Tim Springer Lab
@TimSpringerLab
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Structural Biology. Immunology. Integrins. TGF-beta/BMP. Lab account for PI: @timothyspringer.
Boston, MA
Joined December 2013
📣 The Springer Lab is hiring! Advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology. https://t.co/y8G4xKeLuI
#postdocjobs, #academictwitter, #ECRchat, #phdchat
timothyspringer.org
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We’ve joined Bluesky! Follow the Springer Lab (@springerlab.bsky.social) for insights into integrin and TGF-β signaling, mechanobiology, organoids and regenerative medicine, and structural biology. #Integrins #StructuralBiology #Biophysics #Organoids #RegenerativeMedicine
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A new @nature #cryoEM study on #SARS-CoV-2 details the postfusion spike in a #lipidbilayer, defining the structure of critical membrane-interacting segments that may guide intervention strategies From researchers @ipiproteins @harvardmed & more ⬇️ https://t.co/GbUIpoAwa2
nature.com
Nature - The SARS-CoV-2 spike internal fusion peptide forms a hairpin-like wedge that spans almost the entire lipid bilayer and the transmembrane segment wraps around the fusion peptide at the last...
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Thanks @ipiproteins for sharing our work!
From Viet Le & @timothyspringer of @timspringerlab @harvardmed @BostonChildrens: #Integrin αVβ6 has a specific & unappreciated role in #TGF-β2 activation, unlike the αVβ8-driven activation of TGF-β1/β3 & with big implications for fibrosis drug development https://t.co/PCLYNCAQxB
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@harvardmed @Stanford @UniofOxford @deboramarks @Harvard @UZH_en @osaka_univ_e Hear a panel on synthetic #antibodies & #OpenScience 👇 🧪Errik Anderson, @AlloyTx 🧪@aledmedwards, @thesgconline & @UofT 🧪Andrew Kruse, @harvardmed 🧪Rob Meijers, IPI #Antibody Platform director 🧪Andreas Plückthun, @UZH_en 🧪Meghan Rego, @Addgene
https://t.co/llg7fZjOHR
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Don't forget! Join IPI Surfacing tomorrow at @harvardmed. Networking, discussion, posters & talks👇 🧪Christopher Garcia, @Stanford 🧪Yvonne Jones, @UniofOxford 🧪@deboramarks, @Harvard 🧪Andreas Plückthun, @UZH_en 🧪Junichi Takagi, @osaka_univ_e
https://t.co/llg7fZjOHR
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A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8
pubmed.ncbi.nlm.nih.gov
Activation of latent transforming growth factor (TGF)-β2 is incompletely understood. Unlike TGF-β1 and β3, the TGF-β2 prodomain lacks a seven-residue RGDLXX (L/I) integrin-recognition motif and is...
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Proteins need to breathe: Stabilising conformations in a #malaria #parasite surface protein stops #Plasmodium #sporozoite migration and blocks transmission. Our latest collaboration with @TimSpringerLab out @emboreports. 'Fixing' TRAP 'kills' the parasite. https://t.co/gI613amWun
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Transforming growth factor (TGFß) is key regulator: immune system, development. There are 3 TGFß's; 1,2,3. Springer @BostonChildrens @HarvardMed use @ATUM_bio constructs. Show TGFß2 is activated by separate integrin. New opportunities for treating fibrosis
pnas.org
Activation of latent transforming growth factor (TGF)-β2 is incompletely understood. Unlike TGF-β1 and β3, the TGF-β2 prodomain lacks a seven-resid...
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🎉 IPI has partnered with @Addgene to provide biomedical researchers worldwide with access to well-validated #antibodies and other reagents, and expertise on how to use them. Look out for our release of a set of #integrin antibodies this fall! Read more: https://t.co/rurFopgAOW
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Recent research by @MyungHyunJO1 @taekjip @XuefengWang11 @timspringerlab & @ipiproteins shows exactly how #integrins harness chemical cues and respond to physical forces. Curious how it works? Read more here 👇 https://t.co/JxRsizQdk5
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Tim Springer is focused on his existing roster of commitments — running a research laboratory of more than a dozen people @TimSpringerLab, overseeing three NIH grants and sitting on six boards, including @SelectaBio, @MorphicTx, @TectonicTx and @Seismic_Tx
https://t.co/l2qndcntHW
endpoints.news
Tim Springer, with his name stapled to the likes of Moderna, Scholar Rock and Editas Medicine, plus the foundational work for Takeda’s ulcerative colitis and Crohn’s disease med Entyvio ...
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@timothyspringer @LaskerFDN With Richard Hynes & Erkki Ruoslahti, Springer discovered integrins, cell surface proteins that enable cells to interact with their surroundings Today, IPI is creating antibodies that can bind to integrins to accelerate #basicresearch and #drugdiscovery
https://t.co/POy2fKVGMT
proteininnovation.org
More than 600 million years ago, out of the depths of the metazoa, a protein family emerged — one that would persist through evolution and come to shape
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Acceptance remarks from @LaskerFDN #LaskerAward winners Richard Hynes, Erkki Ruoslahti, and @timothyspringer for their discoveries concerning #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease:
laskerfoundation.org
Explore All 2022 Winners & Awards > Richard O. Hynes Massachusetts Institute of Technology Erkki Ruoslahti Sanford Burnham Prebys Timothy A. Springer Boston Children’s Hospital/Harvard Medical School...
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Congratulations Richard O. Hynes, Erkki Ruoslahti, and Timothy A. Springer, 2022 #LaskerAward winners! — “for discoveries concerning the #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease”. @MIT @sbpdiscovery @harvardmed
#Lasker2022
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2 Boston-area scientists win prestigious Lasker Awards for cell research - discovery of integrins. @TimSpringerLab & Richard Hynes. https://t.co/7aWj3QEiaB via @BostonGlobe
bostonglobe.com
Two Boston-area researchers are among the winners of prestigious Lasker Awards for their discoveries concerning integrins, proteins on the surface of cells that help them attach to other cells as...
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At @BiophysicalSoc's #bps2022 this week, @IPI_Protein co-founder @timothyspringer was awarded the 2022 Founder's Award for his innovations in #immunology, including his work on #integrins. Congratulations, Tim and @TimSpringerLab! 🎉 Story:
biophysics.org
ROCKVILLE, MD – The Biophysical Society is pleased to announce that Timothy A. Springer, PhD, of Harvard Medical School and Boston Children’s Hospital will receive the Society’s...
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Interested in growth factor latency? Here a comparative survey of cross-armed, V-armed, and open-armed TGF-β family members from @TimSpringerLab Protection of the prodomain α1-helix correlates with latency in the tr...
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Wesley Wong and Tim Springer’s labs use single-molecule imaging to explain how von Willeband factor is able to self-associate to enable its key function in blood clotting. @WesleyWongLab @TimSpringerLab
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@TimSpringerLab - Congrats to Tim Springer who will receive the 2022 Founders Award from the Biophysical Society!
biophysics.org
The Biophysical Society is pleased to recognize the following 2022 award recipients. These members will be honored during the 66th Annual Meeting in February. Patricia Bassereau, Institut...
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