI methods to study phenomena related to subarachnoid cerebrospinal fluid (CSF) motion and perivascular fluid transport, ...
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RT @SamanthaKeilPhD: I had the unique privilege of presenting work from both my @Jeffreyiliff lab translational postdoc work in sleep and n….
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RT @Iben_Lundgaard: DAY 1 at Lund Glymphatic Symposium! #LGS2024 with @Jeffreyiliff @PK_Eide What an amazing start!
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RT @RoslynBill: We meet in person at last. And it was worth the wait!. @Jeffreyiliff @MootazSalman @ERC_Research #FORTIFY #AQP4
https://t.….
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Here is an RFI from the @NIH National Commission on Lymphatic Diseases seeking input into knowledge gaps and opportunities related to LDs:.Researchers engaged in meningeal lymphatic and glymphatic research represent a new frontier for this field. Chime in!.
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The @NIH has established a National Comission on Lymphatic Diseases focused on increasing understanding of lymphatic disorders. Now is the time for folks studying lymphatic function in neurological and psychiatric disorders.
nhlbi.nih.gov
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RT @LGDAlliance: Your insights are crucial! Join the NIH’s National Commission on Lymphatic Diseases in the future of lymphatic research &….
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RT @uwmnewsroom: Changes in the brain's system for clearing waste & neurotoxins might explain higher risk of psychiatric disorders & cognit….
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RT @SamanthaKeilPhD: Excited to share our new @Jeffreyiliff lab work, “Macroscopic changes in aquaporin-4 underlie blast traumatic brain in….
academic.oup.com
Blast traumatic brain injury is associated with an increased risk of long-term neurological and psychiatric sequelae, but the underlying mechanisms are unc
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A potential explanation for our recent finding that in Veterans with a history of blast TBI show reduced CSF levels of Alzheimer's biomarkers, including Abeta.
neurology.org
Background and ObjectivesModerate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar...
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