Mitochondria are now widely recognized as regulatory hubs that extend far beyond their canonical role in energy production. Acting at the crossroads of metab...

IntroductionRAB11A, a Rab GTPase, is crucial for intracellular transport and recycling. Recently, RAB11A mutations have been found to be associated with neur...

IntroductionDetection of variance quantitative trait loci (vQTL) can facilitate the discovery of gene-environment (GxE) and gene-gene interactions (GxG). Ide...

The regulation of gene expression is influenced by multiple factors, including species origin, tissue specificity, developmental stage, and sex differences. ...

Correction: Engineering novel features for diabetes complication prediction using synthetic electronic health records Corresponding author Incorrect author a...

Traditional classifications of New World cichlids have been subject to persistent controversy. Within the genus Biotodoma, only two species are currently rec...

Stroke poses a serious threat to human health and life, serving as a leading cause of death and disability in adults. The incidence rate of stroke continues ...

Intrauterine adhesion (IUA) is characterized by endometrial fibrosis, posing significant risks to women’s reproductive health and fertility. This study aimed...

BackgroundAlport syndrome (AS) is an inherited disorder affecting basement membrane collagen IV. AS is characterized by hematuria and progressive renal failu...

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of these cases. Desp...

Polyploidy, or whole-genome duplication (WGD), is a significant evolutionary force. Following allopolyploidy, duplicate gene copies (homeologs) have divergen...

Codon usage bias (CUB), a universal evolutionary phenomenon, reflects selective pressures shaping genome adaptation. The WRKY transcription factor family pla...

IntroductionAccurately predicting the on-target activity of sgRNAs remains a challenge in CRISPR-Cas9 applications, due to the limited generalization of exis...

Several missense mutations in the LRRK2 gene are linked to familial Parkinson’s disease (PD). Although LRRK2 mutant mouse models typically lack gross motor i...

This study employed Yili horses participating in a 5000-meter race as a model to investigate exercise-induced gene expression alterations in peripheral blood...

Prime editing (PE) enables precise genome modification, i.e., all 12 types of base substitution, as well as designed insertion and deletion. Previously, we d...

countries, these innovations have become integrated into standard clinical care, allowing for 30 treatments tailored to individual characteristics. However, ...

BackgroundMultiple myeloma (MM) is an incurable plasma cell malignancy with high heterogeneity. Current staging systems, including the International Staging ...

Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, including fetal morbidity and mortality. It is a ...

Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by Aβ plaques, tau protein neuronal fiber tangles, and neuroinflammation, po...