Aditya Mojumdar
@adityamoj
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Biochemist, Molecular biologist, Yeast biologist fascinated by the mechanisms maintaining Genome integrity.
Victoria, British Columbia
Joined August 2016
A new report from our lab @jcobb_cobb @UVicBCMB shows that the transiently formed RNA:DNA hybrids at DNA double-strand breaks regulate end resection and promote EJ. Dna2 nuclease removes these hybrids and enables resection at DSB. @biorxivpreprint
https://t.co/bLQXcqxkTG
biorxiv.org
DNA double-strand breaks (DSBs) are highly detrimental to cells, as improper repair can result in inheritable genetic rearrangements or cell death. The role of RNA:DNA hybrids (RDHs) in DSB repair...
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This study from our lab reveals a Cross talk of the two main nucleases in maintaining the genomic integrity. @jcobb_cobb @UVicBCMB @jbiolchem
New in JBC press: "Loss of Dna2 fidelity results in decreased Exo1-mediated resection at DNA double strand breaks." Learn more: https://t.co/atVJ8XD9FU
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📢1 WEEK TO GO📢 The registration and poster abstract submission deadlines for #Genreg24 are on Monday 11th December 2023. Register and submit your abstract now to join us in Mexico in February! 🇲🇽☀️
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Another layer of the complex interplay of DSB repair factors revealed in this new study from our lab with @jcobb_cobb @uvic @Biochemistry @yeast_papers @biorxivpreprint
#DSBRepair #NHEJ #altEJ
biorxiv.org
A DNA double strand break (DSB) is one of the most dangerous types of DNA damage that is repaired largely by homologous recombination (HR) or non-homologous end-joining (NHEJ). The interplay of...
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1/2 Happy to share our latest study in @CellReports from @Bartek_Lab ! We unveil a role for MDC1 in transcription by regulating RNA Pol II! Huge congrats to our talented PhD student @geo_pappas
https://t.co/52Tybtz6Q6
cell.com
Pappas et al. show that MDC1 is necessary to regulate the RNA polymerase II (RNAPII)-dependent transcription in normal conditions and upon DNA damage. In MDC1-depleted cells, the abundance of the...
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3/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. @jcobb_cobb @JMolBiol Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.
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2/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. @jcobb_cobb @repair_dna Multifunctional properties of Nej1XLF C-terminus promote end-joining a...
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1/3 - While humans were social distancing, DNA double strand break repair factors were crosstalking. @jcobb_cobb @jbiolchem Nej1 interacts with Sae2 at DNA double-stranded breaks to inhibit DNA resection
jbc.org
The two major pathways of DNA double-strand break repair, nonhomologous end-joining and homologous recombination, are highly conserved from yeast to mammals. The regulation of 5′-DNA resection...
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Doing good science is finding the right balance between thinking small: obsessing over the minute details of a problem by mastering a given set of tools & thinking big: being receptive to having new (often strange) ideas from outside your field change how you think of a problem.
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As someone who is a slow thinker I've always thought we in science put too much emphasis on fast thinking, Q&As, chalk talks, thesis exams, many classroom interactions are geared towards rewarding speed. But in science what matters is not who thinks fastest but who thinks deepest
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Check out our @jcobb_cobb work that provides insight about age-related molecular changes in DSB repair, where both canonical pathways - HR and NHEJ become disrupted and cells gradually move towards error-prone DSB repair increasing the mutational burden.
biorxiv.org
A double -strand break (DSB) is one of the most deleterious forms of DNA damage. In eukaryotic cells, two main repair pathways have evolved to repair DSBs, homologous recombination (HR) and non-hom...
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New work from the lab showing that upon appearance of DNA breaks RNA editing by ADARs contributes to fine tune the response. Among other things, it helps to remove DNA:RNA hybrids to expedite DNA resection. Read the whole story at @NatureComms
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Here is a summary of the latest #COVID19AB numbers: There are currently 284 people in hospital due to COVID-19. Of the 225 non-ICU, 80% are unvaccinated or partially vaccinated. Of the 59 in ICU, 98.3% are unvaccinated or partially vaccinated. (1/4)
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Well said. Please follow the lead of other Canadian Universities @UCalgary @teribalser so faculty can safely teach in person without fear of bringing home COVID to their unvaccinated child. Or immunocompromised parent. So many reasons....to put vaccine and mask mandates in place.
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Very happy to share our paper on a new physical interaction of BLM with MCM in unperturbed G1 and S. Untethering Blm/Mcm6 leads to supra-normal replication speed that requires Blm ATPase activity. Congrats to two amazing 🙌 grad students. Details in:
academic.oup.com
Abstract. The Bloom syndrome DNA helicase BLM contributes to chromosome stability through its roles in double-strand break repair by homologous recombinati
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This! @jcobb_cobb
What if we all made a promise when reviewing manuscripts not to demand any extra experiments but just ask authors to 1) fix formatting, missing refs, errors in text, 2) moderate overzealous claims, 3) honestly admit pitfalls in their study that could be addressed in future work?
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Very thrilled to anounce that our review has been accepted in @FrontGenetics. The manuscript will be online soon 🎉🎉.
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Single-molecule Fluorescence Technique to Monitor the Co-transcriptional Formation of G-quadruplex and R-loop Structures
pubmed.ncbi.nlm.nih.gov
G-quadruplexes (GQ) and R-loops are non-canonical nucleic acid structures related to gene regulation and genome instability that can be formed during transcription; however, their formation mechani...
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Really nice review in @TrendsGenetics by @SarahLa47195747 et al. on the modulation of NHEJ #DNA_repair by RNAs, with beautiful & informative schemes.
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