Tom Longden
@_TomLongden
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Assistant Prof #UMBaltimore | Physiology | Neuroscience | Brain blood flow | Ion channels| GPCRs | Opinions are my own
Baltimore, MD
Joined August 2011
Delighted to end 2022 with our first paper out today in @CellReports, and our image on the cover! Huge congratulations to first author Ashwini Hariharan!! We show #brain #pericytes increase blood flow to decreased local energy availability to preserve energy supply to #neurons.
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📰Latest from our lab (Open Access)! Brain Capillary Ion Channels: Physiology and Channelopathies This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries @physiol_journal @APSPublications @APSPhysiology
https://t.co/NXfOPI0N5B
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Many thanks to @RoseEDixon1, @JonSilva_Stl & @FASEBorg for organising a wonderful Ion Channel SRC. A week of cutting edge science, engaging, respectful, discussion & real collegiality. Great to see the next generation of channel scientists coming through. Super job #ICRSRC 👏👏👏
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🚨Our new paper in Circ Research on the cover + 📖 editorial by Dr. Jackson 🔗 https://t.co/qj2gFGgLhM 👏 Danielle Jeffrey https://t.co/i8Tpfl2qND ♀️ Female mice show lower hippocampal tone 🌸 Estrogen-dependent, partly NO⚡️ SK channels dominate 🤝 @OsamaHarraz 💡 @LudemanCenter
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🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by @vesselman 🧠🧪 Check it out: https://t.co/3hMjSZ9v6C
@AMCPharmacology @CUAnschutz #Neurovascular #TRP
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Today at 12PM EST!
We cannot wait to welcome Dr. Ashwini Hariharan and listen to her ⭐️EpIC⭐️ seminar about pericytes and 🧠 brain blood flow on Tue March 5th (12PM EST)! EpIC seminars are FREE and open to all. Please, register https://t.co/eIILtwYWjH (if you are not) and spread the word.
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Congratulations to @OsamaHarraz for receiving the Bloomfield Early Career Professorship of @uvmvermont, @UVMLarnerMed @uvmcvri! A rising superstar in our Center!
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Self-Net is a new #DeepLearning method for improving the axial resolution of conventional volumetric fluorescence #Microscopy data, promising a fast and robust approach for attaining isotropic resolution and demonstrated using multiple imaging modalities: https://t.co/Y19kAU7IIz
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Molecular Physiology at UVA has a new faculty search! Come join one of the top ranked Physiology departments, and collaborate with our dynamic and awesome set of colleagues. We are especially strong in cardiovascular, membrane, structural, and biophysics.
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Forgot to mention at the end of my talk that I’m looking for grad students/postdocs/res scientists curious about how the pacemaker rate adapts. If you are interested let me know!!!
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Excited to share our latest manuscript examining the effects of intraluminal pressure on intact retina pericytes. @NelsonLab1 @MariaSancho0 @GonzalesLab1 @rochell
https://t.co/dyyBfWtkTr
pnas.org
Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood flow in the central nervous system in the face of fluctuat...
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Great to see our article on #pericyte control of blood flow in #brain and #heart out in @AnnualReviews. The result of a great collaboration with the Lederer lab here at @UMBaltimore! https://t.co/EIHBaGUkB1
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Very cool potential applications!
Microrobots in the brain Vasculature! We use microrobots and control them wirelessly in the brain vessels (even against the flow). We are just at the beginning of this exciting field. What kind of application do you imagine? https://t.co/61Y7AumrXJ
#innovation #medtech
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The flexibility of your brain energy supply decreses with age. Our new publication in Nature Aging shows that a decrease in vascular reactivity underlies this reduction in homeostatic reserve and possibly brain frailty.
Online now! In vivo 4D #2-photon imaging study reports an age-related decrease in mouse brain microvessels responsivity, decrease in vessel density & loss of vascular mural cell process @MartinMlauritz @ChangsiCai @transneuro_lab
https://t.co/KmKvrpzMQC
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Exceptional new reviews of the 12 interconnected biologic hallmarks of aging @CellCellPress and cancer @Cell_Metabolism
https://t.co/WViWtj4NK6
https://t.co/WRDQokSbiZ
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Happy New Year! Excited to share our new work @eLife on a unique desensitization mechanism of proton-activated chloride channel Last of a series of beautiful work on PAC by amazing @JamesOOwusu1 Kudos also to long-term collaborator @ZhengRuan5 @DuLuLabs
https://t.co/tWS6j5kDB5
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So excited that @vcoelhosantos is kicking off her own lab! A great opportunity to work with an energetic and inspiring young PI focused on development of the cerebrovasculature.
I am available to receive students and support PhD applications for @BecariosFLC / @CaixaResearch Find all the info here 👇 https://t.co/gK5RYsGN20 Feel free to reach me! #newPI #phdstudents #lacaixa
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