Matthew Lee
@Science_Matt
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postdoc @IARCWHO, previously @mrcieu, epidemiology, running, he/him
Lyon, France
Joined January 2010
Come join us (virtually) next month for Gen Epi training!
Looking for a course to develop a grounding in a wide range of cutting-edge genetic epidemiological methods for complex traits? Spaces available on our online Genetic Epidemiology online course 11 - 17 Dec. https://t.co/d0J03qoVxV
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Really enjoying this double conference IGES and ASHG trip so far! Come to poster 8006 at 2.30 to hear about how where we carry fat tissue influences our risk of cancer! #ASHG2024
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✨#PhD opportunity with myself, @janemasoli and @jack_bowdenjack We will use #genetics to study how #cardiovascular risk factors vary with age, to improve mechanistic understand and clinical risk prediction🧬📈 Funded for 3.5 years! Deadline 3rd December @UniofExeter
#ASHG24
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We are re-advertising for an exciting 3-yr postdoc post at @imperialcollege using molecular #epidemiology to understand adiposity-driven pancreatic #cancer. Competitive salary and hybrid working options. Deadline 4/11. Email if interested! Pls retweet🙏 https://t.co/a9lkof1DX3
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Interested in combining genetic epidemiology with other methods to identify modifiable causes of disease? If so a research fellow post with @mrc_ieu with @explodecomputer and me now available
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If you have access to myeloma samples/data get in touch - we’d like to expand these analyses! #EpiTwitter
Check out our latest work exploring the role of circulating proteins in multiple myeloma risk using Mendelian randomization https://t.co/RLNFmtMg0q Huge thanks to @Science_Matt @EpiHazelwood @KateBurley6 @ProfSarahJLewis and Sally Moore. @mrc_ieu @BristolCancer @Myeloma_Society
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We have an exciting 3-yr postdoc position at @imperialcollege using molecular #epidemiology to understand adiposity-driven pancreatic #cancer. Possibility of hybrid working. Deadline 24/07 @Mattias31 @r_martin_ @Karl_SmithByrne @EmmaEVincent Pls retweet🙏 https://t.co/GXUhF1j6Rm
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1/4 Excited to share our latest preprint where we used observational and Mendelian randomization methods to explore the role of metabolites as intermediates between adiposity and endometrial cancer using data from UK Biobank (@uk_biobank).
medrxiv.org
Introduction Increased and excess adiposity is associated with increased risk of endometrial cancer (EC) and both of these are associated with circulating metabolite profiles. However, how metaboli...
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We are seeking a mol/genetic epidemiologist or bioinformatician to work at @mrc_ieu in Bristol, UK. Please get in touch if you are interested! #datascience #Bioinformatics
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Really pleased to see our paper published in @eBioMedicine this week. We found that weight loss in people recently diagnosed with type 2 diabetes altered levels of cancer-related proteins in blood🩸. https://t.co/HBXwcHq1AY
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Overpublishing puts enormous stress on students and PIs. And brings tons of money to publishers in STEM. A new study shows that the number of papers is increasing FASTER than the number of #PhD graduates. It’s an amazing work with very useful statistics. Huge kudos to the
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Big new article from me in @PLOSBiology on the past, present and future of science publishing. 6n 🧵 on what I try to do here. (RTs appreciated). 1/n https://t.co/QSVrHMWZEz
journals.plos.org
Academic journals have been publishing the results of biomedical research for more than 350 years. Reviewing their history reveals that the ways in which journals vet submissions have changed over...
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Do you consider doing a PhD in statistical human genetics in a wonderful location? My lab [ https://t.co/F4hvsX9ygI] has open position(s) to explore human interactions, region-specific effects, evolutionary optimal transcript levels by developing advanced causal inference methods
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We have a new short preprint up examining two commonly used non-linear Mendelian randomisation approaches using negative controls in the wake of recent concerns about their performance
medrxiv.org
Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to generate predicted causal...
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Delighted to see our work on the metabolic features of genetic liability to type 2 diabetes and coronary artery disease published in @eBioMedicine today! @joshuaa_bell @emmylooroll @caroline_bull @ECSanderson @mendel_random @mvholmes
https://t.co/6cSlFrVRhI
thelancet.com
Overall, our results support largely distinct metabolic features of genetic liability to T2D and CAD, illustrating both challenges and opportunities for preventing these commonly co-occurring...
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Our data note describing the inflammation proteomics dataset measured by @OlinkProteomics in 9000 @CO90s participants is now out in @WellcomeOpenRes
https://t.co/EclETdfD9X 1/3
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New pre-print available: "Violation of the constant genetic effect assumption can result in biased estimates for non-linear Mendelian randomization" available at https://t.co/GQ3NC6itwE. An update that no scientist ever wants to give. Thread follows:
medrxiv.org
Non-linear Mendelian randomization is an extension of conventional Mendelian randomization that performs separate instrumental variable analyses in strata of the study population with different...
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How many of you know what Cruella Braverman's Public Order Bill contains? It's frankly unbelievable: legislation you might expect in Russia, Iran or Egypt. Here's a summary from my column today:
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Super excited to say that our new paper is out on medRxiv! We apply and discuss the use of Mendelian randomization to estimate the causal role of the gut microbiome in colorectal cancer. #Mendelianrandomization #colorectal #cancer
medrxiv.org
Aim The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian randomiza...
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