Chris Hoyle
@choyle22
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Postdoc at the University of Manchester researching inflammasomes
Manchester, England
Joined November 2011
New MRC DTP PhD project is available with David Brough, Kevin Couper, Roy Ng and myself looking at the NLRP3 inflammasome in the brain and brain disease https://t.co/kz0Gk00c9B. Please get in touch with Prof Brough to discuss if you are interested! @BIG_research
findaphd.com
PhD Project - (MRC DTP) Targeting inflammasomes to reduce inflammatory damage in brain disease at The University of Manchester, listed on FindAPhD.com
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Have you submitted your abstract yet? Don't miss out on this great meeting! Fantastic line up (really!!) and great occasion for ECR to present their research for talks and poster!
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with @BSI_Inflam on 11–12 Sept in Manchester! Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July! ☑️ Submit your abstract & register: https://t.co/dZxCELfDR5
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NEW PAPER ALERT! 🚨 And it dropped on my bday, so thanks @braincomms! C9orf72 dipeptides activate the NLRP3 inflammasome 👇🏻👇🏻👇🏻 Huge thanks to @choyle22, @mere_conjecture, @ComorbidCath & the rest of the team not on X, plus @AlzSocResearch for funding. https://t.co/ReulPJsCT9
academic.oup.com
A C9orf72 repeat expansion causes frontotemporal dementia and amyotrophic lateral sclerosis. The expansion is translated to produce dipeptides that activat
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In some animals, a crucial protein has evolved to work differently, like a chef who no longer needs to be in the control room but still coordinates with the team for a more efficient kitchen. @choyle22 @Rose_Wellens
https://t.co/0fZkzhn6O7
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Our new paper exploring the nuclear role of pro-IL-1α is out now in Nature Comms! https://t.co/oVMuTy8zHA A first for myself as a first author and @choyle22 as corresponding author… go team!! 💪🏻 Such valuable work and support from all the other wonderful people involved ✨
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Big thanks to @Rose_Wellens for all of her work, and also to the rest of the team!
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We hypothesise that HAT binding may be the primary intracellular role of pro-IL-1α, and the NLS may serve an auxiliary role – either to facilitate binding to HATs in the nucleus, or instead it may be related to IL-1α trafficking and release
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Interestingly, species that have lost conservation of the IL-1α NLS have maintained conservation of the HAT-binding domains. Monotremes also have evidence of an intact NLS in IL-1α, suggesting that the NLS evolved in the proto-mammal, prior to mammalian divergence.
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By analysing evolutionary evidence, we found that in addition to toothed whales ( https://t.co/68kZhrW33L), other mammals such as castorimorpha (e.g. beavers) and marsupials have lost IL-1α NLS conservation. We validated that these mutations cause loss of nuclear localisation
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Using proximity labelling, we identified proteins within close proximity to pro-IL-1α, including many nuclear proteins and specifically various HAT proteins, such as EP300. These data suggested that interaction with nuclear HATs could be an intracellular role for IL-1α
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IL-1α has a highly conserved nuclear localisation sequence (NLS) in the pro-domain, which facilitates trafficking of pro-IL-1α to the nucleus, and two HAT-binding domains. Why does IL-1α have an NLS, and does IL-1α have a role in the nucleus?
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NEW PAPER: https://t.co/uFk4I4Ha4s Summary: We delve into the nuclear role of pro-IL-1α, using proximity labelling to identify several proteins that may interact with pro-IL-1α in the nucleus, including HATs, and find many species that have lost IL-1α nuclear localisation
nature.com
Nature Communications - Interleukin (IL)-1α is a critical inflammatory cytokine and yet its intracellular role is poorly understood. Here, the authors use proximity labelling of pro-IL-1α...
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Our paper is now out in @CellReports! Please give it a read, particularly those interested in #microglia, #macrophages, and #stroke. We show the MNP response to stroke is all about where you're from (ontogeny), where you're at (space), and where youre heading (substates).
Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
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My first ever research paper is out !! 👩🏼🔬🎉 👉👉 https://t.co/GoDwQC3MwO A natural product "brazilin" inhibits the NLRP3 inflammasome pathway, a key driver of numerous inflammatory human diseases including those affecting the brain such as stroke and dementia.
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An exciting PhD opportunity to join my lab studying NLRP3 inflammasome in vascular dementia. This project is in collaboration with @KasherLab Prof. David Brough, and Dr. Ingo Schiessl. Please contact me for details (roychun-laam.ng@manchester.ac.uk) https://t.co/BvTbPT9eU3
findaphd.com
PhD Project - (MRC DTP) Study of the crosstalk between adiponectin and NLRP3-inflammasome pathways in vascular dementia at The University of Manchester, listed on FindAPhD.com
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⚠️ New #NF2 research paper out! I am elated! Are #NF2SWN #vestibularschwannoma similar or different to sporadic tumours? Read the paper or the video abstract to find out! https://t.co/GBhYg5LnGc Thanks to our fab authors and funders @nf2biosolution1 @NF2BioSolutions @DNS_UOM
NF2-related schwannoma & sporadic vestibular schwannoma: same tumour or different? See our recent paper to find out! @GJBrainResearch @SNOMAN_Lab @MCCN_UK @LydiaBeckerIII @NCAresearchNHS @MCRskullbase
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Happy to share that our paper on the discovery of compounds that inhibit the AIM2 inflammasome is now published 🥳 – Check it out here
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Studying various cell lines, researchers probe the inflammasome #NLRP3 and show how disruptions to #endosomal trafficking can sensitize macrophages to NLRP3 activators, enhancing inflammasome activation and cytokine secretion. @FBMH_UoM
https://t.co/dVTmxysW2J
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Happy that our latest paper on NLRP3 activation is out, great work by @BaliCLee @wellens_rose and everyone else!!
science.org
The NLRP3 inflammasome senses and is activated by perturbations in endosomal trafficking.
Beyond thrilled to have our research published in @scisignal AND to get the front cover 🤯🔬 The teamwork that went into this paper is something that we’re all very proud of🧪@choyle22 @drjackpgreen @UoM_GEU @BillieJMatchett @Glo_loca
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Beyond thrilled to have our research published in @scisignal AND to get the front cover 🤯🔬 The teamwork that went into this paper is something that we’re all very proud of🧪@choyle22 @drjackpgreen @UoM_GEU @BillieJMatchett @Glo_loca
A study ties an inflammatory protein complex’s activity to “traffic jams” in cell cargo transport, research in cells reveals how a kinase helps insulin regulate cell metabolism, and more in this week’s new issue of #ScienceSignaling. https://t.co/UxxrUET4To
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