Super excited to share our recent work now out in @Nature! We introduce trans-synaptic tracing tools from circuit neuroscience to study the whole-brain connectome of glioblastoma.

RT @stemcellreports: New research from @PennMedicine: Structural & functional cholinergic neuron-to-glioblastoma #synapses using an all-hum….

RT @michelle_monje: Delighted to share our most recent #CancerNeuroscience study, led by brilliant postdoctoral fellows @RDrexler and@ADrin….

RT @organoidscience: New from Song and Ming Labs (@UPenn_SongMing)! . The team reports a co-culture system employing patient-derived #gliob….

RT @PennMedCSO: Brothers Daniel & David Zhang followed similar paths in medicine & music at @PennMedicine & @PennMedSymphony. A new philant….

RT @davidrliu: In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, stud….

RT @QianXuyu: Today in @Nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specifica….

RT @CellPressNews: Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy.https….

RT @AllenInstitute: How does the brain work?. Scientists are closer to the answer with the largest wiring diagram and functional map of a m….

RT @BrainPrize: Congratulations to winners of The Brain Prize 2025!.Professors @michelle_monje, @StanfordMed and @HHMINEWS Investigator, an….

RT @Jun_kiim: A groundbreaking study published in Nature (Jan 2025) significantly expanded our understanding of GBM-neural circuit interact….

RT @michelle_monje: 1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc @TaraBarronPhD det….

RT @zhoujoeyyi: Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in d….

RT @Dr_CJackson: Thank you @NASBSorg for the opportunity to present our work in collaboration with @UPenn_SongMing developing skull base #c….

RT @yanggy_hku: Our MR study suggests that GLP-1R activation improves mental health well-being and reduces risk of depression, bipolar diso….

RT @DengYanxiang: Our spatial multi-omics technology that co-profiles five modalities is now published in Nature Methods @naturemethods! Hu….

RT @mansour_abed_A: Elegant and smart work by ⁦@UPenn_SongMing⁩ ⁦@sun_yusha⁩ using trans-synaptic tracing and GBM mouse transplantation to….

RT @zhoujoeyyi: A new study in @Nature by the @UPenn_SongMing labs, led by @sun_yusha, has mapped circuit integration of glioblastoma organ….

This has been an incredible journey and I am so grateful for my mentors @UPenn_SongMing, an amazing team in the lab @XinW_up, @danzhang122, Zhijian, @kristenhpark and many more. Special thanks to @minghongmaUPenn, @DrORourke2, @MacNasrallah @EmilyllPai @PennMedicine.

We hope this study provides new tools for the study of #CancerNeuroscience and may eventually lead to a better understanding of this devastating disease.

Monosynaptic herpes simplex virus tracing, immuno-electron microscopy, and functional assays all confirm a cholinergic neuron-to-glioma synapse. Acetylcholine may play a role in GBM invasion via the CHRM3 receptor, which is a potential therapeutic target.