Terence Capellini
@TDCapellini
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Professor of Human Evolutionary Biology at Harvard University studying the evolutionary genetics of the human body and human adaptations
Cambridge, MA
Joined June 2017
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I got tenure and am on cloud 9! This is not a personal feat but a team effort & I want to thank my present/past lab
@DanRichardBio
@gk_senevirathne
@CoveneyClarissa
A. Okamoto,
@EvvieJagoda
@MarielBYoung
@dingwallaby
@m_pushpanathan
, Z.Liu & my collaborators for their support. :)
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1) Regarding tail loss paper (),
@BoXia7
,
@ItaiYanai
,
@JefBoekeI
, I have the following thoughts, that maybe should be presented as scenarios. Hopefully, the scenarios and additional comments invoke discussion in the community:
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I am giving a special
@Harvard
and
@HarvardHEB
presentation (aka my Tenure Talk) on September 9th at 3:30pm (EDT). If anyone wants to watch please contact mmccoy
@fas
.harvard.edu for the zoom link.
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Pleased to see our paper out at Cell. Congrats to collaborators:
@akiapour
@vkola_lab
@m_pushpanathan
@evelynjagoda
@MarielBYoung
and others.
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk
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1/13. In Young et al we explore the evolutionary adaptations of our unique human pelvic structure using morphometrics, embryonic development, transcriptomics, epigenomics, and comparative genomics.
#ScienceResearch
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1/10. Pleased to see our latest work by the awesome
@evelynjagoda
and Davide Marnetto is out in
@eLife
on identifying causal variants at a major COVID-19 risk locus introgressed from Neandertals and under adaptive evolution in humans.
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Congrats to my amazing undergrad student Naomi Freilich, graduating Summa with highest honors and a 4.0 GPA at Harvard. She wrote a remarkable honors thesis on the developmental evolution of the human pelvis
@HarvardHEB
couldn’t be prouder!!!!
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Please retweet widely: My department
@HarvardHEB
is conducting a search for an Assistant Professor in the area of Human Evolutionary Genetics and Genomics. Please see the information at the link below and reach out to me if you have any questions:
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Currently for my department (HEB), I am Acting Department Chair, Director of Graduate Studies, Search Committee Chair, Graduate Admissions Chair. All I need to be is Director of Undergraduate Studies and I will have all the power to mess everything up (accidentally) big time!
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Big shout out of THANKS to
@TamaraAlliston
and
@defratelab
for their remarkable work and creativity in putting together the
#MSKGordon2022
conference in NH. That was my favorite conference of all time! Such as great group of scientists!!!! Thanks!!!!!!!!!
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Just submitted tenure materials - now the long waiting game until next year and the push to get more exciting out!
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@HarveyGiroux
@huh23100
@MapleLeafs
1-0 loss in a series called the conference finals. You have to win other series to get there…you probably wouldn’t understand
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Congratulations to Dr. Evelyn Jagoda
@evelynjagoda
! You performed brilliantly today during your Dissertation Defense. You never cease to amaze me!
@HarvardHEBgrads
@PardisSabeti
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Congrats to my post-doc
@CoveneyClarissa
for winning best poster award at the MGH Center for Skeletal Research Symposium for her work on activating/repressing domains at the GDF5 locus! Hard work and brilliance pays off!!!!
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Check out this preprint from my student
@okamotoevodevo
on using mammal genotypes, phenotypes, & GWAS data to examine parallel evolution in regulatory regions. Thoughts, comments are welcome as we are working on techniques to explore this intersection:
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A BIG THANK YOU to all of you who were able to attend my tenure talk today, it was nice to see you in attendance and felt nice to get the support. You all rock!!!!
I am giving a special
@Harvard
and
@HarvardHEB
presentation (aka my Tenure Talk) on September 9th at 3:30pm (EDT). If anyone wants to watch please contact mmccoy
@fas
.harvard.edu for the zoom link.
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A huge shout out of CONGRATULATIONS to my student Dr. Daniel Richard
@DanRichardBio
at
@HarvardHEB
for successfully and brilliantly passing his PhD Dissertation Defense! Amazing!!!!!!
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BIG THANKS to
@RebeccaJFerrell
, the
#NSF
and its reviewers for awarding
@evelynjagoda
and I a grant to explore Neandertal genetics. Thanks to our collaborators:
@sr_sankararaman
@MichaDannemann
@jfkelso
luca pagani
@emiliahsc
@PardisSabeti
@ReillyLikesIt
and others
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Want to learn about bones, joints, development, human evolution, and Neanderthals, the Capellini Lab
@harvard
has a post-doc position available to fill ASAP? Please email
@TDCapellini
for information and visit:
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If you are interested in hearing about the evolutionary developmental genetics of the human pelvis, my wonderful student
@marielBYoung
defends her dissertation in a public talk tomorrow at 10am EDT. Message or email me for a zoom link.
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A want to give a big shout out to my former student
@DanRichardBio
who received his doctoral degree last Thursday! Congratulations again!!! Daniel is a remarkable scientist, who is now a post-doc with Dr. Anne Brunet at Stanford.
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Interested in the developmental genetic basis of skeletal variation and disease risk in humans and primates, my lab is accepting applications for graduate students to start Fall 2021. See: and . Contact Terence Capellini.
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I stand against the recent, hatred acts targeting my LGBTQ+ students, staff, and faculty colleagues at
@Harvard
. Attacks against them are attacks against us all. Such attacks do not intimidate us but only bring us closer together and our need to push for further reform.
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8) An alternative scenario is that the tail already was lost and this Alu and its exon-skipping function was permitted under relaxed selection? This remains unknown but is related to how this gene was chosen out of many potentially effective ones.
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For Any Interested:
On 3/2 we will host the free
#HybridLecture
"When
#Evolution
Hurts." Terence D. Capellini, Prof.
@HarvardHEB
, will discuss the research that is helping scientists better understand the relationship between bipedalism and
#knee
#osteoarthritis
. Sign-up: .
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Genetics Genomics community: Can you send me links to articles demonstrating in vivo (or in vitro) functional validation of single base-pair non-coding variants with important links to disease via GWAS?
@GeneticsGSA
@GeneticsSociety
@eshgsociety
@AAAgenetics
@GWAS_lit
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From noon to 2pm today come see terrific work by
@evelynjagoda
“Investigating the Phenotypic Consequences of Archaic Hominin Introgression on Modern Human Biology” main poster hall
#aapa2019
#neanderthals
#genopheno
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Please Retweet: In one week
@HarvardHEB
is having their 2022 Open House for prospective PhD students: . Please register but you can message
@TDCapellini
if you want to zoom link. Lots of fun will be had by all those who attend!!!
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Post-doc opportunity in the Capellini Lab. Please inquire by visiting and then emailing me using the address provided.
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Ridiculous: R01 goes from 36 percentile to 13 percentile (just on the cusp, payline was 12 percentile) to have it go back up to 30 percentile and after ADDRESSING ALL CONCERNS and using more refined approaches.
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Popular coverage of our work on the human pelvis in the Harvard Gazette with
@MarielBYoung
@DanRichardBio
@markwgrabowski
@KristiLewton
@m_pushpanathan
and so many wonderful colleagues:
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Happy to announce our new work in
@ScienceAdvances
by Young et al. on the evolution of the human pelvis.
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Please retweet widely: If you're interested in human skeletal development, evolution, disease, I plan to accept graduate students into my lab at
@HarvardHEB
, Fall 2022. Please visit HEB's website - & my website -. Emails work too!
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Huge Congratulations to Dr. Mariel Young
@MarielBYoung
- You did a superb job today defending your dissertation and you gave a beautiful presentation on your developmental genetic work! I am so very proud of you! Thanks to all that could attend!
@HarvardHEBgrads
@HarvardHEB
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@ItaiYanai
I do hope that my posts were not disparaging in any way. I hope to engage with you and your team to talk about the interesting science you conducted.
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A very big shout out to Dr. Min Ya (
@0_minyaaa
) who performed absolutely brilliantly today during her Dissertation Defense. Min Ya, your presentation was one for the ages!!! Congratulations!
@HarvardOEB
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Excited to announce that tonight at 8pm on CBS is
#Survivor41
featuring my former graduate student Evvie
@evelynjagoda
, who also is a rock-star that just defended last month! I've never watched the show but will tonight!!!! GO EVVIE!
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My department, Human Evolutionary Biology at Harvard University, has a new Tenure-Track position. Please see the advertisement below. Please retweet broadly. Thanks!
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To keep yesterday's excitement rolling: Congratulations and a Huge Thanks to Svante and this truly remarkable accomplishment. My own science and that of my department
@HarvardHEB
has been transformed by your discoveries!
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Terrific review my my colleagues
@DanRichardBio
and
@Diekman_Lab
!
New from
@Diekman_Lab
&
@TDCapellini
in
@AJPCellPhys
!
#Epigenetics
as a mediator of genetic risk in
#osteoarthritis
: role during development, homeostasis, aging & disease progression (Richard et al.)
#Genetics
#GWAS
@HarvardHEB
@NCState
@UNCTARC
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A big big THANK YOU to the The Musculoskeletal Research Center at WashU and all of the terrific faculty and trainees for the invitation to give a seminar today! I had a terrific time and am in awe of the amazing research going there!!!
@mfarooqrai
@Farsh_G
@WUSTLmed
@WUSTL
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I would like to give a big shout out to my student Heather
@dingwallaby
, who today successfully defended her dissertation on the "Developmental Genetics of Tendon Growth." Heather is now officially Dr. Dingwall! Congrats! This is entirely well deserved and awesome!
@HarvardHEB
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So excited to see this work out by my post-doc Daniel Richard in collaboration with April Craft's lab at BCH. Such cool work! Congrats
1/7. Excited to have this excellent work done with the Craft Lab at BCH,
@divyav97
,
@RMRaftery
and
@TDCapellini
out in
@eLife
! We performed a deep-dive characterization of regulatory networks active in developing chondrocyte lineages
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Lab is on the edge of being shut down and for a long, long while. My lab ppl are wonderful! Big shouts out to
@evelynjagoda
@m_pushpanathan
and
@MarielBYoung
for their efforts these past three days. We will all now hunker down and analyze datasets and write to our hearts content.
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Please see our recent research on complex disease risk and enhancer specificity. With
@akiapour
@SpringerNature
@NatureComms
#Genetics
#Skeleton
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Sign-up for the 2022 GRC & GRS for Musculoskeletal Biology and Bioengineering! 8/7-8/12/2022:
Students & Post-docs should sign up for the GRS, 8/6-7.
It will be terrific and is led by the wonderful
@TamaraAlliston
&
@defratelab
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See this terrific piece on our recent work in Nature Communications! Thanks Nancy!!!!! Looks wonderful!
Two separate gene
#enhancers
, both acting on GDF5, have effects specific to the hip and knee and are linked with #
#hipdysplasia
and knee osteoarthritis, respectively. A great ‘joint’ project co-led by
@akiapour
&
@TDCapellini
:
#orthopedics
#genomics
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Please Retweet:
@HarvardHEB
is having an Open House for prospective PhD students: . See registration form.
@BlackinBioAnth
@Questbridge
@ImFirstGen
@LEDA_Scholars
@TheJKCF
@ReachHigher
@FirstGenCenter
@HSFNews
@CokeScholars
@TheTalentEDProj
@LavidaScholars
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Simply a terrific
#BonesAndTeethGRC
@GordonConf
. Huge thanks to Chair
@eschipani19
and VC Charles O’Brien for organizing this conference.
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Awesome job by
@GrainOfScience
and
@danielle_rux
on organizing a terrific
#GRS
Program in Italy! Thanks!!!!!
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Things are moving fast - setting up by this weekend to essentially close the lab for 6-8 weeks. Definitely the right thing to do - thankfully students have most of their large -seq datasets to process and experiments completed! Good luck to all those doing the same!
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Big shout out to
@SLoopmans
and
@clairearataphd
for running a wonderful
@GordonConf
#BonesAndTeeth
Congrats!
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Senator Chris Murphy says it best: "Why do you spend all of this time running for the US senate....of putting yourself in a position of authority...if your answer...as our kids run for their lives, we do nothing."
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Looking forward to this talk! Thanks to the organizers for inviting me!
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We have a faculty position at
@HarvardHEB
- please check out the link!
Harvard's Department of Human Evolutionary Biology (HEB) is looking for someone who applies evolutionary theory to understand human biology (open level). Expertise may include physiology, anatomy, paleoanthropology, life history, neurobiology and other areas.
@HarvardHEB
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I want to wish Pushpanathan (
@m_pushpanathan
) the very best of luck in his next adventure in California! You have been a terrific Post-Doctoral Fellow in my lab. You have also been a great mentor to many undergrads in the lab. I am eternally grateful for all of your contributions
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tonight at 6pm for anyone interested...follow link to register.
On 3/2 we will host the free
#HybridLecture
"When
#Evolution
Hurts." Terence D. Capellini, Prof.
@HarvardHEB
, will discuss the research that is helping scientists better understand the relationship between bipedalism and
#knee
#osteoarthritis
. Sign-up: .
1
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Please retweet broadly: The Human Evolutionary Biology at Harvard has a College Fellow position with a deadline of May 23rd. This is an excellent opportunity for Ph.Ds interested in teaching and research. Please see link below:
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Please see the Harvard Gazette piece on our recent work on joint biology in Nature Communications () with
@akiapour
@m_pushpanathan
and many others:
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Check out Nature Genetics
@TDCapellini
aka: When evolution hurts: height, arthritis and gene regulation
#Science
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Today we released our latest work on the intronic cis-regulation of ACE2, a major receptor for SARS-CoV-2. Great/fun collaboration with
@DanRichardBio
@m_pushpanathan
@ACDoxey
@sci_questions
@jeremyhirota
, Karen Mossman and Jennifer Aguiar
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The Capellini Lab is excited to have Dr. Sarah Rice (
@GrainOfScience
) visit the lab for two weeks to talk shop, present her science, and learn protocols! We hope she has a safe journey to the States.
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I had a wonderful time today presenting my lab's research from
@HarvardHEB
at the
@USCStemCell
seminar series. The meetings with trainees and faculty were great. What a terrific community of scientists! Thanks to Gage Crump and Andrew McMahon for hosting and inviting me!
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Big shout out to
@MarielBYoung
and my colleagues on our new work on the pelvis in
#ScienceResearch
#ScienceAdvancesResearch
1/13. In Young et al we explore the evolutionary adaptations of our unique human pelvic structure using morphometrics, embryonic development, transcriptomics, epigenomics, and comparative genomics.
#ScienceResearch
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1/12 Our recently accepted paper led by
@m_pushpanathan
is out on the genetic causes on musculoskeletal diseases, most notably hip dysplasia and knee osteoarthritis. You can find it at this link: Great collaboration with
@akiapour
,
@DanRichardBio
others.
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I am excited to invite you to attend my graduate student
@evelynjagoda
Dissertation Defense on understanding the biological impacts of Neanderthal adaptive Introgression in humans on Aug. 3rd at 9am EST at link below. Message me with questions.
@harvardHEB
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This morning at 9am (EST), my awesome graduate student
@evelynjagoda
will give her Dissertation Defense on understanding the biological impacts of Neanderthal adaptive Introgression in humans at the link below. Message me with questions.
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Looking forward to the
#MSKGordon2022
this coming week in NH. Can't wait to see many of my colleagues!
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Recent coverage on our paper on the human pelvis is out (with
@MarielBYoung
@DanRichardBio
@markwgrabowski
@anthrokurki
,
@m_pushpanathan
,
@LiaBetti
,
@KristiLewton
,
@LJBirkenstock
, Benjamin Auerbach, Bernadette S. de Bakker, Jaco Hagoort, Vismaya Kharkar)
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Great Post-doc opportunity in my collaborator April Craft's lab at Boston Children's Hospital. Postdoctoral positions in pediatric cartilage disease modeling and gene regulatory networks governing human skeletal lineage commitment using iPSCs.
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Today members of Harvard University received a hate-filled, racist email threatening African Americans from Equity Prime Mortgage, which had its email hacked. I stand with my African-American colleagues in their constant support and to say that this will not be tolerated! BLM!
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Excited to present tomorrow at this wonderful event! Thanks for the invitation!
Join us tomorrow at 1700 GMT to learn more about the development and evolution of the human pelvis with
@HarvardHEB
Professor
@TDCapellini
! All are welcome, click the link below!
#HumanEvolution
#Biology
#Genetics
#SciComm
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I am glad that Biden recognized the Armenian massacre as genocide. Now, he needs to recognize that the Native American massacre in the US was also genocide. The policies used by our fledgling country were deliberate and had an end goal to justify expansion.
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Please retweet widely:
My department
@HarvardHEB
is hiring at the Tenure-Track Assistant Professor level in the area of Human Diversity. Please see Ad below:
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@FondaJLee
When you write as well as Tolkien, well then maybe, just maybe, you'll deserve a shelf. Until then, dwell on the fact that Tolkien paved the road for this genre, and likely inspired many to take the chance to read your drivel.
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Excited for my student
@evelynjagoda
to be attending
#humanevol19
and presenting her excellent work on the use of a high throughput functional screen to interrogate Neandertal introgressed variants!!!! Thanks
@wellcomegenome
for hosting and providing the terrific venue!!!
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1/7 Terrific work by graduate student
@DanRichardBio
@HarvardHEB
on the relationship between epigenetics, evolution, aging, & disease risk.
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Recent work on ACE2 cis-regulation from my lab by Daniel Richard and
@m_pushpanathan
in collaboration with
@sci_questions
@ACDoxey
Jeremy Hirota, Karen Mossman, and Jennifer Aguiar
is now on bioRvix.
Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways
#bioRxiv
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4
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Our new review on the biological mechanisms underlying height variation is out. Thanks to
@Graham_Coop
and Peter Visscher for helpful discussions:
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Big shout out of congrats to
@UCSDCooperLab
Adi Saxena and collaborators; Virag Sharma
@hillermich
@m_pushpanathan
@StanleyNeufeld
@CalgaryCobb
for this terrific work!!! We were so happy to take part in it and work with you!
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Below is the exact line that
#isles
fans should remember when thinking about Pajama Boy:
When asked directly by the Maven why his move to the Maple Leafs couldn't be done before the trade line:
"I didn't want to come to a team and feel like the team had to subtract what they had"
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Looking forward to meeting colleagues
@SerenaTucci
and others at
@Yale_Anthro
, and giving their Brown Beer talk at 5pm! Thanks for the invitation!!!!
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Check out our new paper (
@TDCapellini
) on GDF5 regulation during knee development and homeostasis in the Annals of the Rheumatic Diseases:
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Excellent coverage of our work with
@markwgrabowski
@MarielBYoung
and many other researchers!
Genes reveal how our pelvis evolved for upright walking and childbirth
@ScienceAdvances
@ScienceMagazine
@ljmubiology
@LJMUResearch
@markwgrabowski
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Terrific scientist! So happy for him. Congrats!
I could not be more delighted that my mentor Dr. Henry Kronenberg will receive
@TheEndoSociety
Fred Conrad Koch Award.
Dr. Kronenberg's contributions to bone endocrinology are legendary. More importantly, his mentorship has launched the careers of countless endocrinologists.
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I heard today the following: If you boil the funny bone, you get a laughing stock. That's humerus!
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What should be terrifying is that in one action SCOTUS obliterated specific rights of 50.52% of the US population. TODAY, women have less rights in the eyes of the US than they did Thursday, making them once again feel like and actually be second class citizens. PREPOSTEROUS!!!
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Terrific work by
@EvvieJagoda
during her time in my lab!
"Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells" from
@TDCapellini
and colleagues
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Excited to give a talk on July 1st at Queen Mary University of London to
@frdellaccio
and colleagues in the Centre for Experimental Medicine and Rheumatology ()
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1/3 If an NIH reviewer gives a "2" or worse on a review category (e.g. Significance), they must provide a weakness! From one reviewer, I received 3s to 4s on 5 categories & in only one category did they list a weakness. Unacceptable!
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Big shout out to Human Genetics at
@UUtah
for virtually hosting me today as I gave their first seminar of the year. Such an amazing group of people!!!
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Thanks to Craig Lowe & Duke Program in Genetics and Genomics
@DukeUPGG
for having me visit and present my research to such a wonderful community of scientists! It was a real pleasure! Great to see
@HermanPontzer
,
@jtung5
,
@CharlesNunn3
,
@noahdsimons
,
@AmyAGoldberg
,
@goguevara
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Super excited to give a
@USCStemCell
seminar tomorrow and meet wonderful trainees and colleagues!
On Tuesday 8/24 at 11am, the
@USCStemCell
seminar series will kick off with a talk from Terence Capellini from
@Harvard
about "The regulation of human skeletal morphology and disease."
@TDCapellini
@KECKSchool_USC
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