Yusha Sun
@sun_yusha
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MD/PhD student @PennMedicine @UPenn_SongMing | @Princeton @PrincetonPhys alum | Interested in neuro-oncology, cancer neuroscience, single-cell genomics
Philadelphia, PA
Joined June 2022
Super excited to share our recent work now out in @Nature! We introduce trans-synaptic tracing tools from circuit neuroscience to study the whole-brain connectome of glioblastoma.
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RT @zhoujoeyyi: Excited to share our study published in @NatureNeuro today! We conducted cross-species analyses of immature neurons arising….
nature.com
Nature Neuroscience - Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting...
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RT @stemcellreports: New research from @PennMedicine: Structural & functional cholinergic neuron-to-glioblastoma #synapses using an all-hum….
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RT @michelle_monje: Delighted to share our most recent #CancerNeuroscience study, led by brilliant postdoctoral fellows @RDrexler and@ADrin….
cell.com
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic...
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RT @organoidscience: New from Song and Ming Labs (@UPenn_SongMing)! . The team reports a co-culture system employing patient-derived #gliob….
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RT @PennMedCSO: Brothers Daniel & David Zhang followed similar paths in medicine & music at @PennMedicine & @PennMedSymphony. A new philant….
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RT @davidrliu: In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, stud….
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RT @CellPressNews: Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy.https….
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RT @AllenInstitute: How does the brain work?. Scientists are closer to the answer with the largest wiring diagram and functional map of a m….
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RT @BrainPrize: Congratulations to winners of The Brain Prize 2025!.Professors @michelle_monje, @StanfordMed and @HHMINEWS Investigator, an….
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RT @Jun_kiim: A groundbreaking study published in Nature (Jan 2025) significantly expanded our understanding of GBM-neural circuit interact….
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RT @michelle_monje: 1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc @TaraBarronPhD det….
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RT @zhoujoeyyi: Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in d….
biorxiv.org
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized...
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RT @Dr_CJackson: Thank you @NASBSorg for the opportunity to present our work in collaboration with @UPenn_SongMing developing skull base #c….
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RT @yanggy_hku: Our MR study suggests that GLP-1R activation improves mental health well-being and reduces risk of depression, bipolar diso….
medrxiv.org
Concerns have been raised about the psychiatric safety of glucagon-like peptide-1 receptor (GLP-1R) agonists, but trial evidence suggests that they ameliorate depressive symptoms. We aimed to assess...
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RT @DengYanxiang: Our spatial multi-omics technology that co-profiles five modalities is now published in Nature Methods @naturemethods! Hu….
nature.com
Nature Methods - Spatial-Mux-seq offers a multimodal spatial platform capable of profiling multiple molecular modalities, including the transcriptome, chromatin accessibility, histone modifications...
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RT @mansour_abed_A: Elegant and smart work by @UPenn_SongMing @sun_yusha using trans-synaptic tracing and GBM mouse transplantation to….
nature.com
Nature - A study leveraging transsynaptic tracing demonstrates rapid and extensive integration of human glioblastoma organoids into the mouse brain.
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RT @zhoujoeyyi: A new study in @Nature by the @UPenn_SongMing labs, led by @sun_yusha, has mapped circuit integration of glioblastoma organ….
nature.com
Nature - A study leveraging transsynaptic tracing demonstrates rapid and extensive integration of human glioblastoma organoids into the mouse brain.
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This has been an incredible journey and I am so grateful for my mentors @UPenn_SongMing, an amazing team in the lab @XinW_up, @danzhang122, Zhijian, @kristenhpark and many more. Special thanks to @minghongmaUPenn, @DrORourke2, @MacNasrallah @EmilyllPai @PennMedicine.
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We hope this study provides new tools for the study of #CancerNeuroscience and may eventually lead to a better understanding of this devastating disease.
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