DNA Binding Lab Structure Collection https://t.co/IcGFtStvKf (Using Current Biology protein databases) #structure #mol #MOLECULE #iOS #structuralBiology #DNA #science #simulation #lab

Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.

Wrapping up another year of groundbreaking AI research and innovation. We're deeply grateful to our incredible community of researchers, industry partners, and collaborators who continue to push the boundaries of what's possible. Thank you for making 2025 extraordinary. We'll

🧬 CRISPR 2.0–engineered T cell therapies. Base and prime editing enable precise, programmable genome modification in T cells, reducing unwanted edits seen with CRISPR Cas9. These platforms aim to enhance T cell fitness, expand targetable antigens, and simplify manufacturing,

Gemini 3 Deep Think is here. Deep Think is our most advanced reasoning mode that explores multiple hypotheses simultaneously to give you an even more sophisticated output.

Atom-level enzyme design with RFdiffusion2 Designing new enzymes usually starts from an “ideal” active site—key functional groups arranged around a transition state—and then tries to find or tweak a protein scaffold that can hold that geometry. Existing AI methods can help, but

Reading books 30+ minutes a day was linked to a 20% lower mortality over 12 years The survival benefit was significantly stronger for books than newspapers/magazines (and appeared to be mediated by cognitive engagement)

Should we continue anticoagulation indefinitely after catheter ablation of atrial fibrillation? https://t.co/FAK9N28AF4 @NEJM #CardioTwitter

four strange attractors and their formulas

miRNA have multiple functions beyond their role in modulating translation.

5 science breakthroughs this week (🧵) 1. One treatment, many cures Genetic conditions are individually rare, but collectively common: what if one therapy could treat multiple conditions? In diseases caused by early stop codons, prime edits were made (to a dispensable tRNA) so

Chemistry writes the story of life. Every cell, every second, it tells it again - powered by molecular design. At the core of this process lies the citric acid cycle, the central hub of metabolism. Here, acetyl-CoA derived from carbohydrates, fats, or proteins enters a precise

Are AI Tools Replacing Scientific Writing? Here's what some leading scientists have to say ⤵ Repost & Save (with 𝘤𝘭𝘪𝘱𝘱𝘦.𝘮𝘦) — Tools like ChatGPT are good helpers (but poor creators) — AI can speed up writing (but it's not ready to take over scientific thinking). — The

You're watching spacetime shear and glow around a compact mass...a Schwarzschild field with Kerr-lite hints. We layer time-dilation, gravitational-redshift tinting, Doppler/beaming on near-ISCO orbiters, photon-ring overtones, Shapiro-delay ripples, jet helices + shocks,

🔥 It's here: OpenFold3 is now live. THE open-source foundation model for predicting 3D structures of proteins, nucleic acids & small molecules. This is where the future of drug discovery and biomolecular AI lives. Built by @open_fold. Hosted on @huggingface. 👇 more

Introducing our new PhD student, Deepti Ramteke @DeeptiDR_29: Deepti joined IISER Mohali in 2023 as an integrated MS-PhD student. After her rotations/qualifier, she formally joined our lab. She will set up the C. elegans model system in my lab & study the biology of RNA granules.

Genetics might be more important for supplements than we thought New RCT: Magnesium increased vitamin D-synthesizing bacteria only in people with normal TRPM7 genes But those with TRPM7 variants saw decreased levels instead

🚨🧬 Want to build in drug discovery? Join the M-Boltz Hackathon (Oct 20–21, 2025) with @merckgroup & the awesome Boltz team! Tackle challenges in protein, nucleic acid & drug co-folding, scale cutting-edge models, and build the next wave of open science. (+ get to hang with

I am beyond excited and incredibly proud to share that our work is now out in @Nature . https://t.co/DaPQSUAdh2

periodic table of monosaccharides Richard D. Cummings #glycotime https://t.co/OQzTHyjf1l

Breaking news: scientists have finally created a Periodic Table of Monosaccharides! So next time someone says “sugar is simple,” just casually drop that there’s a whole periodic table for it. #glycotime