Shiekhattar Lab
@ShiekhattarLab
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@SylvesterCancer @Univmiami
Miami, FL
Joined March 2018
Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis https://t.co/aNL1ocWSde
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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For a quick summary, read the Research Briefing here: https://t.co/lbdFqZRUhy
nature.com
Nature Methods - We present MAPIT-seq, a method that uses antibody-directed RNA editing to concurrently profile in situ RNA-binding protein (RBP)–RNA interactions and transcriptome-wide gene...
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Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA https://t.co/6fB20s9EFJ
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Our new paper is out on @MolecularCell !! We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs. https://t.co/Z3377dDfTE
#StemCells #Transcription #DevelopmentalBiology #RNApolII
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🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab. In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis.
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We also uncover a key role for INTS11 in neurodevelopmental gene regulation.
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We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells. https://t.co/z56RvcTwBT
#RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell
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Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks https://t.co/fD5hcqr65d
#biorxiv_molbio
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Explore emerging #CancerEpigenetics #CancerTherapy #Epigenomics research with field leaders @KeystoneSymp Epigenetic Mechanisms and Cancer Treatment, this February in Santa Fe! https://t.co/4vG8ri9oCb
#KSCancerEpi24
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Hello, check our new paper in BioRxiv. It describes new integrator module (INTS9/INTS11 and BRAT1) regulating the neurodevelopment program.
BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes https://t.co/kkCIk3blz7
#bioRxiv
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Join us for a FUSION Conference on "Genome Regulation through RNA" next February (11-14) in Cancun! https://t.co/ndUnfkUoS5 The meeting will boast cutting-edge work on #epigenomics, #transcription, #lncRNAs & #smallRNAs biology, #genomeintegrity, #epitranscriptomics and more! (1)
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What can machine learning do for your favorite protein complex? A lot! Especially if paired with proteomics and genomics. In collaboration with @WojtekGalej we characterized the 15th Integrator subunit! Shout out to @offley_sarah and @MorPfl for leading this effort #transcription
A combinatorial approach to uncover an additional Integrator subunit
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Interestingly they show H3K4me3 is required to recruit integrator complex, which is essential for the eviction of paused RNAPII and transcriptional elongation.
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Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity https://t.co/O3n0GI7YG7
#bioRxiv
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Our new paper is out on @ScienceAdvances The Integrator complex regulates microRNA abundance through RISC loading https://t.co/mVrayoU3yv Well done @kirstein_nina and @SaDo47654137 and all collaborators.
science.org
Integrator complex loss resulted in a global miRNA decrease due to defective Integrator-dependent Argonaute protein loading.
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Kicking off day 2 with Polycomb & noncoding RNA in cancer, at the 5th Biennial Miami Cancer and Epigenetics Symposium🧬 #MiamiEpigenetics2022 @SylvesterCancer @AsifaAkhtar1 @GardiniLab @harvardmed @ShiekhattarLab
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#MiamiEpigenetics22 Great opportunities for learning and connecting. Many thanks to the organizers @SylvesterCancer and the world renowned speakers 👏👏 😊😊
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We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
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Thrilled that so many experts came to @SylvesterCancer symposium to discuss their most promising and recent research findings AND brainstorm to establish collaborations and help the trainees advance their science and career!
We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
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Impactful symposium in Miami this weekend! Some of our very own @ShiekhattarLab, @lluismorey, @thecimminolab and @TaylorJ_MD discussing the latest discoveries in cancer and epigenetics research. @SylvesterCancer #MiamiEpigenetics2022
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