Chris Anderson
@CDAndersonMD
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Cerebrovascular health enthusiast. BWH/Harvard/Broad Institute. My expressed opinions are solely my own.
Boston, MA
Joined September 2017
Among the things hospitals teach you is a deep respect for disease. It is really hard to move the needle. We won't "cure all disease in 10 years". And there's a good change that medicine will still look much the same a decade from now.
https://t.co/KWc3DRv7B7 Demis Hassabis: We can probably cure all diseases in the next 10 years But investor Masayoshi Son said the same thing recently when $500 billion was invested in Project Stargate. All we need is scale. More computing power, better algorithms.
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#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals
https://t.co/3IAFCL6Sc9
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Our study in @NephrologyJourn explores the interplay between #CKD and ischemic #stroke. Findings highlight the need for integrated care strategies to improve outcomes and reduce stroke risk in CKD patients. @leonardyeo1 @ClaraNgoh @CDAndersonMD
https://t.co/p6UWxtVQCO
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Spatial proteomics in human carotid atherosclerotic plaques (N=118). A great weekend read❗️ 👉subregions isolated with microdissection (lipid core, fibrous cap, tunica media) 👉mass-spec proteomics 👉proteome-defined subclusters across subregions 👉biological enrichment across
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Thanks Tom. You’ve done so much for the field that I appreciate this tremendously.
New review article by Chris Anderson @CDAndersonMD on Genetics of intracerebral hemorrhage
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Another key resource for CNS genomic and drug target discovery research❗️ 👉pQTLs for 6,361 CSF proteins (SomaScan aptamers) 👉N=3,506 samples 👉3,885 associations for 1,883 proteins 📜paper: https://t.co/1oS9Jty3uC 📊summ stats: https://t.co/P48e0oCwNF
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We made a lot of effort to put all summary statistics available. There are in four different places: 1) NIAGADS: https://t.co/ic2z8MrZ1T, 2) GWAS catalog, GCST90317902–GCST903193033, 3) Pheweb browser https://t.co/LTkW5oxVbP, and 4) our website:
neurogenomics.wustl.edu
Raw data for the manuscripts published by NGI investigators can be found in NIAGADS, and Synapse. GWAS meta-analysis of CSF Alzheimer’s disease biomarkers 18,948 individuals reveal novel loci…
📰🔓Free early preprint version: https://t.co/9eH4D79QyP 📊Browsable results: https://t.co/6jnMM4E0iR The data could be really valuable for downstream analyses of cerebrovascular, neurodegenerative, psychiatric, or other CNS traits. Thanks @ccrugom and team🙏
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You're never behind the genetic 8-ball. Making healthy lifestyle choices reduces your risk of age-related brain disease even if you have a genetic predilection. https://t.co/SWT6wSB37k.
@BWHNeurology @MGHNeurology @CGM_MGH @broadinstitute
neurology.org
Background and ObjectivesThe 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of...
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Comprehensive proteome-wide Mendelian randomization for 355 phenotypes in 3 ancestries 👉N=35,559 European, 1,871 African, 1,823 East Asian 👉SomaScan & Olink 👉extensive sensitivity analyses 📊Results browsable here: https://t.co/Sw8ZsjbG8J 📰Preprint: https://t.co/khUzeNdWyr
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I extend my deepest gratitude to my co-authors @rainermpg, @sdorodgar, @VineetRaghu2, @pnatarajanmd, @BellomoTiffany, and @CDAndersonMD for their invaluable contributions, and especially to my PI @MariosGeorgakis for making this possible and for his immense support
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Many cool findings & a great resource for future research in atherosclerosis 📊GWAS summ stats to be posted on @GWASCatalog Phenomenal work by star @Murad__Omarov⭐️ Great collaboration with @CDAndersonMD @rainermpg
@sdorodgar @VineetRaghu2 @pnatarajanmd @BellomoTiffany
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Many thanks to study co-authors @lucidtronix, @ShinoKany, Rahul Mahajan, Clay Turner, @steven_lubitz, @MahnazMaddah and 🙏 as always for mentorship @patrick_ellinor, @CDAndersonMD
@broadinstitute @MGHHeartHealth @MassGeneralNews
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🚨Postdoc Opening🚨 We're seeking a skilled scientist to lead research in multiomics❗️ Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease Lab: https://t.co/lWl8pe5AbM Position: https://t.co/gumHahkZ58 Please RT!
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- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit
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The effects of a polygenic risk score for BMI on obesity and obesity-related morbidities are offset by a healthy lifestyle 🧬🍲🏃♀️ 👉evidence of additive & multiplicative interaction 👉high PRS ⬆️ the effect of unhealthy lifestyle on obesity risk https://t.co/1CTZzhmsCr
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Honored to have you join the faculty Priya. Great things now and ahead.
#NewFaculty Dr. Priya Srikanth will join the Divisions of @BWHNeuroICU and Neurorecovery at @MassGenBrigham on July 1. Welcome, Priya!
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GWAS of 2024 AI-derived (mainly imaging) human disease endophenotypes, including genetic correlations and Mendelian randomization associations with disease endpoints🧬 Summary stats to be made available upon publication https://t.co/My7Jo8xiWi
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Excited to share our study investigating the genetics of combined lipid patterns led by @tgillilandmd @jsdron! https://t.co/byTx0y9ygS
@CircRes [1/8]
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#HappeningNow BWH Neuroscience Day 2024 continues with poster presentations from across the department. 👩🔬 🧠
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