Michael Webster
@WebsterMichael0
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Group Leader at the @JohnInnesCentre | Photosynthetic gene expression 🧬🌿 | Cryo-EM ❄️🔬.
Norwich, UK
Joined September 2012
How photosynthetic genes are transcribed 🧬🌿 I’m really pleased to share the first work from my group at @JohnInnesCentre published today in @CellCellPress: https://t.co/1GyoYtTIlg
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Super lucky to get the Faraday!@royalsociety Very grateful for the support from @JohnInnesCentre, @CarolineDeanLab, @DingLab_RNA, and all the collaborators/friends🙏 https://t.co/n14xIImUNU
jic.ac.uk
John Innes Centre group leader, Professor Yiliang Ding, has been awarded a prestigious Royal Society Faraday Discovery Fellowship…
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Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. https://t.co/6CItEE2X4d
#cryoEM #transcription #splicing
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Inspiring example of structural prediction + evolutionary conservation analysis by @amiralito_ in this thread 👇
🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14) https://t.co/54sR517kEP
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VACANCY - We have an exciting opportunity for a Cryo-electron Microscopy Support Specialist to join the Bioimaging Platform, collaborating with scientists at JIC and @NorwichResearch
https://t.co/5VBohC7Srp Closing date - 14 February 2025 Contract - Full-time, indefinite
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Please spread the word: we are looking for PhD students! Interested in supramolecular complexes in gene expression? Go to https://t.co/xMLfPjGxSh scroll down to “Integrated Structural Biology (LabEx INRT)” for project descriptions and start application process by January 19th!
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Also pleased to see evidence of the idea of increasing mRNA tension limiting translation as the machineries approach. An intricate mechanism to avoid molecular collisions 💥
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Really pleased to see this study of gene expression coupling performed so comprehensively! When we determined structures of ribosome-polymerase complexes we knew were seeing the tip of the iceberg- static moments of two machines that should be seen moving. Congratulations!
First paper of our lab today @Nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl
https://t.co/ui1h01VaQW
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Beautiful cryo-EM reconstructions from our lab neighbour. Delighted to see it out 👇🔬❄️🧬
Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date). @JohnInnesCentre @DurhamU34989 @MCB_UJ
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In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics? https://t.co/r6jLzkFjOO
eurekalert.org
An international team of scientists have used advanced microscopy to image how ribosomes recruit to mRNA.
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From #cryoEM to #singlemolecule kinetics https://t.co/7ufYwuTHtu So proud and humble to share this work alongside @WebsterMichael0 and one of my scientific hero @AlbertW_Lab This is how I envision Science and Collaboration at its best. @NilsWalterLab
science.org
Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the...
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🌱 Exciting opportunity in the Jarvis Lab @OxfordBiology! We're hiring a 3-year Research Assistant to study the structure & function of the plant chloroplast protein import machinery. 🔬 Help us resolve the structure of the TOC-TIC translocon! Apply here: https://t.co/SEMSRC6nGg
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We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: https://t.co/Ni4nJGJAug The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7
science.org
Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the...
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PRESS RELEASE - Delivery mechanism discovery resolves gene expression puzzle International research collaboration has used advanced microscopy to capture in unprecedented detail a critical moment in gene expression. https://t.co/EiqDo9sJMx
@NorwichResearch @WebsterMichael0
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Joe Ecker @JoeEcker, Joseph Swift @_joseph_swift, and team have revealed the genetic details of 30-million-year-old question: How did some plants evolve from less-efficient C3 photosynthesis to C4 photosynthesis? Their findings pave the way for the creation of more robust,
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A few more days to apply 👇 Hopefully an exciting project for a student interested in cryo-EM, biochemistry, biophysics and plants 🪴
We are looking for a PhD student to lead a project in the lab focused on the gene expression mechanisms supporting Rubisco production in plants 🌿🧬👇 Please share and contact me if you'd like to know more.
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We are excited to announce the launch of our MSc in Microbiology, and I will be serving as the Program Director for the next academic year. Please feel free to reach out if you would like to learn more about this exciting opportunity. @biouea
https://t.co/bRtA6Sgd17
uea.ac.uk
Study our MSc Microbiology degree and learn the core concepts and broader societal impacts in the function of microorganisms supported by research resources.
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VACANCY - We're recruiting a Director to lead our world-renowned, independent, international centre of excellence in plant science, genetics and microbiology. Please share and apply: https://t.co/3jX2cwe6aZ Closing date - 22 November 2024 @NorwichResearch
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Great to see this #cryoEM collaboration between @JohnInnesCentre and @TheSainsburyLab out in its final form. Take a look if you're interested in the fascinating world of plant immunity structural biology.
So happy to see the final version of our paper on the structure of the sensor-activated NRC2 hexamer online! Congrats to @JMadhuprakash and the whole team 👏 Check out Madhu's and @amiralito_'s threads below for the key highlights 👇🧵 https://t.co/oCagLFh8kL
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We have an open #postdoc position to study the molecular mechanisms of #DNArepair !🧬🔬 The project will build on recent findings https://t.co/TDxCrkgZKb and established collaborations, using #cryoEM and #SingleMolecule imaging. Access to fantastic facilities @MRC_LMB .
nature.com
Nature - FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the...
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