FRSimonetti 🦋
@SimonettiFR
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Asst. Prof. of Medicine. Studying HIV persistence, one clone at a time at Johns Hopkins University.
Baltimore, MD
Joined December 2018
While studying two PWH who could not achieve undetectable #HIV viremia, we ran into a paradox: molecular evolution among. defective proviruses!. A proviral mystery novel led the multitalented detective @HariharanViv. Hot off the press on @biorxivpreprint.
2 people with HIV, perfect adherence to meds. Yet, for years, viral loads stayed detectable. We found something wild: defective viruses that couldn’t replicate on their own…but somehow, they were spreading. A collab w/ the inimitable @SimonettiFR.🧵1/n.
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🚨Beautiful paper!🚨.
Leveraging deep mutational scanning and a DNA repair reporter assay, the @AJHGNew provides a resource to resolve VUSs in MUTYH, a key colorectal cancer risk gene: #ASHG #GeneticsDiscoveries
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RT @biorxiv_immuno: Analyzing the T cell receptor repertoire of 2,804 individuals with inflammatory bowel disease identifies public T cell….
biorxiv.org
Whereas altered immune processes have been identified in individuals with inflammatory bowel disease (IBD), potentially causative antigens remain to be identified. By interrogating the immune...
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RT @doctorveera: Creative use of UK Biobank WGS data: fishing out non-human DNA reads from WGS data to measure latent Epstein-Barr viral in….
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RT @Satpathology: I am a strong believer that depth of data can be just as powerful as scale of data. Deep analysis of small groups of huma….
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RT @LabWaggoner: Autoantibodies against cytokines, growth factors, immunoreceptors, & tumor surface proteins robustly modulate immune check….
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RT @Omnia_Reda_: ✨I am delighted to share my Ph.D. work just out in @CommsBio 📢 We describe a novel #HIV #reporter model with dual fluores….
nature.com
Communications Biology - A novel in vitro latency model (HIV-Tocky) suggests the multi-layered nature of HIV-1 post-integration latency at which latent proviruses with a history of expression...
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RT @LabWaggoner: Memory CD8+ T cells have differential cytotoxic capacities across human tissues @SciImmunology @marcus_buggert. https://t.c….
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RT @LabWaggoner: Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @NatImmunol .ht….
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RT @biorxiv_immuno: Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker a….
biorxiv.org
Activation-induced marker (AIM) assays are a promising tool to track antigen-specific T cells, but methodological heterogeneity between research groups hinders their clinical utility. To evaluate AIM...
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RT @yizhoudonglab: RNA chemistry and therapeutics, an exciting and impactful review article in collaboration with Dr. Drew Weissman! @Weiss….
nature.com
Nature Reviews Drug Discovery - Chemical modification represents an effective strategy to improve the stability, efficiency and specificity of RNA therapeutics, while reducing their immunogenicity....
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Congrats @PalPal789 and @LShanlab!.
Humanized mouse models enable the use of reverse genetics to study immune gene functions in human disease @ScienceAdvances @LShanlab.
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RT @aemonten: "Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, funct….
biorxiv.org
Histone H3 Lysine 4 trimethylation (H3K4me3) is widely recognized as a hallmark of actively transcribed gene promoters, yet its precise role in transcriptional regulation remains unresolved[1][1]–[...
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RT @whosainastro: 1/.Why is Ki-67 called Ki-67? And why am I attaching a photo of this beautiful city to the tweet? .If you work in patholo….
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RT @cellhostmicrobe: Immune signatures in subclinical secondary dengue correlating w/protection. New work IDs immune pathways associated w/….
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RT @LabWaggoner: Jurkat T-cell lines widely used in research labs to model TCR or CAR T function are genomically unstable and prone to muta….
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RT @EricTopol: How fast is your brain aging?.A new clock from a single MRI, validated in multiple datasets, linked with risk of dementia, c….
nature.com
Nature Aging - Differences in the Pace of Aging are important for many health outcomes but difficult to measure. Here the authors describe the Dunedin Pace of Aging Calculated from NeuroImaging...
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