Jaime de Juan-Sanz
@JaimedeJuan
Followers
3K
Following
6K
Media
517
Statuses
4K
Team Leader @ParisBrainInst. Synapses and metabolism 🔬🔬🔬 Funded by @ERC_Research. @FENSKavliNet scholar. @CNRS researcher
Paris, France
Joined November 2011
The largest medical #AI randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening, was published today @LancetDigitalH The use of A.I. led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared
thelancet.com
The findings suggest that AI contributes to the early detection of clinically relevant breast cancer and reduces screen-reading workload without increasing false positives.
99
923
4K
Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for
3
93
416
Almost all neurons co-release peptides and small transmitters. Thrilled to share our latest research where new GRAB sensor promotes better understanding of the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. https://t.co/P7XPjjP46y
5
63
274
We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API
24
250
864
An #AI model created to design proteins simulates 500 million years of protein evolution in developing a previously unknown bright fluorescent protein. Learn more in a new Science study: https://t.co/klcE9wFRco
19
242
654
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: https://t.co/t7zqOdKvFt
@CellCellPress
10
104
442
Every Jan 13, World Depression Day invites us to reflect on one prevalent and severe mental health problem. In @PROMPT_depress ( https://t.co/0l1HboPkgu) our innovative research aims to help people with depression! Please support us by answering the survey!
0
5
8
this conversation will be on replay for many academics this Thanksgiving.
19
199
1K
1/10 Delighted that our study using pharmacogenomics to find compounds promoting oligodendrogenesis and repair in myelin pathologies is now published in Nat Communs, after 7 years of work! https://t.co/kaf1MTlukO (DOI: 10.1038/s41467-024-54003-9)
6
7
23
Sadly, this @NeuroCellPress review on animal models of individuality fails to reference any work in worms and flies, despite pioneering work demonstrating causal links between genes, brains and behavioral individuality was done in these models.
cell.com
Hille et al. wish to strengthen connections between human research and animal models of brain plasticity. They propose to make greater use of macroscopic imaging methods in animals, intensify...
8
20
71
🧠⚡️📄Excited to finally see this piece of work published!! Lots of effort and fun through this story of endogenous protein trafficking during activity. Who will be labeled next? 😉
Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology
https://t.co/1PG9APWTWM
2
6
18
Como cada cual ayuda como puede, somos un grupo de Profesores de Universidad de historia del arte y ofrecemos visitas gratuitas al Madrid de los Austrias a cambio de donaciones para la DANA. Os dejamos el comunicado y el link: https://t.co/D5N5Wlpeqx
18
730
1K
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes! https://t.co/RmGRnut5my 🧵1/11
4
46
179
Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology
https://t.co/1PG9APWTWM
1
4
7
⚡️⚡️Paper alert! Very proud of the fantastic work of @CarlitosRoca7 in my lab, who single-handedly has developed a new way to quantify trafficking of endogenous proteins in synapses!
Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology
https://t.co/1PG9APWTWM
8
12
64
Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology
https://t.co/1PG9APWTWM
0
3
13
Trump is literally Hitler, but we put the Hitler quotes in Comic Sans to make it funny
1K
8K
26K
We are closing out #NationalChemistryWeek – and celebrating #FluorescenceFriday -- with one of the newest biosensors developed @HHMIJanelia: WHaloCaMP – the first demonstration of a new strategy for making fluorescent biosensors for imaging physiology. 🔗 https://t.co/oVKLIGn0Hn
0
64
239