RT @Schmidt_Center: 🎉Congratulations to @Schmidt_Center PhD fellow @Jakob_German and the team on their new @NatureGenetics paper! They show….

RT @andganna: 🚨 New paper 🚨. Do known genetic factors for obesity affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?. 🔍 10,960….

9/ Big thanks to the whole team! Especially grateful to my mentors @andganna and Anthony Philippakis. Shoutout to @tigerstatdoc, Zhiyu Yang, @pecsi_max, @FinnGen_FI, @pnatarajanmd, @zkutalik and @elipatorno for all the support and teamwork!.

8/ How do you think genetics could further enhance clinical trials? Let’s discuss! Read our findings and share your thoughts:

7/ Takeaway: Integrating genetics into trial emulations enhances study design and strengthens real-world evidence. While genetics alone doesn’t fully resolve confounding, it’s a powerful tool that complements traditional methods for more robust results.

6/ This approach allows for smarter, more efficient trial designs that maximize impact. By applying genetic insights, we can focus trials on the most relevant groups, improving relevance and cost-effectiveness.

5/ Emulated trials offer a powerful way to evaluate the prognostic and predictive enrichment potential of PGS. Testing enrichment within an emulated trial, rather than the general population, ensures that genetic insights truly enhance the RCT design and aren’t misleading.

4/ Although genetics alone may not fully control for confounding in emulated trials (as shown in our simulations), Mendelian Randomization can help identify residual confounders. This approach flags influences that remain, even after matching.

3/ Much like voting demographics, genetic differences between trial arms can reveal biases in study design. Through PGS, we identified hidden confounders, allowing for more balanced and precise results—crucial for evidence-based medicine as the nation votes today #Vote2024

2/ In our study, we successfully replicated the results of 4 major cardiometabolic trials. Leveraging genetic data from 425K individuals in FinnGen, we then asked: Can polygenic scores (PGS) help refine trial emulations?

1/ Just as elections shape our nation’s future, clinical trials shape critical health decisions. Emulating randomized controlled trials (RCTs) with real-world data is advancing rapidly—now further strengthened with genetic insights.

🚀Excited to share our new preprint on integrating genetic data into target trial emulations to improve clinical study design! On #electionday2024 and the first day of #ASHG24, our work highlights how genetic insights can bring greater rigor and clarity to real-world evidence🧬🧵

7/ Takeaway: Integrating genetics into trial emulations enhances study design and strengthens real-world evidence. While genetics alone doesn’t fully resolve confounding, it’s a powerful tool that complements traditional methods for more robust results.

6/ This approach allows for smarter, more efficient trial designs that maximize impact. By applying genetic insights, we can focus trials on the most relevant groups, improving relevance and cost-effectiveness.

5/8 Emulated trials offer a powerful way to evaluate the prognostic and predictive enrichment potential of PGS. Testing enrichment within an emulated trial, rather than the general population, ensures that genetic insights truly enhance the RCT design and aren’t misleading.

4/ Although genetics alone may not fully control for confounding in emulated trials (as shown in our simulations), Mendelian Randomization can help identify residual confounders. This approach flags influences that remain, even after matching.

3/ Much like voting demographics, genetic differences between trial arms can reveal biases in study design. Through PGS, we identified hidden confounders, allowing for more balanced and precise results—crucial for evidence-based medicine as the nation votes today #Vote2024

2/ In our study, we successfully replicated the results of 4 major cardiometabolic trials. Leveraging genetic data from 425K individuals in FinnGen, we then asked: Can polygenic scores (PGS) help refine trial emulations?

1/ Just as elections shape our nation’s future, clinical trials shape critical health decisions. Emulating randomized controlled trials (RCTs) with real-world data is advancing rapidly—now further strengthened with genetic insights.

8/ Grateful to all my amazing co-authors and collaborators for their invaluable contributions to this work! 🙌.I'd like to thank:.@tigerstatdoc, @ukuv, @roelof_aj_smit, @pnatarajanmd, @l_szczerbinski, @HHeyne, @drHamdiMbarek, @bpasaniuc and many more for making this possible!.