Today in @Nature, in work led by @aditimerch, we report the ability to prompt Evo to generate functional de novo genes. You shall know a gene by the company it keeps! 1/n

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature

🗨️ Just published in @NatureBiotech: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)

Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? https://t.co/BG3DVIM13r

New #flowcytometery protocol drop from Oliver Burton. This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down. https://t.co/0gCf6Yk8hS

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the

.@samhegde2006, @MiriamMerad and colleagues report in @Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy. https://t.co/t3ee2VIRRZ @SinaiImmunol @IcahnMountSinai

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. https://t.co/dDBtAjfdYL

Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.

An honor to co-organize this symposium @shalinhnaik and Charlotte. Explore emerging research with field leaders @KeystoneSymp Myeloid Cells: Functional Heterogeneity with Therapeutic Promise, this February in Keystone! https://t.co/wb26A3kZmd #KSMyeloid26

Identifying malignant cells in single-cell transcriptomics data – from first principles to computational solutions, framed around the hallmarks of cancer. New review from the lab! https://t.co/Y7mRnfDuyo

‘Protein evolution as a complex system’ – A new Comment discusses protein evolution in terms of complex systems theory and machine learning approaches to model the dynamics of protein evolution https://t.co/L62p40MOQh

🌹Meet #ROSIE, our new AI that predicts spatial multi-protein expression straight from routine H&E images. Built on a large co‑staining dataset (>1k samples, 16M+ cells). It enables cell phenotyping & tissue structure insights w/o extra assays.

Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀 See ⬇️ for a primer on the next frontier of genomics https://t.co/kl2KOaKziW

No driver mutations could be identified in 181 tumors. The authors do not know why. Perhaps, it's an algorithmic failure. Perhaps, it reflects non genetic contributions to carcinogenesis. What do you think ?

Brain diseases are tough to treat because of the blood-brain barrier. For decades, it stumped drug delivery. At Roche pRED, we solved this! Our Brainshuttle™ technology safely transports drugs across, opening new doors for CNS therapies. Learn more:

Online Now: A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture https://t.co/KBqdgHoaUG

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine https://t.co/v9zFvWwBR0

Fantastic review of somatic testing in PDAC by @EileenMOReilly . Which are the validated biomarkers? How to test?Where we are today, where we need to be in the future…

Uptake of polar lipids through SR-B1 drives NK cell dysfunction in ovarian cancer and can be targeted to restore NK cell cytotoxicity @SciImmunology https://t.co/ZqtJexEOm7 @_Karen__S_ @lynchielydia