Daniel Zhang
@danzhang122
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Neurosurgery resident @PennNSG. MD PhD @PennMedicine. @MIT alum. Passionate about neuro-oncology, cancer genomics, clinical trials. Conductor @PennMedSymphony
Philadelphia, PA
Joined May 2018
RT @NatureMedicine: As presented at #ASCO25: Intracerebroventricular infusion of bivalent EGFR and IL13Rα2-targeting #CARTcells in patients….
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RT @M_Nomura: 1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! , .
nature.com
Nature Genetics - Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence,...
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RT @LohiOlli: A new study in Nature challenges long-standing views on how Group 3/4 #medulloblastomas develop. Study group led by Prof. S.….
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Also, a big shout out to @LogunMeghan @sun_yusha @XinW_up @StephenBagleyMD for their extraordinary work using GBM organoids as high-fidelity real-time models for CAR T cell therapy testing in parallel with a clinical trial
biorxiv.org
Patient-derived tumor organoids have been leveraged for disease modeling and preclinical studies, but rarely applied in real-time to aid with interpretation of patient treatment responses in clinics....
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So excited to share this study looking at the dynamic interplay between GBM and CAR T cells during treatment using organoids and single cell multi-omics! Hopefully this moves us toward a better understanding of #immunotherapy in #GBM. Huge thanks to @UPenn_SongMing @DrORourke2!.
Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of . #biorxiv_cancer.
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So excited to share our work mapping out the extensive neuron-glioma connectome and discovering unexpected ‘synapses’ all across the brain! Congrats to @sun_yusha, the @UPenn_SongMing lab, and our brilliant collaborators @DrORourke2 @MacNasrallah and more!.
Thrilled to share our new preprint! We leverage GBM organoids and monosynaptic rabies tracing to reveal the brain-wide connectome of this cancer, including a cholinergic neuron-tumor synapse that may fuel GBM invasion. @UPenn_SongMing #CancerNeuroscience .
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Incredible work! Especially the identification of underlying molecular mechanisms involved in functionally consequential glioma-neuron interactions. As with all great science, so many more questions to explore in #CancerNeuroscience and #glioma!.
Patients with #glioma often experience altered cognition but it was unknown whether tumors remodel or destroy neuronal circuits in the human brain. New, open access #CancerNeuroscience paper:
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RT @HerveyJumper: Patients with #glioma often experience altered cognition but it was unknown whether tumors remodel or destroy neuronal ci….
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First rehearsal of 2023 conducting the @PennMedSymphony! We’ve got an incredible program this spring including Rimsky-Korsakov’s Scheherazade. Special shout-out to our concermaster @JoeInGenes for some exquisite solos!
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RT @DrORourke2: Very pleased to announce that @US_FDA has allowed the opening of our bivalent CART study for recurrent GBM at @PennMedi….
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RT @JAMAOnc: This study found that autologous tumor lystate-loaded dendritic cell vaccination plus standard of care (SOC) was associated wi….
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RT @HHMIJanelia: .@KayvonPedram is a group leader in Janelia’s Molecular Tools & Imaging research area. He started his lab at Janelia in 20….
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RT @MarioSuva: Thrilled to announce yet another wonderful collaboration with @TiroshLab led by @hara_toshiro, @RChanoch at @WeizmannScience….
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RT @PennMedEVDCSO: Offering a note of hope during #COVID19🎵🎻- Members of @PennMedSymphony spoke with @whyy about their recent experience re….
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So happy to share, on this day of thanksgiving, a virtual performance by the @PennMedSymphony. Special thanks to @whyy for this wonderful article: . And to @JuliaHatmaker for incredible audio & video editing!. @PennMedicine.
whyy.org
The Penn Med Symphony Orchestra has created a virtual performance of a short piece by Edward Elgar as a Thanksgiving gift.
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RT @virginiabhill: Thank you for mentoring us @roelverhaak at #SNO2020 Meet the Computational Biologist session! Thank you @toddbart001….
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Congrats to Hongjun Song @UPenn_SongMing @PennMedicine for his election to the @theNAMedicine!! What a special honor it has been to train with such an incredible mentor & scientist!!.
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