DeFrate Lab
@defratelab
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Musculoskeletal bioengineering laboratory at Duke University, headed by Dr. Lou DeFrate. 🏥📊📈📚
Durham, NC
Joined June 2017
Ended a jam-packed day at #ORS2025 with talks from @thehopefulscie1 and others to discuss interdisciplinary approaches to solutions for OA👏 I am constantly inspired by Hope, who presented on the metabolome of knee OA patients following 18-mo weight loss interventions #ORSSMC
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Starting #ORS2025 with a phenomenal talk from @SadeWill93 on how #aging and the immune system alter and magnify IVD in both males and females, and more so, how #pain fits into this complex relationship 👏🏼🧬
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We are looking forward to seeing everyone at #ORS2025. Come check out our work! @ORSsociety @OrsMeniscus @DukeOrtho @DukePathDept
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Congratulations to our newest PhD candidate, @allisonrbinsn, on her successful prelim yesterday! Thankful to have such a beautiful day to celebrate today. @DukePathDept @DukeOrtho
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The first paper from PhD student @MaxineOlson27 is out. She developed an algorithm to distribute a ground reaction force into multiple vectors to allow for calculation of midfoot and ankle moments using standard clinical gait lab equipment. https://t.co/B5gzFWz8N9
@MU_MCW_BME
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Congrats @thehopefulscie1 Avery and @ronjune2 on a comprehensive and exciting review!
Excited to share our Year in Review on Molecular #Biomarkers of #Osteoarthritis 🎉 We dive into recently published gene, protein, & metabolite biomarkers across joints & sample types. Big strides made, but there’s still work to do! Early detection awaits! @ronjune2 @OACJournal
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It is great to finally share our systematic review on structural extracellular matrix components in soft tissues in osteoarthritis! Congratulations to my co-authors Iwan Raza and @Sarah_JB_S. https://t.co/pt0CKZGBJu
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Check out our comprehensive transcriptomic comparison of inner and outer zone meniscus tissue to cartilage and passaged meniscus cells to identify meniscus specific genes @SciReports. https://t.co/4puMecbTpj
@DukeOrtho @KaileenFei @DaDchasse @nnakelly2
nature.com
Scientific Reports - Meniscus gene expression profiling of inner and outer zone meniscus tissue compared to cartilage and passaged monolayer meniscus cells
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Check out our latest paper in @FrontBioeng showing that healthy but not osteoarthritic meniscus-derived matrix scaffolds can promote ex vivo meniscus repair. This was a great collaboration with our clinical colleagues @DukeOrtho @FirooziSaman @DaDchasse
frontiersin.org
Meniscus tissue is commonly injured due to sports-related injuries and age-related degeneration and approximately 50% of individuals with a meniscus tear wil...
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Excited to be representing @jboerckel and the future Panebianco Lab™️ at #BMES2024!
Super proud of these amazing scientists from our lab presenting at #BMES2024! Departments with faculty searches coming: don't miss @cpane94's Future Faculty Poster tomorrow! @BMESociety
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Congrats Kelsey Collins, PhD @ucsfmskcenter @UCSFOrthosurg for incredible achievements in osteoarthritis research! Awarded NIH Director’s New Innovator Award w $1.5M in funding, she's pioneering therapies to combat musculoskeletal pain and inflammation. https://t.co/ZvAOTaI6vD
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Congrats to @ORSsociety board member @KelseyHCollins on this outstanding achievement and recognition!
Thrilled and grateful to receive this award. We hope to shift paradigms in the complex role of fat interorgan crosstalk on musculoskeletal pain with aging and obesity. Honored to be counted among the #NIHHighRisk labs & these exceptional folks @ucsfmskcenter
@UCSFOrthosurg
@UCSF
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Thrilled and grateful to receive this award. We hope to shift paradigms in the complex role of fat interorgan crosstalk on musculoskeletal pain with aging and obesity. Honored to be counted among the #NIHHighRisk labs & these exceptional folks @ucsfmskcenter
@UCSFOrthosurg
@UCSF
Early-stage investigators proposed #innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: https://t.co/ujuDoPOLUu
#NIHHighRisk
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Congratulations, Kelsey!!
Thrilled and grateful to receive this award. We hope to shift paradigms in the complex role of fat interorgan crosstalk on musculoskeletal pain with aging and obesity. Honored to be counted among the #NIHHighRisk labs & these exceptional folks @ucsfmskcenter
@UCSFOrthosurg
@UCSF
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‘Jolet always has a great question to ask and helps everyone to really think about their research ideas and plans. She is excellent at teaching people in the lab and is an outstanding citizen of NDORMS.’
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Fantastic work by @ArinOestreich and @NHarasymowicz and team - did you know that what your parents ate before you were born will affect your bone health?
@NHarasymowicz and I are excited to share our latest manuscript showing maternal high-fat high-sugar diet impairs bone quality in two generations of mouse offspring in @JOrthopRes. @Farsh_G @khmoley
https://t.co/sXOn1kNiXE
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I'm incredibly honored to be selected as a Spotlight Speaker for the #ORS2025 Annual Meeting. Can't wait to discuss digital twins and the future of image-based outcomes assessment in orthopaedics!
We are thrilled to introduce the Spotlight Speakers for the #ORS2025 Annual Meeting, taking place Feb 7-11 in Phoenix, AZ. These thought leaders will share their innovative insights, shaping the future of #orthopaedic science. View speakers talk titles: https://t.co/1rSieo5Bds
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Hi @OrsSpineSection members and trainees! Join @SheynLab and myself for a virtual networking event on October 9th at 11am pacific. Register here: https://t.co/pVcpr9lRTG
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