Thanks @TylerSbrt yes, a truly remarkable team! Thanks for your involvement

2. Granted MRI and other reflex tests reduce over-diagnosis (and the Ix related morbidity) but is it going to change the lack of OS gain seen here? and how would another test instead of PSA achieve anything better in terms of OS? or much more in terms of PCM?

This is like before and after, but presented at the same time. Basic question (i) will any model of prostate screening alter OS to justify cost & resources needed (ii) if OS not endpoint, will we swap ⬇️morbidity from metastasis with⬆️tx related side effects for a small ⬇️in PCM

Editorial by Jeffrey Tosoian @UroOncJT, David Penson @urogeek, and @UMichPath Arul Chinnaiyan: A Pragmatic Approach to Prostate Cancer Screening https://t.co/AUz4fo1Ftn #EAU24

In this preliminary report from an ongoing clinical trial, a screening protocol—PSA test, a kallikrein panel risk score & MRI before targeted biopsy—detected 1 high-grade prostate cancer per 196 men and 1 low-grade prostate cancer per 909 men. https://t.co/ndwufNvhov #EAU24

Compared with no invitation for routine PSA testing, a single invitation for a PSA screening test reduced prostate cancer mortality at a median follow-up of 15 years, but the absolute mortality benefit was small. https://t.co/tXiy0u50gg #EAU24

Results from the largest trial to date on #ProstateCancer screening shows it has a small impact on reducing deaths but raises concerns of overdiagnosis.🔬 The @CR_UK CAPTrial @r_martin & @UniofOxford @Cambridge_Uni followed over 400,000 men over 15 yrs➡️ https://t.co/zX9sVaD343

@Freddie_Hamdy & @r_martin_ introduce 15yr f/u to #CAP_Study => now see small difference 0.7% vs 0.8% PCa death p=0.02 Need to screen 1000 men to save 1 life from PCa PCa mortality <1% at 15yrs... (20% all cause) #EAU24 @Uroweb

The median 15 year results from @CRUKresearch funded trial of screening for #prostatecancer with a PSA test are published today in JAMA @BristolUni @BrisHealthSci @r_martin_

🆕project from our diet and physical activity theme! Exploring drug targets to treat + prevent cancer. The team is working on finding new + repurposing existing drugs by first identifying #cancer-linked proteins to target Led by @r_martin_ Project page https://t.co/dTjvMwrZGc

We have an exciting Senior Research Associate post using #genetics to⬆️#cancer early detection @mrc_ieu. Hybrid/remote working options. PhD or MSc w/ gen epi experience req'd. Closes 21 Dec @Prime2 @Karl_SmithByrne. Get in touch if interested! Pls retweet🙏 https://t.co/o1HPnG2XwB

Delighted to announce a new fellowship in #mentalhealth in children and young people. With support from Prudence Trust, @EBIBristol and @Bristolalumni have funded @lauralhull to research ways to support neurodivergent young people who camouflage.

Congrats @lauralhull on your award of a Prudence Trust/Elizabeth Blackwell Institute Fellowship to learn about neurodivergent young people’s mental health. Really looking forward to learning more about your important and novel research @EBIBristol @BrisPopHealth

Fantastic opportunity for 5 new PhD students to join us at Bristol @mrc_ieu @BrisMolGenetic @BrisCancerEpi @r_martin_.Open to Home and International students with various project titles. Closing date: 6th December 2023.

We’re advertising a really interesting post @mrc_ieu analysing protein biomarkers in cancer detection! If you have a background in genetic epi & are interested in risk prediction tools for the clinic, look up: https://t.co/GRXyOIsZkg @CRUKresearch @BrisCancerEpi @Prime2

I love my sisters art @Gio_artist and love when she sends me her work as a present! This one’s another gem, arrived today! Thanks sis!

If you’re a mixed methods health services researcher with interest in cancer prevention this @BristolBRC may be just the post for you! Involves great collaboration with colleagues at Bradford Institute of Health Research. https://t.co/y8HGh6FOKr @BrisCancerEpi @BristolCancer

Antonis Antoniou presenting his ambitious vision for data enabled cancer detection, prevention and diagnosis! Major initiative from @CRUKresearch & really excited to be involved. Lovely setting too. #CD3Workshop23 @BrisCancerEpi @BristolCancer

Amazing MRC funded PhD project to exploit genomic data using big data to understand mechanisms behind the prevention of several cancers by physical activity https://t.co/svnaFCGt16 Led by John Campbell, Bath, collaborating with @BristolCancer @BrisCancerEpi funded @GW4BioMedDTP

Want to work in early cancer detection using machine learning on multi-omic data? Look at link below - great opportunity with the brilliant @PaulYousefi, @carolinerelton, Matt Suderman, funded by @CRUKresearch & embedded in @mrc_ieu @BrisCancerEpi @BristolCancer @BristolUni