Daniel Zhang
@danzhang122
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Neurosurgery resident @PennNSG. MD PhD @PennMedicine. @MIT alum. Passionate about neuro-oncology, cancer genomics, clinical trials. Conductor @PennMedSymphony
Philadelphia, PA
Joined May 2018
The Brain Prize 2025 was awarded for pioneering work on brain cancer by Frank Winkler and Michelle Monje. This short portrait film tells about their upbringing and scientific journeys, and also how treating patients inspires their work on these devastating diseases. #Neuroscience
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As presented at #ASCO25: Intracerebroventricular infusion of bivalent EGFR and IL13Rα2-targeting #CARTcells in patients with recurrent #glioblastoma was well tolerated with 1 patient with a partial response and 1 patient with durable stable disease
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1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! https://t.co/n9nxmr9dcM ,
nature.com
Nature Genetics - Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence,...
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A new study in Nature challenges long-standing views on how Group 3/4 #medulloblastomas develop. Study group led by Prof. S. Pfister argue that large-scale chromosomal alterations, not oncogene mutations, are the earliest events in tumor initiation. 🧵🧵🧵 1/n
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Also, a big shout out to @LogunMeghan @sun_yusha @XinW_up @StephenBagleyMD for their extraordinary work using GBM organoids as high-fidelity real-time models for CAR T cell therapy testing in parallel with a clinical trial
biorxiv.org
Patient-derived tumor organoids have been leveraged for disease modeling and preclinical studies, but rarely applied in real-time to aid with interpretation of patient treatment responses in clinics....
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So excited to share this study looking at the dynamic interplay between GBM and CAR T cells during treatment using organoids and single cell multi-omics! Hopefully this moves us toward a better understanding of #immunotherapy in #GBM. Huge thanks to @UPenn_SongMing @DrORourke2!
Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of ... https://t.co/GvmVJmnm6Z
#biorxiv_cancer
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So excited to share our work mapping out the extensive neuron-glioma connectome and discovering unexpected ‘synapses’ all across the brain! Congrats to @sun_yusha, the @UPenn_SongMing lab, and our brilliant collaborators @DrORourke2 @MacNasrallah and more!
Thrilled to share our new preprint! We leverage GBM organoids and monosynaptic rabies tracing to reveal the brain-wide connectome of this cancer, including a cholinergic neuron-tumor synapse that may fuel GBM invasion. @UPenn_SongMing #CancerNeuroscience
https://t.co/DTr2r6AwgX
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Incredible work! Especially the identification of underlying molecular mechanisms involved in functionally consequential glioma-neuron interactions. As with all great science, so many more questions to explore in #CancerNeuroscience and #glioma!
Patients with #glioma often experience altered cognition but it was unknown whether tumors remodel or destroy neuronal circuits in the human brain. New, open access #CancerNeuroscience paper: https://t.co/a0kcM30o51.
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Patients with #glioma often experience altered cognition but it was unknown whether tumors remodel or destroy neuronal circuits in the human brain. New, open access #CancerNeuroscience paper: https://t.co/a0kcM30o51.
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First rehearsal of 2023 conducting the @PennMedSymphony! We’ve got an incredible program this spring including Rimsky-Korsakov’s Scheherazade. Special shout-out to our concermaster @JoeInGenes for some exquisite solos!
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Very pleased to announce that @US_FDA has allowed the opening of our bivalent CART study for recurrent GBM at @PennMedicine @PennCancer @PennNSG that will build on our prior work to advance care for #glioblastoma
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This study found that autologous tumor lystate-loaded dendritic cell vaccination plus standard of care (SOC) was associated with improved survival in both newly diagnosed & recurrent glioblastoma compared with matched controls who received SOC treatment.
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.@KayvonPedram is a group leader in Janelia’s Molecular Tools & Imaging research area. He started his lab at Janelia in 2021 after finishing his PhD @StanfordUChem, working in the lab of @HHMINEWS Investigator @CarolynBertozzi. #WhoIsJanelia (1/5)
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Thrilled to announce yet another wonderful collaboration with @TiroshLab led by @hara_toshiro, @RChanoch at @WeizmannScience, @MGHPathology, @MGHCancerCenter, @broadinstitute describing cell-cell communication within the glioblastoma ecosystem that is out today @Cancer_Cell
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Offering a note of hope during #COVID19🎵🎻- Members of @PennMedSymphony spoke with @whyy about their recent experience recording & sharing a virtual performance of Edward Elgar’s “Nimrod” ft. @danzhang122, Alex Morrison & Ethan Pani (@PennMedicine) https://t.co/XlQ2VZ6wsu
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So happy to share, on this day of thanksgiving, a virtual performance by the @PennMedSymphony. https://t.co/BYSWgwnKsk Special thanks to @whyy for this wonderful article: https://t.co/Jquo8ZQpnP And to @JuliaHatmaker for incredible audio & video editing! @PennMedicine
whyy.org
The Penn Med Symphony Orchestra has created a virtual performance of a short piece by Edward Elgar as a Thanksgiving gift.
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Thank you for mentoring us @roelverhaak at #SNO2020 Meet the Computational Biologist session! Thank you @toddbart001 for moderating. Great to meet you @ElisaIzquierdo_ @neurogiselle @danzhang122 @yahayayabo ! @NeuroOnc
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Congrats to Hongjun Song @UPenn_SongMing @PennMedicine for his election to the @theNAMedicine!! What a special honor it has been to train with such an incredible mentor & scientist!!
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