Jon Humphries
@JDHL18
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Bioscience, Manchester Metropolitan University. Cell adhesion, proteomics, ECM. Tweets (not posts) mainly science.
Manchester UK
Joined October 2009
Very belatedly I've decided to pause posting here. You can find me and my posts where the skies are blue...
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It's a New Year but the signs of melanoma skin cancer are the same. 📆 Make monthly skin checks one of your 2025 resolutions and get to know the signs. 🔎 Skin & Nail Check Leaflet 👉 https://t.co/Vn9kT83hAp
#melanoma #signsofskincancer #skincancersigns
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#PLOSONE: THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes p ...
journals.plos.org
RNA-modifying enzymes have recently garnered considerable attention due to their relevance in cancer biology, identifying them as potential targets for novel therapeutic intervention. THUMPD3 was...
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Targeting extracellular matrix stiffness for cancer therapy https://t.co/NsRSdzPBtz
frontiersin.org
The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. A...
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FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling
biorxiv.org
Atherosclerosis develops at predictable sites in the vasculature where branch points and curvatures create non-laminar disturbed flow. This disturbed flow causes vascular inflammation by increased...
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FAK and p130Cas Modulate Stiffness-Mediated Early Transcription and Cellular Metabolism https://t.co/2Pv07GULj3
onlinelibrary.wiley.com
Cellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate...
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ITGB4-Related pyloric atresia without epidermolysis in two siblings
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Emergence of the cell-matrix adhesion element ILK as a player in glioblastoma cell plasticity.
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Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice https://t.co/AKcNKib2fv
nature.com
Nature Communications - The mechanisms regulating multipotency in glandular epithelia remain unclear. Here, the authors identify the key role of collagen signaling and ECM stiffness in regulating...
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Review Integrins as Drug Targets in Vascular and Related Diseases https://t.co/s2TRgMZiEH
sciltp.com
Integrins are transmembrane receptors that, as critical participants in a vast range of pathological processes, are potential therapeutic targets. However, in only a few cases has the promise been...
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JCI Insight - Talin1 dysfunction is genetically linked to systemic capillary leak syndrome
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The kinesin KIF3AC recycles endocytosed integrin to polarize adhesion formation towards the leading edge
biorxiv.org
The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this...
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This week the Guardian's owner, the Scott Trust, gifted the 233-year-old Observer to Tortoise Media. This isn't just a dark day for journalism, it's a sign. Meet the team. This is Putin giving Tortoise's energy advisory board member an 'Order of Friendship' medal in 2017. 1/
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FAK inhibition suppresses breast cancer progression via DNA methylation-mediated DAB2 gene reactivation
biorxiv.org
Epigenetic silencing of tumor suppressor genes is one of the main drivers of tumor progression. Without these tumor suppressors to reduce proliferation, tumor cells proliferate unchecked. Focal...
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It's a busy time of the year but don't put off checking your skin! Getting to know your skin & monitoring any changes, lesions & moles can help you spot the early signs of skin cancer. If you are concerned about a mole or lesion, please contact your GP. https://t.co/Vn9kT83hAp
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Sending our best wishes to @JulianLennon at this time. Thank you for using your platform to raise vital awareness and highlighting the importance of regularly checking your skin. About melanoma: https://t.co/lfd6nLSsDb FREE skin and nail check leaflet:
🫣 Disturbing Images…. Hi Folks, Well, here’s how this goes… Before I flew to New York from Los Angeles, for good morning America , Sirius XM, iHeart Radio & My Fotografiska Q&A Book Signing Event, I went to see, as I usually do when in LA, My lovely Dermatologist - Dr Tess,
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Our study recruiting now! Using ctdna to guide whether to have systemic treatment in early stage melanoma - amazing response from UK to get this q addressed- we already have 7 sites open in the first month and our first patient randomised! @CR_UK funded 🎉🎉
The Detection-2 feasibility study is now open looking at using a ctDNA blood test to guide treatment for patients with high-risk stage 2B/2C/3A cutaneous melanoma who have had surgery to remove it. It will be open for 1year in at least 8centres across the UK
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The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness
biorxiv.org
Background Cells are constantly sensing and responding to changes in their local environment to adapt their behaviour and morphology. These external stimuli include chemical and mechanical signals,...
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Why probability probably doesn’t exist (but it is useful to act like it does)
nature.com
Nature - All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
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