Todd Lab @UM
@realToddLab
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Peter K Todd MD/PhD Lab @Umich. We study how short tandem repeats impact neuronal function and human disease. Ataxia, ALS/FTD, Fragile X/FXTAS, CANVAS.
Ann Arbor, MI
Joined April 2018
It took a near-collapse of our research infrastructure and a constitutional crisis to make it happen, but we are moving our former Twitter activities to Bluesky. Looking forward to a happier scientific discussion in this new space:.
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If the PNAS version of the article is behind a paywall for you, the preprint is here:
biorxiv.org
Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Despite its intronic location,...
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@sh4nnonmiller @KatelynMGreen @BoyleLab @BarmadaLab @NINDSfunding @VAResearch actually that should be @alanboyle.bsky.social.
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This project was led by @sh4nnonmiller and @KatelynMGreen with help from @BoyleLab and @BarmadaLab and everyone in @realToddLab. Thanks to @NINDSfunding and @VAResearch for support!.
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Knowing the template for DPR production from RAN translation in C9orf72 FTD and ALS is a key first step to developing effective therapies for these currently untreatable conditions. 4/5.
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In contrast, we find no evidence for lariat RNAs or intron retention as endogenous templates for RAN translation, as both species are very rare and inefficient translation templates in neurons. 3/5.
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We used nanopore coupled to 5'RACE to find the 5' end of repeat containing RNAs. 95%+ of repeat RNAs initiate in the intron rather than at annotated start sites. These short (~80nt) 5' leader mRNAs are capped and polyadenylated and robustly translated in reporter assays. 2/5.
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Ever wonder how intronic repeats in C9orf72 get translated into toxic proteins in ALS? We found that transcription initiates within the intron to generate novel endogenous mRNA templates for RAN translation in patient neurons and mouse models. 1/5
pnas.org
Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemp...
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Bummed I missed it this year!.
Happy AUG1 RNA Day! We celebrated it by many great discussions at the Gordon conference on #ALS in the beautiful Portland ME. Many thanks to @LuVaDeBo Christine Vande Velde @BarmadaLab Magda Polymenidou for organizing it! @FrattaLab @RueppLab @smslmoon
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You deserve better. We all do.
Harvard notified me today that this K99 grant is terminated.
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Excited to organize this CSHL Asia meeting with @pengjinATL on Repeat Expansion Disorders. Hope you all can join us!.
Cold Spring Harbor Asia Meeting - Short Tandem Repeats in Gene Regulation and Disease @CSHANews
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RT @pengjinATL: Cold Spring Harbor Asia Meeting - Short Tandem Repeats in Gene Regulation and Disease @CSHANews
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RT @Nature: A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the….
nature.com
Nature - The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
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RT @EvaFeldmanMDPhD: Sharing a symposium on #RareDiseaseDay that will be held at the Kellogg Eye Center Auditorium. RSVP using this link:….
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RT @maxdkozlov: NEW: The Trump administration is exploiting a loophole to keep funding frozen at the NIH - a move that some legal experts s….
nature.com
Nature - The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
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RT @brainaddiction: Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because….
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RT @skippin_stones: 🏥 At @umichmedicine , patients receive world-class care thanks to our commitment to research, education, and clinical e….
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