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Liang Shan

@LShanlab

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The Shan lab @WUSTLmed studies immune response to #HIV infection

St. Louis, MO USA
Joined September 2020
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@LShanlab
Liang Shan
1 day
RT @LabWaggoner: Humanized mouse models enable the use of reverse genetics to study immune gene functions in human disease @ScienceAdvances….
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@LShanlab
Liang Shan
10 months
RT @v_hornung: 📢 postdoc opportunity!.We’re a team of innate immunity enthusiasts working at the exciting interface of immunology & biochem….
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@LShanlab
Liang Shan
11 months
RT @WashUGenetics: 📢The Department of Genetics is recruiting investigators at all academic levels. Individuals with research programs in an….
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@LShanlab
Liang Shan
1 year
I am proud to introduce the Midwest Developmental Center for AIDS Research. Exciting times for St. Louis and the Midwest region! For more information about our center @MidwestDCFAR, please visit
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@LShanlab
Liang Shan
1 year
Please RT: our lab @WUSTL @WUSTLmed are recruiting two postdoctoral fellows @WUSTLPostdoc to study immune response to #HIV and other #retroviruses. We focus on #HIVcure, viral reservoirs, and #inflammation. For more information, please visit
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@LShanlab
Liang Shan
1 year
RT @sding88: The Ding Lab at the Washington University in St. Louis ( is hiring! We are looking for motivated postd….
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@LShanlab
Liang Shan
1 year
RT @SaligramaLab: #Apply through this job posting "JR81926 Research Technician I – Neurology" #job #researchtech.
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@LShanlab
Liang Shan
1 year
RT @SaligramaLab: We are looking for a #research #technician This is a good fit for #undergraduates looking for #research #experience befo….
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@LShanlab
Liang Shan
1 year
RT @raelwyne: Are you an early- to mid-career HIV investigator or clinical scientist affiliated with or working with an institution or uni….
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@LShanlab
Liang Shan
1 year
RT @NatRevImmunol: CARD8 kills CD4+ T cells in response to HIV entry
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@LShanlab
Liang Shan
1 year
@CellCellPress According to this paradigm, the progressive CD4+ T cell depletion that characterizes pathogenic infections and predominantly involves cells that are not experiencing productive viral infection is due to CARD8 inflammasome activation, which follows virus entry into CD4+ T cells.
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@LShanlab
Liang Shan
1 year
@CellCellPress In conclusion, the current study defines a paradigm to explain the marked differences observed in the clinical outcomes of primate lentiviral infections between pathogenic hosts versus non-pathogenic natural hosts.
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@LShanlab
Liang Shan
1 year
@CellCellPress Next, we showed that HIV protease encapsulated in viral particles is detected by CARD8 during viral entry, which leads to rapid CD4+ T-cell death. In contrast, CD4+T cells from the ‘‘natural’’ hosts are resistant to cell death when exposed to SIV particles.
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@LShanlab
Liang Shan
1 year
@CellCellPress Previously we reported that the CARD8 inflammasome detects HIV protease activity. Here, we found that CARD8 is present in most vertebrates and is functionally conserved in most primates. Interestingly, the ‘‘natural’’ hosts of SIV have acquired loss-of-function mutations in CARD8.
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@LShanlab
Liang Shan
1 year
@CellCellPress In contrast, SIV infection of ‘‘natural’’ hosts such as sooty mangabeys and green monkeys does not cause CD4+ T-cell depletion and AIDS despite high-level viremia.
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@LShanlab
Liang Shan
1 year
@CellCellPress While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this depletion remain incompletely understood, with most cell death involving uninfected cells.
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@LShanlab
Liang Shan
1 year
Excited to share our latest work on the CARD8 #inflammasome in #HIV/SIV pathogenesis and disease progression @CellCellPress Our study suggests that CARD8 drives CD4+ T cell depletion during.HIV infection.
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@LShanlab
Liang Shan
1 year
RT @FitzgeraldKate: We are looking for a new Assistant, Associate or Full Professor interested in joining the Division of Innate Immunity @….
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@LShanlab
Liang Shan
1 year
RT @FISchmidtLab: Looking for an exciting #PhD or #postdoc opportunity? Come join our lab to study #NLRP1 #inflammasomes or #gasdermin pore….
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@LShanlab
Liang Shan
1 year
RT @leslievosshall: 18 days left to apply to the amazing #HannaGrayFellows program @HHMINEWS .$1.5M award to bring you from postdoc to earl….
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