Felipe Beckedorff
@FBeckedorff
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Congratulations @thecimminolab @tiff_leesang @john_brabson and others. It was a great pleasure to be part of this work !!!
Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
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New blog post: In Google's new paper, "An AI system to help scientists write expert-level empirical software" an AI supposedly "invents" new methods in bioinformatics and infectious disease modeling & forecasting. https://t.co/EdwKddl8lu 🧬🖥️🧪
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Computational methods for analysing multiscale 3D genome organization https://t.co/POkTeAZIdG
#Review by @zocean636, @LoreBonimba, @muyu_wendy_yang, @NCITomMisteli, @faucla & @jmuiuc @4DNucleome @CMUCompBio @SCSatCMU @UCLA @UCLAQCBio @theNCI
nature.com
Nature Reviews Genetics - In this Review, Zhang et al. discuss how recent advances in computational methods are helping to reveal the multiscale features involved in genome folding within the...
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Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA https://t.co/6fB20s9EFJ
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Our new paper is out on @MolecularCell !! We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs. https://t.co/Z3377dDfTE
#StemCells #Transcription #DevelopmentalBiology #RNApolII
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Online now: TAF1 is required for fetal but not adult hematopoiesis in mice
cell.com
Liu et al. identify distinct effects of TAF1 loss on fetal versus adult hematopoiesis using mouse models. They also show that different mechanisms control the activation of genes involved in hemato...
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🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab. In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis.
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We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells. https://t.co/z56RvcTwBT
#RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell
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We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!
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Congratulations @MonikaGullerova !!! It was a great collaboration !! A new insight for INTS6. https://t.co/kCwqSW96Qh
academic.oup.com
Abstract. DNA double-strand breaks (DSBs) represent a lethal form of DNA damage that can trigger cell death or initiate oncogenesis. The activity of RNA po
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Well. It REALLY happened. The plagiarized paper got published. my paper from 2021 - https://t.co/F3740qBLpH new one from 2024 - https://t.co/bmMXP4efvO We'll look at figures in the 🧵 below.
pubmed.ncbi.nlm.nih.gov
Single-cell proteomics is currently far less productive than other approaches. Still, the proteomic community is having trouble adapting to the limitation of having to examine fewer cells than they...
Well, it happened. I am reviewing a paper that is 100% plagiarized from my work. 🔥🔥 not 100% like "I'm certain it's plagiarized", but 100% like "every figure is from my public GitHub repo linked in the paper they are copying". Editor friends - how does one review this?
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"Perfection is impossible. In the 1,526 singles matches I played in my career, I won almost 80% of those matches. But what percentage of points did I win? 54% In other words, even top ranked tennis players win barely more than half the points they play. When you lose ever
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Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published https://t.co/wdDmHDMDCI
nature.com
Nature Genetics - Systematic assessment of cofactor dependencies of nine transcription factors (TFs) and promoters finds that TFs use unique cofactor combinations to modulate distinct steps in...
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We’re excited to announce philanthropist Ken Griffin’s transformative $50M gift to @univmiami. This trajectory-changing donation will fuel groundbreaking #CancerResearch at Sylvester Comprehensive Cancer Center, the only National Cancer Institute (NCI) – designated #cancer center
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Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here:
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Online Now: Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing https://t.co/xibRdVpYRd
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PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo.
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Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks https://t.co/fD5hcqr65d
#biorxiv_molbio
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Non-coding RNAs in disease: from mechanisms to therapeutics
nature.com
Nature Reviews Genetics - In this Review, the authors describe our current knowledge of the role of microRNAs, long non-coding RNAs and circular RNAs in disease, with a focus on cardiovascular,...
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