Fergus O'Farrell
@fergusofarrell
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Doctor (Histopathology Trainee) & Neuroscience postdoc. Neuropathology. PhD via @UCL_MBPhD. Neuron-glial-vascular interactions, physiology. 🌿📚🏳️🌈 he/him
Cambridge / London
Joined December 2008
Brain capillary in an acute cortical slice. Imaged by me 6 years ago today (according to my phone).
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Jean-Martin Charcot was born in Paris on 29 November 1825. @ajlees marks the bicentenary of Charcot's birth by reflecting on how his scientific legacy continues to shape neurology today. https://t.co/ExO6Vy9Hny
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Papers like this which demonstrate that alpha synuclein can act potently as prions, are exactly why you need to have proportionate safety measures in labs doing this kind of work. If you work on this and don’t have safety measures ask why! Great paper btw.
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Lymphoid gene expression supports neuroprotective microglia function https://t.co/80mqNcqitO
nature.com
Nature - PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating...
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Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT https://t.co/MxaGj7kqNp
nature.com
Nature - Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine...
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Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease @NatureNeuro
https://t.co/Poy7fNXGDp
nature.com
Nature Neuroscience - Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to...
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Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human https://t.co/bBbIaM2n6r
nature.com
Nature Communications - Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and...
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Thrilled see our paper out in @Nature ! 🤩 Wonderful collaboration with @GoCasteloBranco. Kudos to my amazing postdoc @Di_0579 at @YaleEngineering and Leslie Kirby from Goncalo's lab @karolinskainst. Huge team science with @YaleMed @UCSF @ASTARsg
https://t.co/IF7XbnS1q0
nature.com
Nature - A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
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Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. https://t.co/0YtGTd4Dwb
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Online now: The brain neurovascular epigenome and its association with dementia
cell.com
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and...
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The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease
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Today, I teach the (graduate) kids about long-term memory. I'm bringing along my 3D print of HM's brain, made from post-mortem histology. #neuroscience
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The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation | Science Advances
science.org
CLIC1 regulates surveillance, morphology, and interleukin release in mouse and human brain microglia.
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Excited to share our @CurrentBiology Primer written with @AudreyChagnot in the Brain-Body Interactions special issue! We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health. @UKDRI @TheBHF
https://t.co/QnwkVuHEWh
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An amazing collection of brain-body interaction articles in this special issue. Love the beautiful vagus nerve on the cover by Andreas Vesalius https://t.co/K1El0JuJDX
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Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape @EinsteinMed @montefiorenyc @karolinska @Einstein_SCI
https://t.co/TjLM6HDTfJ
nature.com
Nature Neuroscience - Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and...
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Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning @BaolingL
https://t.co/kMbQT5rufe
nature.com
Nature Neuroscience - Lai et al. show a function of astrocytic Ca2+ in preventing synaptic depotentiation by reducing repetitive dendritic activity in the motor cortex during motor training,...
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Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 | Nature
nature.com
Nature - Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic...
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As the 2025 competition ratios come out I have no doubt we will see people stating what a huge success this is for psychiatry or that this is the result of the ChoosePsychiatry campaign I’ve shared my views previously why this is not the case - we need reform of recruitment
Core psychiatry training has gone from a fill rate of only 67.3% in 2017 to a competition ratio of around 20 applicants per post this year While this superficially might appear to be a good thing it actually highlights significant problems that need to be addressed 1/?
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Specialty training competition ratios for 2025 released. An awful day to be a doctor out of training or a medical student. Frozen progression is a further nail in the coffin of a career in medicine in the UK. https://t.co/gJAwr98zeQ
medical.hee.nhs.uk
Competition ratios for the 2025 recruitment round
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A gracious review in @PracticalNeuro from the Cardiff Book Club. Ideal for those with a discerning but short attention span and hand luggage and costs less than a Burger King meal Press the button now https://t.co/DmVBHNUr7J
@MirabeauPress
https://t.co/ae0drdtzvA
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