Gaurav et al. demonstrated that posteroventral nigral iron accumulation correlates with disease progression and dopaminergic denervation in PD. QSM was more sensitive and robust than R2* for detecting regional nigral iron abnormalities. Read at

Crowley et al. explored CD4+ T cell heterogeneity in experimental autoimmune encephalomyelitis and multiple sclerosis (MS). Using single-cell RNA sequencing and spectral flow cytometry, they identified distinct phase- and cluster-specific markers. Read at

Marcelino and Al-Fatly et al. report literature-based lesion network mapping of dyskinetic cerebral palsy. Grey matter lesions are the most common MRI finding; the motor thalamus is a converging node of a wide functional network. Read at

Gonzalez-Ortiz et al. report plasma p-tau217 measurement in newborns; levels are significantly higher in healthy newborns than in AD patients. Levels of serum p-tau217 in premature newborns remain increased up to 18 weeks post birth (.@Rantes

Zeng et al. characterize familial adult myoclonus epilepsy type 1 using HiFi long-read sequencing, highliting clinical features, highly unstable expanded SAMD12 TTTTA/TTTCA repeats, and an inverse correlation between repeat size and age of onset. Read at

Kövesdi et al. report that the nonsteroidal anti-inflammatory drug meclofenamate reduces seizure severity after systemic kainic acid injection via blocking transient receptor potential melastatin channel 4 in hippocampal mossy cells. Read at

Sarah Jonker et al. studied essential tremor patientsusing FDG-PET; changes in brain metabolism further support the cerebello-thalamo-cortical circuit in the network disorder, but point also towards altered sensorimotor integration. Read at

Using whole-genome sequencing, Barbier et al. report intermediate alleles of huntingtin linked to early ALS/dementia onset, highlighting links between C9orf72 and polyglutamine disorders and emphasizing short-tandem-repeats in disease variability. Read at

Kumar et al. identified four clinical phenotypes and their neuroanatomical cortical network correlates in a well-characterized cohort of chronic traumatic brain injury. Read at @raj_kumarphd, @DamsOConnor, @ComaRecoveryLab, @YelenaBodien

Dirren et al. compared network properties after simulating recurrent strokes; they found that patients’ brain networks showed greater resilience, being less affected by recurrent virtual lesions compared to controls. Read at

Cataldo et al. analyzed body disonwership post-brain damage, demonstrating that subtle disownerships are undetected post-stroke, and suggesting the role of complex bilateral brain networks in the construction of body awareness in humans. Read at

Saccade eye tracking can yield quantitative, real-time measurements of memory behaviour. patients with temporal lobe epilepsy demonstrate a less efficient visual search compared to healthy controls, suggesting a weaker memory trace. Read at

West and Natalwala et al. report on the first Parkinson’s α-synuclein mutation rat model. A single glycine-to-aspartic acid change at codon 51 in the Snca gene reduced localisation of αSyn to synapses and increased Lewy pathology acquisition. Read at

Martín-Saladich et al. studied brain glucose hypo- and hypermetabolism in Type 2 diabetes, linking insulin resistance to risk of cognitive impairment; a biomarker-based, non-invasive model enabled at-risk patient detection. Read at

We're excited to announce that, following research indicating that Bluesky has surpassed X as the preferred social media platform for academic publications, #Bluesky has been added as the first option for the "Share" button in Brain Communication journal publications 🎉 🥂

Zapparoli et al. reported that individuals with body integrity dysphoria (BID) show heightened limbic and reward-related brain activation from tactile stimulation of the affected limb, suggesting altered somatosensory and affective processing. Read at

Cheng et al. report that analysing structural brain changes using advanced segmentation reveals robust associations of AD CSF biomarkers with brain volume, morphometric connectome and sex differences. Read at

In a multiple sclerosis patient cohort, Hemond et al. observe a 98% specificity for paramagnetic (iron) rims on MRI as discriminating MS from mimics, emphasizing that ‘low confidence’ paramagnetic rim inclusion reduces discriminative specificity. Read at

Bell et al. report that multisite chronic pain, unlike single-site, in older adults is linked to faster cognitive decline and increased AD pathology, particularly in APOE-ɛ4 carriers. This supports multisite pain as a risk factor for AD dementia. Read at

Fu et al. investigate MRI features of normal pressure hydrocephalus in Parkinsonian disorders. The features were associated with unique clinical and neuroimaging pictures, and progressive supranuclear palsy, the latter potentially a pathomechanism. Read at