Martin Lauritzen
@MartinMlauritz
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🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧵
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The brain continuously generates metabolic water by glucose oxidation via mitochondrial activity in neurons This water contributes to brain fluid homeostasis, supporting nutrient transport and waste clearance. https://t.co/laCGe5XT3N
link.springer.com
Fluids and Barriers of the CNS - Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution,...
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The #TinyBrainsEU satellite workshop inaugurates this week's Mindlab course at @ICFOnians! Jennifer Lynch and Martin Lauritzen gave two keynote talks on diffuse optics for neuroprotection in congenital heart disease and transport regulation at the blood-brain barrier.
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Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes | Circulation Research
ahajournals.org
BACKGROUND: Microvascular complications are the major outcome of type 2 diabetes progression, and the underlying mechanism remains to be determined. METHODS: High-throughput RNA sequencing was...
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2/ Using the extensive 🐭 🧠#MICrONS Cortical MM^3 #ElectronMicroscopy dataset by @AllenInstitute, we found that about 20% of #microglia form direct contacts with #bloodvessels, bypassing the #astrocyteendfeet layer. We termed these contact points “plugs”. https://t.co/pBI3BOatOB
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1/ 🔥 Exciting findings from our collaboration between @UTAS_, @SeattleChildrens, and @uni_copenhagen! We've discovered a new way #microglia interact with 🧠 vasculature, which could reshape our understanding of their role in #brain health and disease. 🧵 https://t.co/iaNFHuURPg
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Jeg har nu blokeret Svinemosevej. Jeg flytter mig ikke før, vi får en CO2 afgift på landbruget!🙂 #dkpol #godweekend
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What would we be without collaterals….Very proud to share this. Big thanks to Nadine and Mohamad for amazing efforts+ all collaborators. @mohamad_elamki @snsf_ch @Unispital_USZ @UZH_ch @TanterM @franca_schmid @UZH_IPT
Blood vessels that cross-connect adjacent arteries prevent brain hemorrhage after removal of a blood clot. They are crucial for stroke patients to recover well. Thus, their function must be improved. https://t.co/hi8BG6q9ve
@SuseWegener @Unispital_USZ
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Anyone having luck using the acetylcholine sensor iAchSnFR in mice in vivo?
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Financial Times opinion writer weighs in on my Zlokovic investigation and related matters - 'There is a scientific fraud epidemic — and we are ignoring the cure' https://t.co/sdTLL3t5RQ via @ft @anjahuja
ft.com
Rooting out manipulation should not depend on dedicated amateurs who take personal legal risks for the greater good
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Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo | Journal of Neuroinflammation | Full Text
link.springer.com
Journal of Neuroinflammation - Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the interaction between oxidatively...
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Exceptional #2photon #fluorescence #imaging by Oleg Zhukov @Nai_Chiota from @transneuro_lab. You are looking at #adsorptive -mediated #transcytosis across the #bloodbrainbarrier in the #mouse #brain in #realtime #invivo. Perfect entry for a #FluorescenceFriday
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Delighted to share our take on the pivotal role of #vasculature in #adipose tissue biology in both health & disease: https://t.co/0nfRAkGeiq
@NatureRevEndo. Heartfelt thanks to @IbrahimAlZaim2, @rooij_laura, @BorgesonLab, & @Bilal_N_Sheikh for their invaluable contributions!✨
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LiddelowLab presentation in 30 minutes! I'll be giving a keynote about our decade-long goal to uncover reactive astrocyte sub-state functions. #Euroglia #glia2023 #gliameeting
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Human iPSC-derived brain #pericytes can replace lost pericytes - forming hybrid microvessels - and repair #BBB leaks in the living mouse brain! Is cell therapy the future of medicine for pericyte-deficient neurological disorders? Happy to see it out! https://t.co/6NnOc5HyGQ
biorxiv.org
Brain pericytes maintain blood-brain barrier (BBB), secrete neurotrophic factors and clear toxic proteins. Their loss in neurological disorders leads to BBB breakdown, neuronal dysfunction, and...
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What's the biggest mistake that I see pre-tenure assistant professors making? It looks like this: #AcademicTwitter #TenureTrack #AssistantProfessor #OnTrackforTenure
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REVIEW|Aitken et al. discuss the current understanding of how #endothelial cells sense #BloodFlow focusing on #mechanosensing and #mechanotransduction molecules and mechanisms. @EllieTzima @vedanta_mehta, @RDMOxford, @TheBHF| https://t.co/Of9Y6kyMsv 👉 https://t.co/qHANMgPgTw
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.@Caltech researchers including Dr. Viviana Gradinaru and @xinhong_chen evolved AAV9 capsids into vectors that transduce brain #endothelial cells following systemic administration in wild-type mice and rats. 🐁 🐀 Learn more about their research: 👉 https://t.co/cKgus0Qf39
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Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease | Nature Neuroscience
nature.com
Nature Neuroscience - Sun et al. analyzed 22,514 human brain vascular single-nucleus transcriptomes from 428 individuals and uncovered AD-related gene expression and cell–cell interaction...
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