Thrilled to see our latest paper on the action of the melanocortin system in the carotid body published in @CircRes #hypertension #MC4R https://t.co/A1A0V4IuFr Here's the breakdown of key findings 1/6🧵

Pauza & colleagues found that #MC4R is upregulated in the carotid body in #hypertension, driving pathological chemoreflex activity. Learn more at https://t.co/xtZldttWEz @audrysgp @Param191 @vasopressinUoB @daveyboyhod @BroichhagenJ

🚨New research reveals an overactive ‘fight-or-flight’ stress reflex may increase heart strain. This could help unlock ways to reduce heart attack and stroke risk. Congrats to 3 Heart Foundation-funded researchers and @AucklandUni on their research published in a top journal!

@CircRes Sept 12th Issue is Out! https://t.co/IiX6g6rOKd Cover: image are the chemosensory GCs (cyan) scattered throughout a dense capillary network (grey) supplying the organ & innervated by numerous sensory NFs (orange) transmitting reflex information to the brain.

Also, a huge thank you to Mateus Amorim and Vsevolod Polotsky for the editorial and @CircRes for featuring us on the cover: https://t.co/0PCNSqQkm6 6/6

Could not have done it without @Param191, @daveyboyhod, @BroichhagenJ, @KilianR1, @FionaMcbryde, @vasopressinUoB, @FMHS_UoA and the rest of the team, not X. 5/6

Interesting to reflect our findings with biopharma refocusing to MC4R for drugs targeting genetic obesity as well as appetite loss - https://t.co/JOVfkB3Rj8 4/6

In this new paper, we demonstrate that melanocortin receptor agonists potentiate carotid body-evoked afferent activity and response sensitivity to hypoxia 3/6

In our earlier @CircRes paper ( https://t.co/ZLaiHbab6E), we found MC4R as the top upregulated #GPCR in the carotid body of spontaneously hypertensive rats (SHR) compared to age- and sex-matched normotensive controls. 2/5

Thrilled to see our brilliant Dr Olivia Gold @FMHS_UoA in @NatRevNeurosci. Her perspective calls for alternatives beyond naloxone to tackle opioid harm:

in caHOOts with #carotidbody

Age-related ciliopathy of MC4R neurons is presented as a crucial mechanism underlying age-related #obesity which increases the risk of metabolic syndrome @Cell_Metabolism

free book: Data Science at the Command Line Obtain, Scrub, Explore, and Model Data with Unix Power Tools https://t.co/NsePwvJrY6

I released a first version of a book on data visualization with R & ggplot2. Target audience = wet lab scientists. It's work in progress, so any feedback/suggestions/comments are appreciated!! #DataViz #Rstats https://t.co/qkLCD7UM8v

🔬My sc/spatial genomics lab (Launch at #Stanford on Dec. 16) is seeking experimental RAs & post-docs in genomics & dev bio. Come to work with me and a vibrant team of sys biologists, ML experts, etc. to push the boundaries of gene regulation of development & disease. #HiringNow

Congratulations to our #EarlyInvestigatorPrize winner in Cardiovascular/Respiratory Physiology: Ana Sayegh! Ana's article examined sex differences in neurocirculatory responses to chemoreflex activation: https://t.co/8TB8yd2opK See all the winners here:

Proud that our OASIS 1 paper making it to the cover of @TheLancet🙏

We are the International Society of Autonomic Neuroscience! We have represented scientists, clinicians, engineers, trainees, and industry partners at the forefront of autonomic research since establishment in 1995.

What is the correlation?

Our May 2023 issue is now available! Including content on: The carotid body🫀🦠 Ketogenic bars💪🍫 cerebral artery blood velocity🩸⏩ AND more! 📸@Param191, @Audrysgp, David Murphy and Julian F. R. Paton 🔗 https://t.co/Nqs0WvXvw5