Sven Eyckerman
@SvenEyckerman
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Data from the second human treated with a prime edited medicine: a 56-year-old male with chronic granulotamous disease (CGD) had his bone marrow prime edited to insert the missing GT in NCF1, restoring NADPH oxidase function in neutrophils (DHR positivity) several fold beyond the
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Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology | Science Advances
science.org
Virus-like proteins help our cells respond to environmental stress.
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Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients
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Good explainer of a key report https://t.co/LGbOXYNlXi
New, important insights for neurodegenerative diseases by high-throughput proteomics today #GNPC 1. APOε4 carriers have a distinct pro-inflammatory immune proteomic signature of dysregulation in the brain and blood @NatureMedicine
https://t.co/jTCXD7s85F
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New, important insights for neurodegenerative diseases by high-throughput proteomics today #GNPC 1. APOε4 carriers have a distinct pro-inflammatory immune proteomic signature of dysregulation in the brain and blood @NatureMedicine
https://t.co/jTCXD7s85F
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Why do wounds in the mouth heal without scars? New work in @ScienceTM shows that oral fibroblasts suppress fibrosis through the proteins AXL and GAS6, and finds stimulating AXL recapitulates these benefits in facial skin wounds in mice. https://t.co/2OtKcEGhQg
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BioEmu now published in @ScienceMagazine !! What is BioEmu? Check out this video: https://t.co/PAj96iKvR7
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. https://t.co/WwKjj5B0eb
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A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity | Nature Communications
nature.com
Nature Communications - Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by...
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Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science
science.org
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell...
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Leveraging synthetic biology techniques, researchers have engineered a strain of Salmonella that can stimulate mature tertiary lymphoid structures to augment antitumor immunity and shrink colorectal cancer tumors in mice. Learn more in @ScienceTM: https://t.co/HhaNBtB4Fn
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Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells - @PKU1898
https://t.co/yCTD4DSF2k
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@Emily_Alsentzer @_michellemli @zakkohane @shilpanads @ayushnoori @UDNconnect @HarvardDBMI @harvardmed @KempnerInst @mit_hst 🧬 Bonus features: * “Patients‑like‑me” retrieval: finds cohort analogs quickly * Characterisation of novel/differently presenting cases * Attention maps point to key clinical phenotypes that drove predictions 💡 Why it matters: Accessories to current pipelines, SHEPHERD can
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Super excited about our recent paper describing a high throughput screen for functional variants in the context of APDS. Rare disease ain’t always that rare! Great collaboration with Ben Izar and Dusan Bogunovic! https://t.co/dDk3bttJLS
cell.com
In lieu of traditional genetic variant testing approaches, an approach using scalable variant classification in primary human T cells with a clinically relevant readout can inform rapid diagnosis and...
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Just published @ScienceMagazine Engineering T cells within the body, a big step forward for treating cancer and autoimmune diseases, as demonstrated in animal models https://t.co/FR6bE4Scpj
https://t.co/sUqGhxgLAk
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CD8-targeted lipid nanoparticles carrying anti-CD19 CAR mRNA were developed to generate CAR-T cells directly in vivo, demonstrating effective B cell depletion for potential treatment of B cell malignancies and autoimmune diseases. https://t.co/7wq1PmXQqo
#NBThighlight
science.org
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity...
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Leonard Rome’s lab discovered an odd, abundant component of cells in the 1980s—and he’s still trying to figure out what it does. Learn more in this @NewsfromScience feature: https://t.co/WxgEIwacBa
#ScienceMagArchives
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The approved drug methotrexate can potentiate antitumor immune activity and shows signs of boosting the efficacy of checkpoint blockade immunotherapy in patients with solid tumors, according to a preliminary clinical trial. Learn more in @ScienceTM: https://t.co/FHNzhxuTsA
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OligoSeq: Rapid nanopore-sequencing of single-stranded oligonucleotides https://t.co/yY0q0vANE5
#biorxiv_synbio
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Protein expression is still a bottleneck for synthetic biology. Our review in @TrendsinBiotech maps what’s been engineered, and what’s still missing. Predictable expression is key to scaling bio. Thanks to our collaborators; excited to see this reach a wider audience! 🔗
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