Peggy Hsu MD PhD
@PeggyPHsu
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Oncologist-scientist @UMRogelCancer | Lung cancer, ALK, organoids, cell fate, metabolism
Ann Arbor, MI
Joined July 2017
Hard to compete with the Nobel prizes (!!!) today but proud to share our preprint (by a fun team of @TheSpenceLab, Ansley Conchola, Tristan Frum + many others) where we present a cellularly-resolved map of the developing human lung, identifying a human-specific LGR5+ basal cell.
Excited to share our latest preprint: . A spatially-resolved blueprint of the developing human lung reveals a WNT-driven niche for basal stem cells. Led by a talented team: @PeggyPHsu, Tristan Frum and Ansley Conchola - and with many other contributors!
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RT @lcrf_org: World Lung Cancer Day is coming up on August 1! . We are raising awareness and standing with everyone impacted—because lung c….
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RT @GrayCampLab: Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organo….
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RT @chivukula_raghu: Why do some genetic mutations devastate specific tissues while sparing others?. We explore this question in GGC repeat….
science.org
Aggregation-prone polyglycine-containing proteins produced from expanded GGC repeats are implicated in an emerging family of neurodegenerative disorders. In this study, we showed that polyglycine...
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RT @KatajistoLab: Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Pan….
nature.com
Nature Metabolism - Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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RT @HelenBranswell: Valuable cell lines that are key to research are being sold at bargain basement prices as the California Institute for….
statnews.com
The California Institute for Regenerative Medicine and its partners are selling thousands of stem cell samples before many of them are discarded.
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RT @lcrf_org: Several of LCRF's staff visited the University of Michigan this week to tour Dr. Peggy Hsu’s lab and enhance the broader ALK….
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RT @ALKPositiveinc: Attending the 2025 ALK+ Summit? 💉 Be part of groundbreaking research!. Join the blood draw & support the Judith Tam @UM….
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RT @CellReports: Lysophosphatidic acid and sphingosine-1-phosphate are apical polarity cues in multiple organoid systems .
cell.com
Tidball et al. reveal that LPA and S1P induce apical-out epithelial orientation in brain, lung, and intestinal organoids through GPCR/RhoA signaling. These phospholipids, present in biological fluids...
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RT @ALKPositiveinc: About 70K people in the U.S. are living with ALK+ lung cancer—most diagnosed at Stage IV. 🎯 Early detection + targeted….
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So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way!. BWF Announces 2025 Career Awards for Medical Scientists
bwfund.org
The Burroughs Wellcome Fund is pleased to announce the recipients of the 2025 Career Awards for Medical Scientists (CAMS). This award supports early-career physician-scientists as they transition...
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RT @LUNGevity: Mesenchymal (vimentin+) circulating tumor cells (#CTCs) may be progostic for progression in ALK+ #NSCLC. Great to see more n….
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RT @JasonRCantor: 🚨 pleased to share a new preprint made possible through a great collaboration with the @melissa_skala & @SeanPalecek labs….
biorxiv.org
Maturing human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in vitro is critical for advancing drug discovery and cardiotoxicity screening applications of these cells. However, the...
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RT @LyssiotisLab: 🔥Smoking hot new paper and tweetorial from @DJCalebC (collab with @ArulChinnaiyan)! 🔥. We are over the moon about this ne….
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RT @UMRogelCancer: A seed grant from the Forbes Institute for Cancer Discovery helped @NagrathSunitha explore a provocative idea: why were….
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RT @DelgoffeLab: New work from the group is now ONLINE at @NatureCellBio! Originally tweet-threaded here: https://….
nature.com
Nature Cell Biology - Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by...
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RT @HerediaOncologo: Not all Lung adenocarcinomas (LUAD) respond the same. 📊Mucinous LUAD = 10% of cases, often KRAS+, TTF1–, PD-L1 low.Wor….
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RT @DanaFarberNews: Congratulations to Matthew Meyerson, MD, PhD, FAACR, @DrChoueiri, and Alice T. Shaw, MD, PhD, recipients of @AACR 2025….
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RT @ALKPositiveinc: What if a leukemia drug could help treat ALK+ lung cancer?. A new trial at @UMRogelCancerCtr is exploring gilteritinib—….
alkpositive.org
This trial is for patients with Stage 4 ALK positive NSCLC that have progressed on an earlier generation ALK TKI AND lorlatinib, and on any number of other standard-of-care or trial treatments. The...
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RT @BrandonTWChen: Happy to share our most recent review on mitochondria-organelle metabolic communication with @YatrikShahLab and @Lyssiot….
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